Pathways Knowlegdes
Necessitatibus eius consequatur ex aliquid fuga eum quidem sint consectetur velit
| Pathway | DOIs | Note |
|---|---|---|
| mevalonate pathway I Accession ID: BioCyc:META_PWY-922 |
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Zhong JJ, Yue CJ. Plant cells: secondary metabolite heterogeneity and its manipulation. Adv Biochem Eng Biotechnol. 2005;100():53–88. doi: 10.1007/b136412. PMID: 16270656.; KUZUYAMA T. Mevalonate and Nonmevalonate Pathways for the Biosynthesis of Isoprene Units. Bioscience, Biotechnology, and Biochemistry. 2002 Jan 01;66(8):1619–27. doi: 10.1271/bbb.66.1619.; Daum G, Lees ND, Bard M, Dickson R. Biochemistry, cell biology and molecular biology of lipids of Saccharomyces cerevisiae. Yeast. 1998 Dec;14(16):1471–510. doi: 10.1002/(sici)1097-0061(199812)14:16<1471::aid-yea353>3.0.co;2-y. PMID: 9885152. |
| cholesterol degradation to androstenedione II (cholesterol dehydrogenase) Accession ID: BioCyc:MTBH37RV_PWY-6946 |
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Griffin JE, Gawronski JD, DeJesus MA, Ioerger TR, Akerley BJ, Sassetti CM. High-Resolution Phenotypic Profiling Defines Genes Essential for Mycobacterial Growth and Cholesterol Catabolism. PLoS Pathog. 2011 Sep 29;7(9):e1002251. doi: 10.1371/journal.ppat.1002251. |
| superpathway of cholesterol biosynthesis Accession ID: BioCyc:THAPS_PWY66-5 |
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| superpathway of cholesterol biosynthesis Accession ID: BioCyc:HUMAN_PWY66-5 |
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| cholesterol biosynthesis I Accession ID: BioCyc:HUMAN_PWY66-341 |
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| superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate) Accession ID: BioCyc:HUMAN_PWY-5910 |
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| cholesterol biosynthesis I Accession ID: BioCyc:META_PWY66-341 |
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Marijanovic Z, Laubner D, Moller G, Gege C, Husen B, Adamski J, Breitling R. Closing the gap: identification of human 3-ketosteroid reductase, the last unknown enzyme of mammalian cholesterol biosynthesis. Mol Endocrinol. 2003 Sep;17(9):1715–25. doi: 10.1210/me.2002-0436. PMID: 12829805.; Herman GE. Disorders of cholesterol biosynthesis: prototypic metabolic malformation syndromes. Hum Mol Genet. 2003 Apr 01;12 Spec No 1():R75–88. doi: 10.1093/hmg/ddg072. PMID: 12668600.; Mo C, Valachovic M, Randall SK, Nickels JT, Bard M. Protein-protein interactions among C-4 demethylation enzymes involved in yeast sterol biosynthesis. Proc Natl Acad Sci U S A. 2002 Jul 23;99(15):9739–44. PMID: 12119386; PMCID: PMC124998.; Blagg BS, Jarstfer MB, Rogers DH, Poulter CD. Recombinant squalene synthase. A mechanism for the rearrangement of presqualene diphosphate to squalene. J Am Chem Soc. 2002 Jul 31;124(30):8846–53. doi: 10.1021/ja020411a. PMID: 12137537.; Gaylor JL. Membrane-Bound Enzymes of Cholesterol Synthesis from Lanosterol. Biochemical and Biophysical Research Communications. 2002 Apr;292(5):1139–46. doi: 10.1006/bbrc.2001.2008.; Waterham HR, Koster J, Romeijn GJ, Hennekam RCM, Vreken P, Andersson HC, FitzPatrick DR, Kelley RI, Wanders RJA. Mutations in the 3ß-Hydroxysterol ?24-Reductase Gene Cause Desmosterolosis, an Autosomal Recessive Disorder of Cholesterol Biosynthesis. The American Journal of Human Genetics. 