Phospholipid metabolism

Dowhan W. Molecular basis for membrane phospholipid diversity: why are there so many lipids? Annu Rev Biochem. 1997;66():199–232. doi: 10.1146/annurev.biochem.66.1.199. PMID: 9242906.

Metabolites

Acetaldehyde

Formula: C2H4O (44.0262134)

CAS ID: 75-07-0

Ammonia

Formula: NH3 (17.0265478)

CAS ID: 7664-41-7

Calcium cation

Formula: Ca (39.962591)

CAS ID: 14127-61-8

CDP-choline

Formula: C14H26N4O11P2 (488.10732659999996)

CAS ID: 987-78-0

Choline

Formula: C5H14NO (104.10753340000001)

CAS ID: 62-49-7

Choline phosphate

Formula: C5H15NO4P (184.07386599999998)

CAS ID: 107-73-3

Ethanolamine phosphate

Formula: C2H8NO4P (141.0190938)

CAS ID: 1071-23-4

Glycerol

Formula: C3H8O3 (92.0473418)

CAS ID: 56-81-5

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Magnesium cation

Formula: Mg (23.98505)

CAS ID: 22537-22-0

Manganese(2+)

Formula: Mn (54.938046)

CAS ID: 7439-96-5

myo-Inositol

Formula: C6H12O6 (180.0633852)

CAS ID: 87-89-8

Zinc cation

Formula: Zn (63.929145)

CAS ID: 23713-49-7

Glycerophosphocholine

Formula: C8H20NO6P (257.102819)

CAS ID: 28319-77-9

sn-glycero-3-Phosphoethanolamine

Formula: C5H14NO6P (215.0558714)

CAS ID: 59734-15-5

1-tetradecanoyl-sn-glycero-3-phosphate

Formula: C17H35O7P (382.21202900000003)

CAS ID: 65446-07-3

Glycerol 1-myristate

Formula: C17H34O4 (302.2456964)

CAS ID: 27214-38-6

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

NADH(2-)

Formula: C21H27N7O14P2 (663.1091182000001)

CAS ID:

NAD(1-)

Formula: C21H26N7O14P2 (662.1012936000001)

CAS ID: 53-84-9

sn-glycerol 3-phosphate(2-)

Formula: C3H7O6P (169.9980252)

CAS ID:

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:



Enzyme

EC Number name full name note
2.3.-.-
1.1.5.3 glycerol-3-phosphate dehydrogenase sn-glycerol 3-phosphate:quinone oxidoreductase
2.1.1.71 phosphatidyl-N-methylethanolamine N-methyltransferase S-adenosyl-L-methionine:phosphatidyl-N-methylethanolamine N-methyltransferase
2.3.1.20 diacylglycerol O-acyltransferase acyl-CoA:1,2-diacyl-sn-glycerol O-acyltransferase
2.3.1.23 1-acylglycerophosphocholine O-acyltransferase acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
2.3.1.51 1-acylglycerol-3-phosphate O-acyltransferase acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase
2.7.1.137 phosphatidylinositol 3-kinase ATP:1-phosphatidyl-1D-myo-inositol 3-phosphotransferase
2.7.1.32 choline kinase ATP:choline phosphotransferase
2.7.1.67 1-phosphatidylinositol 4-kinase ATP:1-phosphatidyl-1D-myo-inositol 4-phosphotransferase
2.7.1.68 1-phosphatidylinositol-4-phosphate 5-kinase ATP:1-phosphatidyl-1D-myo-inositol-4-phosphate 5-phosphotransferase
2.7.1.91 sphingosine kinase ATP:sphingoid base 1-phosphotransferase
2.7.11.1 non-specific serine/threonine protein kinase ATP:protein phosphotransferase (non-specific)
2.7.7.14 ethanolamine-phosphate cytidylyltransferase CTP:ethanolamine-phosphate cytidylyltransferase
2.7.7.15 choline-phosphate cytidylyltransferase CTP:choline-phosphate cytidylyltransferase
2.7.7.41 phosphatidate cytidylyltransferase CTP:phosphatidate cytidylyltransferase
2.7.8.11 CDP-diacylglycerol-inositol 3-phosphatidyltransferase CDP-diacylglycerol:myo-inositol 3-phosphatidyltransferase
2.7.8.41 cardiolipin synthase (CMP-forming) CDP-diacylglycerol:L-1-phosphatidyl-glycerol diacylglycerolphosphotransferase (CMP-forming)
3.1.1.23 acylglycerol lipase glycerol-ester acylhydrolase
3.1.1.5 lysophospholipase 2-lysophosphatidylcholine acylhydrolase
3.1.3.1 alkaline phosphatase phosphate-monoester phosphohydrolase (alkaline optimum)
3.1.3.2 acid phosphatase phosphate-monoester phosphohydrolase (acid optimum)
3.1.3.64 phosphatidylinositol-3-phosphatase 1-phosphatidyl-1D-myo-inositol-3-phosphate 3-phosphohydrolase
3.1.3.67 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase 1-phosphatidyl-1D-myo-inositol-3,4,5-trisphosphate 3-phosphohydrolase
3.1.4.4 phospholipase D phosphatidylcholine phosphatidohydrolase
3.6.5.2 small monomeric GTPase GTP phosphohydrolase (cell-regulating)


Proteins

Protein ID name full name
O13819 YMR1_SCHPO Phosphoinositide 3-phosphatase
O13853 its3 Phosphatidylinositol 4-phosphate 5-kinase its3
O13899 crd1 Cardiolipin synthase (CMP-forming) / mitochondrial hydrolase fusion protein
O14159 lcb4 Sphingoid long chain base kinase 4
O14249 CLD1_SCHPO Probable cardiolipin-specific deacylase 1, mitochondrial
O14306 YE8A_SCHPO Probable inositol polyphosphate 5-phosphatase C9G1.10c
O14400 gut2 Glycerol-3-phosphate dehydrogenase, mitochondrial
O42900 vps15 Serine/threonine-protein kinase vps15
O42916 ale1 Lysophospholipid acyltransferase
O60109 PPB_SCHPO Alkaline phosphatase
O60162 YG23_SCHPO Uncharacterized protein C19F5.03
O74827 cho1 Phosphatidyl-N-methylethanolamine N-methyltransferase
O74850 dga1 Diacylglycerol O-acyltransferase 1
O74975 PCY1_SCHPO Probable choline-phosphate cytidylyltransferase
O94305 mgl1 Putative monoglyceride lipase
O94323 YGK5_SCHPO Uncharacterized pyrophosphatase/phosphodiesterase C725.05c
O94361 YHOE_SCHPO Uncharacterized acyltransferase C428.14
O94526 ptn1 Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase ptn1
P36579 arf1 ADP-ribosylation factor 1
P50520 pik3 Phosphatidylinositol 3-kinase pik3
Q09706 pld1 Phospholipase D1
Q10153 pis1 CDP-diacylglycerol--inositol 3-phosphatidyltransferase
Q10276 KICH_SCHPO Choline kinase
Q10366 pik1 Phosphatidylinositol 4-kinase pik1
Q9P381 CDS1_SCHPO Putative phosphatidate cytidylyltransferase
Q9US34 YFZ7_SCHPO Uncharacterized aminotransferase C1039.07c
Q9USJ4 nte1 Lysophospholipase NTE1
Q9USS6 PPA4_SCHPO Probable acid phosphatase SPBC4.06
Q9UT42 lsb6 Phosphatidylinositol 4-kinase lsb6
Q9UTI6 ECT1_SCHPO Probable ethanolamine-phosphate cytidylyltransferase