Acetyl-CoA (BioCAD00000005779)

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Metabolite Card

Formula: C23H38N7O17P3S (809.1258)
SMILES: CC(=O)SCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N

Synonyms [en]

acetyl-CoA; Acetyl Coenzyme A; S-acetyl-coenzyme A; AcCoA; S-acetate Coenzyme A; acetyl-S-Coenzyme A

Reviewed

Last reviewed on 2024-06-28.

Cite this Page

Acetyl-CoA. 数据之源，洞见之始. SMRUCC genomics institute, a synthetic life researcher from China. https://biocad_registry.innovation.ac.cn/s/(-)-arctiin (retrieved 2026-01-03) (CAD Registry RN: BioCAD00000005779). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

Note

The main function of coenzyme A is to carry acyl groups (such as the acetyl group) or thioesters. Acetyl-CoA is an important molecule itself. It is the precursor to HMG CoA, which is a vital component in cholesterol and ketone synthesis. (wikipedia). acetyl CoA participates in the biosynthesis of fatty acids and sterols, in the oxidation of fatty acids and in the metabolism of many amino acids. It also acts as a biological acetylating agent.

Cytoplasm Extracellular Membrane Mitochondria Nucleus Endoplasmic reticulum Golgi apparatus Peroxisome
Entity Information

DBLinks

Other DBLinks
  • CAS Registry Number: 66874-07-5
  • CAS Registry Number: 72-89-9
  • PubChem: 3326
  • PubChem: 444493
  • PubChem: 6302
  • ChEBI: ChEBI:15351
  • HMDB: HMDB0001206
  • HMDB: HMDB01206
  • LipidMaps: LMFA07050281
  • KEGG: C00024
  • NCBI MeSH: Acetyl Coenzyme A
  • Wikipedia: Acetyl-CoA
  • RefMet: RM0073686
  • MoNA: CCMSLIB00000479572
  • MoNA: EMBL_MCF_2_0_HRMS_Library000513
  • MoNA: EMBL_MCF_2_0_HRMS_Library000514
  • MoNA: KNA00205
  • MoNA: KNA00207
  • MoNA: KNA00208
  • MoNA: KNA00604
  • MoNA: KNA00605
  • MoNA: KNA00606
  • MoNA: KNA00607
  • MoNA: MoNA010878
  • MoNA: MoNA010879
  • MoNA: MoNA010880
  • MoNA: MoNA010881
  • MoNA: PS016201
  • MoNA: PS016202
  • MoNA: PS016203
  • MoNA: PS016204
  • MoNA: PS016205
  • MoNA: PS016206
  • MoNA: PS016207
  • MoNA: PS016208
  • MoNA: PS016209
  • MoNA: PS016210
  • Metlin: METLIN_36661
  • Coconut NaturalProduct: CNP0240194.1
  • Coconut NaturalProduct: CNP0240194.2
  • Coconut NaturalProduct: CNP0240194.3
  • Coconut NaturalProduct: CNP0240194.5

Class / Ontology

Metabolic Network
ID EC Number Name
KEGG:R00209 1.2.1.104 pyruvate:NAD+ 2-oxidoreductase (CoA-acetylating);
KEGG:R00210 1.2.1.51 pyruvate:NADP+ 2-oxidoreductase (CoA-acetylating)
KEGG:R00211 1.2.3.6 pyruvate:oxygen 2-oxidoreductase (CoA-acetylating)
KEGG:R00212 2.3.1.54 acetyl-CoA:formate C-acetyltransferase
KEGG:R00227 3.1.2.1 acetyl-CoA hydrolase
KEGG:R00228 1.2.1.10 acetaldehyde:NAD+ oxidoreductase (CoA-acetylating)
KEGG:R00229 6.2.1.13 acetate:CoA ligase (ADP-forming)
KEGG:R00230 2.3.1.8 acetyl-CoA:phosphate acetyltransferase
KEGG:R00233 4.1.1.9 malonyl-CoA carboxy-lyase (acetyl-CoA-forming)
KEGG:R00235 6.2.1.1 acetate:CoA ligase (AMP-forming)
KEGG:R00236 6.2.1.1 acetyl adenylate:CoA acetyltransferase
KEGG:R00237 4.1.3.25 (3S)-citramalyl-CoA pyruvate-lyase (acetyl-CoA-forming)
KEGG:R00238 2.3.1.9 acetyl-CoA:acetyl-CoA C-acetyltransferase
KEGG:R00259 2.3.1.1 acetyl-CoA:L-glutamate N-acetyltransferase
KEGG:R00271 2.3.3.14 acetyl-CoA:2-oxoglutarate C-acetyltransferase (thioester-hydrolysing, carboxymethyl forming)
KEGG:R00351 2.3.3.1 acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
KEGG:R00352 2.3.3.8 acetyl-CoA:oxaloacetate C-acetyltransferase [(pro-S)-carboxymethyl-forming, ADP-phosphorylating]
KEGG:R00353 2.1.3.1 malonyl-CoA:pyruvate carboxytransferase
KEGG:R00354 4.1.3.34 (3S)-citryl-CoA oxaloacetate-lyase (acetyl-CoA-forming)
KEGG:R00371 2.3.1.29 acetyl-CoA:glycine C-acetyltransferase
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Organism Source

Taxonomy Source

  1. Escherichia coli [ncbi taxid: 562]
  2. Gypsophila paniculata [ncbi taxid: 235358]
  3. Mus musculus [ncbi taxid: 10090]
  4. Arabidopsis thaliana [ncbi taxid: 3702]
  5. Escherichia coli [ncbi taxid: 562]
  6. Pseudomonas putida [ncbi taxid: 303]
  7. Streptomyces clavuligerus NP1 [ncbi taxid: ]

Pathway Synthetic

pathway id name
BioCyc:TRYPANO_PWY0-1313 acetate conversion to acetyl-CoA
BioCyc:TRYPANO_PWY0-1312 acetate formation from acetyl-CoA I
BioCyc:TRYPANO_ILEUDEG-PWY isoleucine degradation I
BioCyc:TRYPANO_PWY-5436 threonine degradation IV
BioCyc:TRYPANO_THREONINE-DEG2-PWY threonine degradation II
BioCyc:TRYPANO_PWY-561 superpathway of glyoxylate cycle
BioCyc:TRYPANO_ANARESP1-PWY respiration (anaerobic)
BioCyc:TRYPANO_GLYCOLYSIS-TCA-GLYOX-BYPASS superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass
BioCyc:TRYPANO_PWY-922 mevalonate pathway I
BioCyc:TRYPANO_LCTACACAT-PWY lactate oxidation
BioCyc:TRYPANO_PWY66-161 oxidative ethanol degradation III (microsomal)
BioCyc:TRYPANO_P122-PWY heterolactic fermentation
BioCyc:TRYPANO_TCA TCA cycle
BioCyc:TRYPANO_PEP-LIPA-SYN-PWY peptidoglycan and lipid A precursor biosynthesis
BioCyc:TRYPANO_ARG+POLYAMINE-SYN superpathway of arginine and polyamine biosynthesis
BioCyc:TRYPANO_PWY1G-0 mycothiol biosynthesis
BioCyc:TRYPANO_ACETATEUTIL-PWY superpathway of acetate utilization and formation
BioCyc:TRYPANO_PWY0-321 phenylacetate degradation I (aerobic)
BioCyc:TRYPANO_FAO-PWY fatty acid β-oxidation I
BioCyc:TRYPANO_PWY-1622 formaldehyde assimilation I (serine pathway)
View All Pathways