2001 Oct;69(4):685–94. doi: 10.1086/323473.; Vance DE, Van den Bosch H. Cholesterol in the year 2000. Biochim Biophys Acta. 2000 Dec 15;1529(1-3):1–8. doi: 10.1016/s1388-1981(00)00133-5. PMID: 11111073.; Taton M, Husselstein T, Benveniste P, Rahier A. Role of highly conserved residues in the reaction catalyzed by recombinant Delta7-sterol-C5(6)-desaturase studied by site-directed mutagenesis. Biochemistry. 2000 Feb 01;39(4):701–11. doi: 10.1021/bi991467t. PMID: 10651635.; Knopp RH. Drug treatment of lipid disorders. N Engl J Med. 1999 Aug 12;341(7):498–511. doi: 10.1056/nejm199908123410707. PMID: 10441607.; Bae SH, Paik YK. Cholesterol biosynthesis from lanosterol: development of a novel assay method and characterization of rat liver microsomal lanosterol delta 24-reductase. Biochem J. 1997 Sep 01;326 ( Pt 2)():609–16. PMID: 9291139; PMCID: PMC1218712.; Bloch K. Sterol molecule: structure, biosynthesis, and function. Steroids. 1992 Aug;57(8):378–83. doi: 10.1016/0039-128x(92)90081-j. PMID: 1519268.; Fischer RT, Trzaskos JM, Magolda RL, Ko SS, Brosz CS, Larsen B. Lanosterol 14 alpha-methyl demethylase. Isolation and characterization of the third metabolically generated oxidative demethylation intermediate. Journal of Biological Chemistry. 1991 Apr;266(10):6124–32. doi: 10.1016/s0021-9258(18)38093-1.; Goldstein JL, Brown MS. Regulation of the mevalonate pathway. Nature. 1990 Feb 01;343(6257):425–30. doi: 10.1038/343425a0. PMID: 1967820.; Reinhart MP, Billheimer JT, Faust JR, Gaylor JL. Subcellular localization of the enzymes of cholesterol biosynthesis and metabolism in rat liver. Journal of Biological Chemistry. 1987 Jul;262(20):9649–55. doi: 10.1016/s0021-9258(18)47983-5.; Shafiee A, Trzaskos JM, Paik YK, Gaylor JL. Oxidative demethylation of lanosterol in cholesterol biosynthesis: accumulation of sterol intermediates. Journal of Lipid Research. 1986 Nov;27(1):1–10. doi: 10.1016/s0022-2275(20)38858-1.; Paik YK, Billheimer JT, Magolda RL, Gaylor JL. Microsomal enzymes of cholesterol biosynthesis from lanosterol. Solubilization and purification of steroid 8-isomerase. Journal of Biological Chemistry. 1986 May;261(14):6470–7. doi: 10.1016/s0021-9258(19)84586-6.; Kawata S, Trzaskos JM, Gaylor JL. Affinity chromatography of microsomal enzymes on immobilized detergent-solubilized cytochrome b5. Journal of Biological Chemistry. 1986 Mar;261(8):3790–9. doi: 10.1016/s0021-9258(17)35717-4.; Kawata S, Trzaskos JM, Gaylor JL. Microsomal enzymes of cholesterol biosynthesis from lanosterol. Purification and characterization of delta 7-sterol 5-desaturase of rat liver microsomes. Journal of Biological Chemistry. 1985 Jun;260(11):6609–17. doi: 10.1016/s0021-9258(18)88825-1.; Paik YK, Trzaskos JM, Shafiee A, Gaylor JL. Microsomal enzymes of cholesterol biosynthesis from lanosterol. Characterization, solubilization, and partial purification of NADPH-dependent delta 8,14-steroid 14-reductase. Journal of Biological Chemistry. 1984 Nov;259(21):13413–23. doi: 10.1016/s0021-9258(18)90710-6.; Trzaskos JM, Bowen WD, Shafiee A, Fischer RT, Gaylor JL. Cytochrome P-450-dependent oxidation of lanosterol in cholesterol biosynthesis. Microsomal electron transport and C-32 demethylation. Journal of Biological Chemistry. 