cis-Aconitate (BioCAD00000008596)

blood breast milk cerebrospinal fluid (csf) saliva sweat urine prostate

Metabolite Card

Formula: C6H6O6 (174.0164)
SMILES: OC(=O)C\C(=C\C(O)=O)C(O)=O

Synonyms [en]

cis-aconitate; cis-Aconitic acid; Aconitate; (Z)-1-Propene-1,2,3-tricarboxylic acid; cis-1-propene-1,2,3-tricarboxylic acid; (1Z)-prop-1-ene-1,2,3-tricarboxylic acid

Reviewed

Last reviewed on 2024-06-28.

Cite this Page

cis-Aconitate. 数据之源，洞见之始. SMRUCC genomics institute, a synthetic life researcher from China. https://biocad_registry.innovation.ac.cn/s/(-)-arctiin (retrieved 2026-01-03) (CAD Registry RN: BioCAD00000008596). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

Note

cis-Aconitic acid is an intermediate in the tricarboxylic acid cycle produced by the dehydration of citric acid. The enzyme aconitase (aconitate hydratase; EC 4.2.1.3) catalyses the stereo-specific isomerization of citrate to isocitrate via cis-aconitate in the tricarboxylic acid cycle.

Cytoplasm
Entity Information

DBLinks

Other DBLinks
  • CAS Registry Number: 209-564-4
  • CAS Registry Number: 4023-65-8
  • CAS Registry Number: 499-12-7
  • CAS Registry Number: 585-84-2
  • PubChem: 3707
  • PubChem: 643757
  • ChEBI: ChEBI:16383
  • ChEBI: ChEBI:32805
  • HMDB: HMDB0000072
  • HMDB: HMDB00072
  • KEGG: C00417
  • BioCyc: CIS-ACONITATE
  • NCBI MeSH: Aconitic Acid
  • Wikipedia: Aconitic_acid
  • Wikipedia: Citric acid cycle
  • RefMet: RM0021619
  • MoNA: CCMSLIB00005720654
  • MoNA: EMBL_MCF_2_0_HRMS_Library000328
  • MoNA: HMDB0000072_c_ms_1411
  • MoNA: HMDB0000072_ms_ms_117
  • MoNA: HMDB0000072_ms_ms_118
  • MoNA: HMDB0000072_ms_ms_119
  • MoNA: KNA00542
  • MoNA: KNA00543
  • MoNA: KNA00544
  • MoNA: KNA00545
  • MoNA: KNA00808
  • MoNA: KNA00809
  • MoNA: KNA00810
  • MoNA: KNA00811
  • MoNA: KO000047
  • MoNA: KO000048
  • MoNA: KO000049
  • MoNA: KO000050
  • MoNA: KO000051
  • MoNA: KZ000084
  • MoNA: MT000021
  • MoNA: OUF00095
  • MoNA: PR010012
  • MoNA: PR100734
  • MoNA: PS004601
  • MoNA: PS004607
  • MoNA: PS004608
  • MoNA: PS065701
  • MoNA: PS065703
  • MoNA: PS065704
  • MoNA: PS065705
  • MoNA: PS065707
  • MoNA: PS065708
  • MoNA: PT206570
  • Coconut NaturalProduct: CNP0184949.0

Class / Ontology

Metabolic Network
ID EC Number Name
KEGG:R01325 4.2.1.3 citrate hydro-lyase (cis-aconitate-forming)
KEGG:R01900 4.2.1.3 isocitrate hydro-lyase (cis-aconitate-forming)
KEGG:R02243 4.1.1.6 cis-aconitate carboxy-lyase
KEGG:R02244 5.3.3.7 trans-aconitate delta2-delta3-isomerase
BioCyc:ACONITATEDEHYDR-RXN CIT<=>CIS-ACONITATE + WATER
BioCyc:ACONITATEHYDR-RXN cis-aconitate hydratase
BioCyc:ACONITATE-DELTA-ISOMERASE-RXN 5.3.3.7 CPD-225<=>CIS-ACONITATE
Rhea:RHEA:10229 citrate => cis-aconitate + H2O
Rhea:RHEA:10230 cis-aconitate + H2O => citrate
Rhea:RHEA:10231 citrate <=> cis-aconitate + H2O
Rhea:RHEA:15254 4.1.1.6 cis-aconitate + H+ => itaconate + CO2
Rhea:RHEA:15255 4.1.1.6 itaconate + CO2 => cis-aconitate + H+
Rhea:RHEA:15256 4.1.1.6 cis-aconitate + H+ <=> itaconate + CO2
Rhea:RHEA:17266 5.3.3.7 trans-aconitate => cis-aconitate
Rhea:RHEA:17267 5.3.3.7 cis-aconitate => trans-aconitate
Rhea:RHEA:17268 5.3.3.7 trans-aconitate <=> cis-aconitate
Rhea:RHEA:22145 cis-aconitate + H2O => D-threo-isocitrate
Rhea:RHEA:22146 D-threo-isocitrate => cis-aconitate + H2O
Rhea:RHEA:22147 cis-aconitate + H2O <=> D-threo-isocitrate
Rhea:RHEA:72476 cis-aconitate(in) + citrate(out) => cis-aconitate(out) + citrate(in)
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Organism Source

