D-galactose degradation I (Leloir pathway)

Frey PA. The Leloir pathway: a mechanistic imperative for three enzymes to change the stereochemical configuration of a single carbon in galactose. The FASEB Journal. 1996 Mar;10(4):461–70. doi: 10.1096/fasebj.10.4.8647345.

Metabolites

alpha-D-Galactose

Formula: C6H12O6 (180.0633852)

CAS ID: 3646-73-9

Beryllium

Formula: Be (9.012183)

CAS ID: 7440-41-7

beta-D-Galactose

Formula: C6H12O6 (180.0633852)

CAS ID: 7296-64-2

Cobalt ion

Formula: Co (58.933198)

CAS ID: 22541-53-3

Copper

Formula: Cu (62.929599)

CAS ID: 7440-50-8

Cu+

Formula: Cu (62.929599)

CAS ID: 17493-86-6

D-Glucose 6-phosphate

Formula: C6H13O9P (260.0297178)

CAS ID: 56-73-5

D-Mannose

Formula: C6H12O6 (180.0633852)

CAS ID: 3458-28-4

Fe2+

Formula: Fe (55.934939)

CAS ID: 15438-31-0

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

Magnesium cation

Formula: Mg (23.98505)

CAS ID: 22537-22-0

Manganese(2+)

Formula: Mn (54.938046)

CAS ID: 7439-96-5

Mercaptoethanol

Formula: C2H6OS (78.0139346)

CAS ID: 60-24-2

Mercury(2+)

Formula: Hg (201.970632)

CAS ID: 14302-87-5

Zinc cation

Formula: Zn (63.929145)

CAS ID: 23713-49-7

NADPH(4-)

Formula: C21H26N7O17P3 (741.0598016)

CAS ID: 53-57-6

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

NAD(1-)

Formula: C21H26N7O14P2 (662.1012936000001)

CAS ID: 53-84-9

UDP(3-)

Formula: C9H11N2O12P2 (400.9787246)

CAS ID: 86527-70-0

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:

dTDP(3-)

Formula: C10H13N2O11P2 (398.9994588)

CAS ID:



Enzyme

EC Number name full name note
2.7.1.6 galactokinase ATP:D-galactose 1-phosphotransferase
2.7.7.12 UDP-glucose-hexose-1-phosphate uridylyltransferase UDP-glucose:alpha-D-galactose-1-phosphate uridylyltransferase
5.1.3.2 UDP-glucose 4-epimerase UDP-glucose 4-epimerase
5.1.3.3 Aldose 1-epimerase Aldose 1-epimerase
5.1.3.5 UDP-arabinose 4-epimerase UDP-L-arabinose 4-epimerase
5.4.2.2 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) alpha-D-glucose 1,6-phosphomutase


Proteins

Protein ID name full name
P09147 galE UDP-glucose 4-epimerase
P09148 galT Galactose-1-phosphate uridylyltransferase
P0A6T3 galK Galactokinase
P0A9C3 galM Aldose 1-epimerase
P21955 galM Aldose 1-epimerase
P21977 galE UDP-glucose 4-epimerase
P36938 pgm Phosphoglucomutase