1984 Nov;259(21):13402–12. doi: 10.1016/s0021-9258(18)90709-x.; Schroepfer GJ. Sterol biosynthesis. Annu Rev Biochem. 1982;51():555–85. doi: 10.1146/annurev.bi.51.070182.003011. PMID: 6810750.; Billheimer JT, Alcorn M, Gaylor JL. Solubilization and partial purification of a microsomal 3-ketosteroid reductase of cholesterol biosynthesis. Archives of Biochemistry and Biophysics. 1981 Oct;211(1):430–8. doi: 10.1016/0003-9861(81)90474-4.; Fukushima H, Grinstead GF, Gaylor JL. Total enzymic synthesis of cholesterol from lanosterol. Cytochrome b5-dependence of 4-methyl sterol oxidase. Journal of Biological Chemistry. 1981 May;256(10):4822–6. doi: 10.1016/s0021-9258(19)69327-0.; Gaylor JL, Miyake Y, Yamano T. Stoichiometry of 4-methyl sterol oxidase of rat liver microsomes. Journal of Biological Chemistry. 1975 Sep;250(18):7159–67. doi: 10.1016/s0021-9258(19)40923-x.; Bechtold MM, Delwiche CV, Comal K, Gaylor JL. Investigation of the component reactions of oxidative sterol demethylation. Role of an endogenous microsomal source of reducing equivalents. J Biol Chem. 1972 Dec 10;247(23):7650–6. PMID: 4404598.; Rahimtula AD, Gaylor JL. Partial purification of a microsomal sterol 4 -carboxylic acid decarboxylase. J Biol Chem. 1972 Jan 10;247(1):9–15. PMID: 4401584.; Miller WL, Brady DR, Gaylor JL. Investigation of the component reactions of oxidative demethylation of sterols. Metabolism of 4 -hydroxymethyl steroids. J Biol Chem. 1971 Aug 25;246(16):5147–53. PMID: 4398294.; Miller WL, Gaylor JL. Investigation of the component reactions of oxidative sterol demethylation. Oxidation of a 4,4-dimethyl sterol to a 4 beta-methyl-4 alpha-carboxylic acid during cholesterol biosynthesis. J Biol Chem. 1970 Oct 25;245(20):5375–81. PMID: 4394229.; Yamamoto S, Bloch K. Studies on Squalene Epoxidase of Rat Liver. Journal of Biological Chemistry. 1970 Apr;245(7):1670–4. doi: 10.1016/s0021-9258(19)77144-0.; Miller WL, Kalafer ME, Gaylor JL, Delwiche CV. Investigation of the Component Reactions of Oxidative Sterol Demethylation. Study of the Aerobic and Anaerobic Processes*. Biochemistry. 1967 Sep 01;6(9):2673–8. doi: 10.1021/bi00861a005.; Dean PDG, de Montellano PRO, Bloch K, Corey EJ. A Soluble 2,3-Oxidosqualene Sterol Cyclase. Journal of Biological Chemistry. 1967 Jun;242(12):3014–5. doi: 10.1016/s0021-9258(18)99606-7.; Bloch K. The biological synthesis of cholesterol. Science. 1965 Oct 01;150(3692):19–28. doi: 10.1126/science.150.3692.19. PMID: 5319508. |
| cholesterol biosynthesis III (via desmosterol) Accession ID: BioCyc:META_PWY66-4 |
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Megha, Bakht O, London E. Cholesterol precursors stabilize ordinary and ceramide-rich ordered lipid domains (lipid rafts) to different degrees. Implications for the Bloch hypothesis and sterol biosynthesis disorders. J Biol Chem. 2006 Aug 04;281(31):21903–13. doi: 10.1074/jbc.m600395200. PMID: 16735517.; Mo C, Valachovic M, Randall SK, Nickels JT, Bard M. Protein-protein interactions among C-4 demethylation enzymes involved in yeast sterol biosynthesis. Proc Natl Acad Sci U S A. 2002 Jul 23;99(15):9739–44. PMID: 12119386; PMCID: PMC124998.; Waterham HR, Koster J, Romeijn GJ, Hennekam RCM, Vreken P, Andersson HC, FitzPatrick DR, Kelley RI, Wanders RJA. Mutations in the 3ß-Hydroxysterol ?24-Reductase Gene Cause Desmosterolosis, an Autosomal Recessive Disorder of Cholesterol Biosynthesis. The American Journal of Human Genetics. 