Taxonomy Source

  1. Achillea alpina [ncbi taxid: 282718]
  2. Aconitum napellus [ncbi taxid: 112591]
  3. Agaricus xanthodermus [ncbi taxid: 83518]
  4. Arabidopsis thaliana [ncbi taxid: 3702]
  5. Arthraxon hispidus [ncbi taxid: 330157]
  6. Banksia burdettii [ncbi taxid: 199760]
  7. Banksia integrifolia [ncbi taxid: 199772]
  8. Capsicum annuum [ncbi taxid: 4072]
  9. Chaenomeles sinensis [ncbi taxid: ]
  10. Chondromyces robustus [ncbi taxid: 83448]
  11. Citrullus lanatus [ncbi taxid: 3654]
  12. Cryptocarya liebertiana [ncbi taxid: 1237525]
  13. Daphnia magna [ncbi taxid: 35525]
  14. Diplopappus filifolius [ncbi taxid: ]
  15. Equisetum palustre [ncbi taxid: 113538]
  16. Euonymus alatus [ncbi taxid: 4307]
  17. Euphrasia pectinata [ncbi taxid: 290215]
  18. Glaucium leiocarpum [ncbi taxid: 2778768]
  19. Glochidion zeylanicum [ncbi taxid: 271535]
  20. Glycine max [ncbi taxid: 3847]
  21. Hedyotis acutangula [ncbi taxid: 462682]
  22. Homo sapiens [ncbi taxid: 9606]
  23. Laurus nobilis [ncbi taxid: 85223]
  24. Lemnalia nitida [ncbi taxid: ]
  25. Meconopsis punicea [ncbi taxid: 248846]
  26. Narcissus cyclamineus [ncbi taxid: 253461]
  27. Neviusia alabamensis [ncbi taxid: 32235]
  28. Papaver bracteatum [ncbi taxid: 215227]
  29. Parmelia loxodella [ncbi taxid: ]
  30. Podocarpus cupressinus [ncbi taxid: ]
  31. Saccharomyces cerevisiae [ncbi taxid: 4932]
  32. Saccharum officinarum [ncbi taxid: 4547]
  33. Saccharum sinensis [ncbi taxid: ]
  34. Salvia multicaulis [ncbi taxid: 1685714]
  35. Sphaeranthus indicus [ncbi taxid: 1205786]
  36. Tanaecium jaroba [ncbi taxid: 3003609]
  37. Tephrosia platycarpa [ncbi taxid: 323657]
  38. Zea mays [ncbi taxid: 4577]

Pathway Synthetic

pathway id name
BioCyc:CALBI_PWY3B3-100 TCA cycle, aerobic respiration
BioCyc:CALBI_GLYOXYLATE-BYPASS glyoxylate cycle
PathBank:SMP0000802 TCA Cycle
PathBank:SMP0000983 Secondary Metabolites: Glyoxylate Cycle
PathBank:SMP0001018 TCA cycle (ubiquinol-2)
PathBank:SMP0001019 TCA cycle (ubiquinol-3)
PathBank:SMP0001020 TCA cycle (ubiquinol-4)
PathBank:SMP0001021 TCA cycle (ubiquinol-5)
PathBank:SMP0001022 TCA cycle (ubiquinol-6)
PathBank:SMP0001023 TCA cycle (ubiquinol-7)
PathBank:SMP0001024 TCA cycle (ubiquinol-8)
PathBank:SMP0001025 TCA cycle (ubiquinol-9)
PathBank:SMP0001026 TCA cycle (ubiquinol-10)
PathBank:SMP0002035 Glycolate and Glyoxylate Degradation II
PathBank:SMP0002037 TCA cycle (ubiquinol-0)
WikiPathways:WP3604 Biochemical pathways: part I
WikiPathways:WP4661 Amino acid metabolism pathway excerpt: histidine catabolism extension
WikiPathways:WP3622 AtMetExpress overview
WikiPathways:WP999 TCA cycle
WikiPathways:WP78 TCA cycle (aka Krebs or citric acid cycle)
View All Pathways