Pathways Knowlegdes

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Pathway DOIs Note
superpathway of cholesterol biosynthesis

Accession ID: BioCyc:HUMAN_PWY66-5		 -
cholesterol biosynthesis II (via 24,25-dihydrolanosterol)

Accession ID: BioCyc:HUMAN_PWY66-3		 -
cholesterol biosynthesis II (via 24,25-dihydrolanosterol)

Accession ID: BioCyc:META_PWY66-3
  • 10.1006/bbrc.2001.2008
  • 10.1016/s0021-9258(19)50353-2
  • 10.1016/s0022-2275(20)38566-7
  • 10.1016/s0022-2275(20)41987-x
  • 10.1016/s0022-3565(25)24394-4
  • 10.1021/bi00030a003
  • 10.1042/bj3260609
  • 10.1074/jbc.m600395200
 Megha, Bakht O, London E. Cholesterol precursors stabilize ordinary and ceramide-rich ordered lipid domains (lipid rafts) to different degrees. Implications for the Bloch hypothesis and sterol biosynthesis disorders. J Biol Chem. 2006 Aug 04;281(31):21903–13. doi: 10.1074/jbc.m600395200. PMID: 16735517.; Gaylor JL. Membrane-Bound Enzymes of Cholesterol Synthesis from Lanosterol. Biochemical and Biophysical Research Communications. 2002 Apr;292(5):1139–46. doi: 10.1006/bbrc.2001.2008.; Bae SH, Paik YK. Cholesterol biosynthesis from lanosterol: development of a novel assay method and characterization of rat liver microsomal lanosterol delta 24-reductase. Biochem J. 1997 Sep 01;326 ( Pt 2)():609–16. PMID: 9291139; PMCID: PMC1218712.; Trzaskos JM, Ko SS, Magolda RL, Favata MF, Fischer RT, Stam SH, Johnson PR, Gaylor JL. Substrate-based inhibitors of lanosterol 14 alpha-methyl demethylase: I. Assessment of inhibitor structure-activity relationship and cholesterol biosynthesis inhibition properties. Biochemistry. 1995 Aug 01;34(30):9670–6. doi: 10.1021/bi00030a003. PMID: 7626636.; Buttke TM, Folks TM. Complete replacement of membrane cholesterol with 4,4',14-trimethyl sterols in a human T cell line defective in lanosterol demethylation. Journal of Biological Chemistry. 1992 May;267(13):8819–26. doi: 10.1016/s0021-9258(19)50353-2.; Tuck S, Patel H, Safi E, Robinson C. Lanosterol 14 alpha-demethylase (P45014DM): effects of P45014DM inhibitors on sterol biosynthesis downstream of lanosterol. Journal of Lipid Research. 1991 Jun;32(6):893–902. doi: 10.1016/s0022-2275(20)41987-x.; Miettinen TA. Cholesterol metabolism during ketoconazole treatment in man. Journal of Lipid Research. 1988 Jan;29(1):43–51. doi: 10.1016/s0022-2275(20)38566-7.; Kraemer FB, Spilman SD. Effects of ketoconazole on cholesterol synthesis. The Journal of Pharmacology and Experimental Therapeutics. 1986 Sep;238(3):905–11. doi: 10.1016/s0022-3565(25)24394-4.
superpathway of cholesterol biosynthesis

Accession ID: BioCyc:META_PWY66-5
  • 10.1073/pnas.112202799
 Mo C, Valachovic M, Randall SK, Nickels JT, Bard M. Protein-protein interactions among C-4 demethylation enzymes involved in yeast sterol biosynthesis. Proc Natl Acad Sci U S A. 2002 Jul 23;99(15):9739–44. PMID: 12119386; PMCID: PMC124998.
Metabolism

Accession ID: Reactome:R-BTA-1430728		 -
Metabolism of lipids

Accession ID: Reactome:R-BTA-556833		 -
Cholesterol biosynthesis

Accession ID: Reactome:R-BTA-191273
  • 10.1006/bbrc.2001.2008
  • 10.1007/bf00054556
  • 10.1016/j.cmet.2005.01.001
  • 10.1093/hmg/ddg072
  • 10.1146/annurev.nu.06.070186.001333
 Song BL, Javitt NB, DeBose-Boyd RA. Insig-mediated degradation of HMG CoA reductase stimulated by lanosterol, an intermediate in the synthesis of cholesterol. Cell Metab. 2005 Mar;1(3):179–89. doi: 10.1016/j.cmet.2005.01.001. PMID: 16054061.; Herman GE. Disorders of cholesterol biosynthesis: prototypic metabolic malformation syndromes. Hum Mol Genet. 2003 Apr 01;12 Spec No 1():R75–88. doi: 10.1093/hmg/ddg072. PMID: 12668600.; Gaylor JL. Membrane-Bound Enzymes of Cholesterol Synthesis from Lanosterol. Biochemical and Biophysical Research Communications. 2002 Apr;292(5):1139–46. doi: 10.1006/bbrc.2001.2008.; Russell DW. Cholesterol biosynthesis and metabolism. Cardiovasc Drugs Ther. 1992 Apr;6(2):103–10. doi: 10.1007/bf00054556. PMID: 1390320.; Rudney H, Sexton RC. Regulation of cholesterol biosynthesis. Annu Rev Nutr. 1986;6():245–72. doi: 10.1146/annurev.nu.06.070186.001333. PMID: 3524618.
Metabolism