2001 Oct;69(4):685–94. doi: 10.1086/323473.; Bae SH, Paik YK. Cholesterol biosynthesis from lanosterol: development of a novel assay method and characterization of rat liver microsomal lanosterol delta 24-reductase. Biochem J. 1997 Sep 01;326 ( Pt 2)():609–16. PMID: 9291139; PMCID: PMC1218712. |
| cholesterol degradation to androstenedione II (cholesterol dehydrogenase) Accession ID: BioCyc:META_PWY-6946 |
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Thomas ST, VanderVen BC, Sherman DR, Russell DG, Sampson NS. Pathway profiling in Mycobacterium tuberculosis: elucidation of cholesterol-derived catabolite and enzymes that catalyze its metabolism. J Biol Chem. 2011 Dec 23;286(51):43668–78. PMID: 22045806; PMCID: PMC3243565.; Kreit J, Sampson NS. Cholesterol oxidase: physiological functions. The FEBS Journal. 2009 Nov 16;276(23):6844–56. doi: 10.1111/j.1742-4658.2009.07378.x.; Yang X, Dubnau E, Smith I, Sampson NS. Rv1106c from Mycobacterium tuberculosis Is a 3ß-Hydroxysteroid Dehydrogenase. Biochemistry. 2007 Jul 14;46(31):9058–67. doi: 10.1021/bi700688x. |
| cholesterol biosynthesis III (via desmosterol) Accession ID: BioCyc:THAPS_PWY66-4 |
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| cholesterol degradation to androstenedione II (cholesterol dehydrogenase) Accession ID: BioCyc:THAPS_PWY-6946 |
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| cholesterol biosynthesis II (via 24,25-dihydrolanosterol) Accession ID: BioCyc:THAPS_PWY66-3 |
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| cholesterol biosynthesis II (via 24,25-dihydrolanosterol) Accession ID: BioCyc:HUMAN_PWY66-3 |
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| superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate) Accession ID: BioCyc:META_PWY-5910 |
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Rodríguez-Concepción M, Boronat A. Elucidation of the methylerythritol phosphate pathway for isoprenoid biosynthesis in bacteria and plastids. A metabolic milestone achieved through genomics. Plant Physiol. 2002 Nov;130(3):1079–89. PMID: 12427975; PMCID: PMC1540259.; Okada K, Saito T, Nakagawa T, Kawamukai M, Kamiya Y. Five geranylgeranyl diphosphate synthases expressed in different organs are localized into three subcellular compartments in Arabidopsis. Plant Physiol. 2000 Apr;122(4):1045–56. PMID: 10759500; PMCID: PMC58939. |
| cholesterol biosynthesis II (via 24,25-dihydrolanosterol) Accession ID: BioCyc:META_PWY66-3 |
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Megha, Bakht O, London E. Cholesterol precursors stabilize ordinary and ceramide-rich ordered lipid domains (lipid rafts) to different degrees. Implications for the Bloch hypothesis and sterol biosynthesis disorders. J Biol Chem. 2006 Aug 04;281(31):21903–13. doi: 10.1074/jbc.m600395200. PMID: 16735517.; Gaylor JL. Membrane-Bound Enzymes of Cholesterol Synthesis from Lanosterol. Biochemical and Biophysical Research Communications. 