Cytosolic sulfonation of small molecules

Gamage N, Barnett A, Hempel N, Duggleby RG, Windmill KF, Martin JL, McManus ME. Human sulfotransferases and their role in chemical metabolism. Toxicol Sci. 2006 Mar;90(1):5–22. doi: 10.1093/toxsci/kfj061. PMID: 16322073.; Blanchard RL, Freimuth RR, Buck J, Weinshilboum RM, Coughtrie MW. A proposed nomenclature system for the cytosolic sulfotransferase (SULT) superfamily. Pharmacogenetics. 2004 Mar;14(3):199–211. doi: 10.1097/00008571-200403000-00009. PMID: 15167709.; Strott CA. Sulfonation and molecular action. Endocr Rev. 2002 Oct;23(5):703–32. doi: 10.1210/er.2001-0040. PMID: 12372849.; Glatt H. Sulfotransferases in the bioactivation of xenobiotics. Chem Biol Interact. 2000 Dec 01;129(1-2):141–70. doi: 10.1016/s0009-2797(00)00202-7. PMID: 11154739.; Yamazoe Y, Nagata K, Yoshinari K, Fujita K, Shiraga T, Iwasaki K. Sulfotransferase catalyzing sulfation of heterocyclic amines. Cancer Lett. 1999 Sep 01;143(2):103–7. doi: 10.1016/s0304-3835(99)00136-6. PMID: 10503886.; Weinshilboum RM, Otterness DM, Aksoy IA, Wood TC, Her C, Raftogianis RB. Sulfation and sulfotransferases 1: Sulfotransferase molecular biology: cDNAs and genes. FASEB J. 1997 Jan;11(1):3–14. PMID: 9034160.

Metabolites

4-Nitrophenol

Formula: C6H5NO3 (139.02694200000002)

CAS ID: 100-02-7

Acetaminophen

Formula: C8H9NO2 (151.0633254)

CAS ID: 103-90-2

Aryl sulfate

Formula: C6H6O4S (173.9986796)

CAS ID: 937-34-8

Cholesterol

Formula: C27H46O (386.3548466)

CAS ID: 57-88-5

Dehydroepiandrosterone

Formula: C19H28O2 (288.2089188)

CAS ID: 53-43-0

Dopamine 3-O-sulfate

Formula: C8H11NO5S (233.0357916)

CAS ID: 51317-41-0

Estradiol-17beta

Formula: C18H24O2 (272.17762039999997)

CAS ID: 50-28-2

Estrone

Formula: C18H22O2 (270.1619712)

CAS ID: 53-16-7

Estrone 3-sulfate

Formula: C18H22O5S (350.11878820000004)

CAS ID: 481-97-0

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Lithium

Formula: Li (7.016005)

CAS ID: 7439-93-2

Magnesium cation

Formula: Mg (23.98505)

CAS ID: 22537-22-0

N-Hydroxy-4-aminobiphenyl

Formula: C12H11NO (185.0840596)

CAS ID: 1204-79-1

Phenol

Formula: C6H6O (94.0418626)

CAS ID: 108-95-2

Pregnenolone

Formula: C21H32O2 (316.24021719999996)

CAS ID: 145-13-1

Taurolithocholate sulfate

Formula: C26H45NO8S2 (563.258645)

CAS ID: 15324-65-9

Triiodothyronine sulfate

Formula: C15H12I3NO7S (730.7468772)

CAS ID: 31135-55-4

4-Nitrophenyl sulfate

Formula: C6H5NO6S (218.983759)

CAS ID: 1080-04-2

Paracetamol sulfate

Formula: C8H9NO5S (231.0201424)

CAS ID: 10066-90-7

4-Nitrophenyl butyrate

Formula: C10H11NO4 (209.0688046)

CAS ID: 2635-84-9

butyrate

Formula: C4H7O2 (87.0446022)

CAS ID: 461-55-2



Enzyme

EC Number name full name note
2.3.1.-
2.8.2.1 aryl sulfotransferase 3'-phosphoadenylyl-sulfate:phenol sulfotransferase
2.8.2.2 alcohol sulfotransferase 3'-phosphoadenylyl-sulfate:alcohol sulfotransferase
3.1.3.57 inositol-1,4-bisphosphate 1-phosphatase 1D-myo-inositol-1,4-bisphosphate 1-phosphohydrolase
3.1.3.7 3'(2'),5'-bisphosphate nucleotidase adenosine-3'(2'),5'-bisphosphate 3'(2')-phosphohydrolase


Proteins

Protein ID name full name