Accession ID: Reactome:R-CFA-1430728		 -
Metabolism of lipids

Accession ID: Reactome:R-CFA-556833		 -
Cholesterol biosynthesis

Accession ID: Reactome:R-CFA-191273
  • 10.1006/bbrc.2001.2008
  • 10.1007/bf00054556
  • 10.1016/j.cmet.2005.01.001
  • 10.1093/hmg/ddg072
  • 10.1146/annurev.nu.06.070186.001333
 Song BL, Javitt NB, DeBose-Boyd RA. Insig-mediated degradation of HMG CoA reductase stimulated by lanosterol, an intermediate in the synthesis of cholesterol. Cell Metab. 2005 Mar;1(3):179–89. doi: 10.1016/j.cmet.2005.01.001. PMID: 16054061.; Herman GE. Disorders of cholesterol biosynthesis: prototypic metabolic malformation syndromes. Hum Mol Genet. 2003 Apr 01;12 Spec No 1():R75–88. doi: 10.1093/hmg/ddg072. PMID: 12668600.; Gaylor JL. Membrane-Bound Enzymes of Cholesterol Synthesis from Lanosterol. Biochemical and Biophysical Research Communications. 2002 Apr;292(5):1139–46. doi: 10.1006/bbrc.2001.2008.; Russell DW. Cholesterol biosynthesis and metabolism. Cardiovasc Drugs Ther. 1992 Apr;6(2):103–10. doi: 10.1007/bf00054556. PMID: 1390320.; Rudney H, Sexton RC. Regulation of cholesterol biosynthesis. Annu Rev Nutr. 1986;6():245–72. doi: 10.1146/annurev.nu.06.070186.001333. PMID: 3524618.
Zymostenol biosynthesis via lathosterol (Kandutsch-Russell pathway)

Accession ID: Reactome:R-DRE-6807062
  • 10.7554/elife.07999
 Mitsche MA, McDonald JG, Hobbs HH, Cohen JC. Flux analysis of cholesterol biosynthesis in vivo reveals multiple tissue and cell-type specific pathways. Elife. 2015 Jun 26;4():e07999. PMID: 26114596; PMCID: PMC4501332.
Cholesterol biosynthesis

Accession ID: Reactome:R-DDI-191273
  • 10.1006/bbrc.2001.2008
  • 10.1007/bf00054556
  • 10.1016/j.cmet.2005.01.001
  • 10.1093/hmg/ddg072
  • 10.1146/annurev.nu.06.070186.001333
 Song BL, Javitt NB, DeBose-Boyd RA. Insig-mediated degradation of HMG CoA reductase stimulated by lanosterol, an intermediate in the synthesis of cholesterol. Cell Metab. 2005 Mar;1(3):179–89. doi: 10.1016/j.cmet.2005.01.001. PMID: 16054061.; Herman GE. Disorders of cholesterol biosynthesis: prototypic metabolic malformation syndromes. Hum Mol Genet. 2003 Apr 01;12 Spec No 1():R75–88. doi: 10.1093/hmg/ddg072. PMID: 12668600.; Gaylor JL. Membrane-Bound Enzymes of Cholesterol Synthesis from Lanosterol. Biochemical and Biophysical Research Communications. 2002 Apr;292(5):1139–46. doi: 10.1006/bbrc.2001.2008.; Russell DW. Cholesterol biosynthesis and metabolism. Cardiovasc Drugs Ther. 1992 Apr;6(2):103–10. doi: 10.1007/bf00054556. PMID: 1390320.; Rudney H, Sexton RC. Regulation of cholesterol biosynthesis. Annu Rev Nutr. 1986;6():245–72. doi: 10.1146/annurev.nu.06.070186.001333. PMID: 3524618.
Cholesterol biosynthesis