2002 Apr;292(5):1139–46. doi: 10.1006/bbrc.2001.2008.; Bae SH, Paik YK. Cholesterol biosynthesis from lanosterol: development of a novel assay method and characterization of rat liver microsomal lanosterol delta 24-reductase. Biochem J. 1997 Sep 01;326 ( Pt 2)():609–16. PMID: 9291139; PMCID: PMC1218712.; Trzaskos JM, Ko SS, Magolda RL, Favata MF, Fischer RT, Stam SH, Johnson PR, Gaylor JL. Substrate-based inhibitors of lanosterol 14 alpha-methyl demethylase: I. Assessment of inhibitor structure-activity relationship and cholesterol biosynthesis inhibition properties. Biochemistry. 1995 Aug 01;34(30):9670–6. doi: 10.1021/bi00030a003. PMID: 7626636.; Buttke TM, Folks TM. Complete replacement of membrane cholesterol with 4,4',14-trimethyl sterols in a human T cell line defective in lanosterol demethylation. Journal of Biological Chemistry. 1992 May;267(13):8819–26. doi: 10.1016/s0021-9258(19)50353-2.; Tuck S, Patel H, Safi E, Robinson C. Lanosterol 14 alpha-demethylase (P45014DM): effects of P45014DM inhibitors on sterol biosynthesis downstream of lanosterol. Journal of Lipid Research. 1991 Jun;32(6):893–902. doi: 10.1016/s0022-2275(20)41987-x.; Miettinen TA. Cholesterol metabolism during ketoconazole treatment in man. Journal of Lipid Research. 1988 Jan;29(1):43–51. doi: 10.1016/s0022-2275(20)38566-7.; Kraemer FB, Spilman SD. Effects of ketoconazole on cholesterol synthesis. The Journal of Pharmacology and Experimental Therapeutics. 1986 Sep;238(3):905–11. doi: 10.1016/s0022-3565(25)24394-4. |
| plant sterol biosynthesis II Accession ID: BioCyc:ARA_PWY-6663 |
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Arnqvist L, Dutta PC, Jonsson L, Sitbon F. Reduction of cholesterol and glycoalkaloid levels in transgenic potato plants by overexpression of a type 1 sterol methyltransferase cDNA. Plant Physiol. 2003 Apr;131(4):1792–9. PMID: 12692338; PMCID: PMC166935.; Schrick K, Mayer U, Martin G, Bellini C, Kuhnt C, Schmidt J, Jürgens G. Interactions between sterol biosynthesis genes in embryonic development of Arabidopsis. The Plant Journal. 2002 Jul;31(1):61–73. doi: 10.1046/j.1365-313x.2002.01333.x.; Nomura T, Kitasaka Y, Takatsuto S, Reid JB, Fukami M, Yokota T. Brassinosteroid/Sterol Synthesis and Plant Growth as Affected bylka and lkb Mutations of Pea1. 1999 Apr 01;119(4):1517–26. doi: 10.1104/pp.119.4.1517.; Choe S, Noguchi T, Fujioka S, Takatsuto S, Tissier CP, Gregory BD, Ross AS, Tanaka A, Yoshida S, Tax FE, Feldmann KA. The Arabidopsis dwf7/ste1 Mutant Is Defective in the ?7 Sterol C-5 Desaturation Step Leading to Brassinosteroid Biosynthesis. Plant Cell. 1999 Feb;11(2):207–21. doi: 10.1105/tpc.11.2.207. |
| superpathway of cholesterol degradation II (cholesterol dehydrogenase) Accession ID: BioCyc:MTBH37RV_PWY-6947 |
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| cholesterol degradation to androstenedione I (cholesterol oxidase) Accession ID: BioCyc:MTBH37RV_PWY-6945 |
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| superpathway of cholesterol degradation II (cholesterol dehydrogenase) Accession ID: BioCyc:MTBCDC1551_PWY-6947 |
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| cholesterol degradation to androstenedione I (cholesterol oxidase) Accession ID: BioCyc:MTBCDC1551_PWY-6945 |
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