Accession ID: Reactome:R-GGA-191273
  • 10.1006/bbrc.2001.2008
  • 10.1007/bf00054556
  • 10.1016/j.cmet.2005.01.001
  • 10.1093/hmg/ddg072
  • 10.1146/annurev.nu.06.070186.001333
 Song BL, Javitt NB, DeBose-Boyd RA. Insig-mediated degradation of HMG CoA reductase stimulated by lanosterol, an intermediate in the synthesis of cholesterol. Cell Metab. 2005 Mar;1(3):179–89. doi: 10.1016/j.cmet.2005.01.001. PMID: 16054061.; Herman GE. Disorders of cholesterol biosynthesis: prototypic metabolic malformation syndromes. Hum Mol Genet. 2003 Apr 01;12 Spec No 1():R75–88. doi: 10.1093/hmg/ddg072. PMID: 12668600.; Gaylor JL. Membrane-Bound Enzymes of Cholesterol Synthesis from Lanosterol. Biochemical and Biophysical Research Communications. 2002 Apr;292(5):1139–46. doi: 10.1006/bbrc.2001.2008.; Russell DW. Cholesterol biosynthesis and metabolism. Cardiovasc Drugs Ther. 1992 Apr;6(2):103–10. doi: 10.1007/bf00054556. PMID: 1390320.; Rudney H, Sexton RC. Regulation of cholesterol biosynthesis. Annu Rev Nutr. 1986;6():245–72. doi: 10.1146/annurev.nu.06.070186.001333. PMID: 3524618.
Metabolism

Accession ID: Reactome:R-MMU-1430728		 -
Metabolism of lipids

Accession ID: Reactome:R-MMU-556833		 -
Metabolism of steroids

Accession ID: Reactome:R-MMU-8957322
  • 10.1007/bf00054556
  • 10.1146/annurev.biochem.72.121801.161712
  • 10.1152/ajprenal.00336.2004
  • 10.1194/jlr.r800054-jlr200
  • 10.1210/er.2003-0030
 Brown MS, Goldstein JL. Cholesterol feedback: from Schoenheimer's bottle to Scap's MELADL. Journal of Lipid Research. 2009 Apr;50():S15–27. doi: 10.1194/jlr.r800054-jlr200.; Dusso AS, Brown AJ, Slatopolsky E. Vitamin D. American Journal of Physiology-Renal Physiology. 2005 Jul;289(1):F8–F28. doi: 10.1152/ajprenal.00336.2004.; Payne AH, Hales DB. Overview of steroidogenic enzymes in the pathway from cholesterol to active steroid hormones. Endocr Rev. 2004 Dec;25(6):947–70. doi: 10.1210/er.2003-0030. PMID: 15583024.; Russell DW. The enzymes, regulation, and genetics of bile acid synthesis. Annu Rev Biochem. 2003;72():137–74. doi: 10.1146/annurev.biochem.72.121801.161712. PMID: 12543708.; Russell DW. Cholesterol biosynthesis and metabolism. Cardiovasc Drugs Ther. 1992 Apr;6(2):103–10. doi: 10.1007/bf00054556. PMID: 1390320.
Zymostenol biosynthesis via lathosterol (Kandutsch-Russell pathway)

Accession ID: Reactome:R-RNO-6807062
  • 10.7554/elife.07999
 Mitsche MA, McDonald JG, Hobbs HH, Cohen JC. Flux analysis of cholesterol biosynthesis in vivo reveals multiple tissue and cell-type specific pathways. Elife. 2015 Jun 26;4():e07999. PMID: 26114596; PMCID: PMC4501332.
Metabolism of steroids

Accession ID: Reactome:R-SCE-8957322
  • 10.1007/bf00054556
  • 10.1146/annurev.biochem.72.121801.161712
  • 10.1152/ajprenal.00336.2004
  • 10.1194/jlr.r800054-jlr200
  • 10.1210/er.2003-0030
 Brown MS, Goldstein JL. Cholesterol feedback: from Schoenheimer's bottle to Scap's MELADL. Journal of Lipid Research. 2009 Apr;50():S15–27. doi: 10.1194/jlr.r800054-jlr200.; Dusso AS, Brown AJ, Slatopolsky E. Vitamin D. American Journal of Physiology-Renal Physiology. 2005 Jul;289(1):F8–F28. doi: 10.1152/ajprenal.00336.2004.; Payne AH, Hales DB. Overview of steroidogenic enzymes in the pathway from cholesterol to active steroid hormones. Endocr Rev. 2004 Dec;25(6):947–70. doi: 10.1210/er.2003-0030. PMID: 15583024.; Russell DW. The enzymes, regulation, and genetics of bile acid synthesis. Annu Rev Biochem. 2003;72():137–74. doi: 10.1146/annurev.biochem.72.121801.161712. PMID: 12543708.; Russell DW. Cholesterol biosynthesis and metabolism. Cardiovasc Drugs Ther. 1992 Apr;6(2):103–10. doi: 10.1007/bf00054556. PMID: 1390320.
Metabolism

Accession ID: Reactome:R-SPO-1430728		 -
Zymostenol biosynthesis via lathosterol (Kandutsch-Russell pathway)

Accession ID: Reactome:R-SPO-6807062
  • 10.7554/elife.07999
 Mitsche MA, McDonald JG, Hobbs HH, Cohen JC. Flux analysis of cholesterol biosynthesis in vivo reveals multiple tissue and cell-type specific pathways. Elife. 2015 Jun 26;4():e07999. PMID: 26114596; PMCID: PMC4501332.