Metabolism of amine-derived hormones

Ruddick JP, Evans AK, Nutt DJ, Lightman SL, Rook GA, Lowry CA. Tryptophan metabolism in the central nervous system: medical implications. Expert Rev Mol Med. 2006 Aug 31;8(20):1–27. doi: 10.1017/s1462399406000068. PMID: 16942634.; Flatmark T. Catecholamine biosynthesis and physiological regulation in neuroendocrine cells. Acta Physiol Scand. 2000 Jan;168(1):1–17. doi: 10.1046/j.1365-201x.2000.00596.x. PMID: 10691773.; Köhrle J, Brabant G, Hesch RD. Metabolism of the thyroid hormones. Horm Res. 1987;26(1-4):58–78. doi: 10.1159/000180686. PMID: 3297964.

Metabolites

3-Iodo-L-tyrosine

Formula: C9H10INO3 (306.970542)

CAS ID: 70-78-0

4a-Hydroxytetrahydrobiopterin

Formula: C9H15N5O4 (257.11239900000004)

CAS ID: 1379003-93-6

Calcium cation

Formula: Ca (39.962591)

CAS ID: 14127-61-8

CO2

Formula: CO2 (43.98983)

CAS ID: 124-38-9

Fe2+

Formula: Fe (55.934939)

CAS ID: 15438-31-0

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Hydrogen peroxide

Formula: H2O2 (34.0054792)

CAS ID: 7722-84-1

Hydroiodic acid

Formula: HI (127.9123016)

CAS ID: 10034-85-2

Iodide

Formula: I (126.904477)

CAS ID: 20461-54-5

Iodine

Formula: I2 (253.808954)

CAS ID: 7553-56-2

Melatonin

Formula: C13H16N2O2 (232.1211716)

CAS ID: 73-31-4

N-Acetylserotonin

Formula: C12H14N2O2 (218.1055224)

CAS ID: 1210-83-9

NADP+

Formula: C21H29N7O17P3 (744.0832754)

CAS ID: 53-59-8

NADPH

Formula: C21H30N7O17P3 (745.0911)

CAS ID: 2646-71-1

Oxygen

Formula: O2 (31.98983)

CAS ID: 7782-44-7

PQQ

Formula: C14H6N2O8 (330.0124156)

CAS ID: 72909-34-3

Sodium cation

Formula: Na (22.98977)

CAS ID: 17341-25-2

NADPH(4-)

Formula: C21H26N7O17P3 (741.0598016)

CAS ID: 53-57-6

NADP(3-)

Formula: C21H25N7O17P3 (740.051977)

CAS ID: 53-59-8

dopaminium(1+)

Formula: C8H12NO2 (154.0867992)

CAS ID:

serotonin(1+)

Formula: C10H13N2O (177.1027828)

CAS ID:



Enzyme

EC Number name full name note
1.-.-.-
1.11.1.8 iodide peroxidase iodide:hydrogen-peroxide oxidoreductase
1.14.16.2 tyrosine 3-monooxygenase L-tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)
1.14.17.1 dopamine beta-monooxygenase dopamine,ascorbate:oxygen oxidoreductase (beta-hydroxylating)
1.21.1.1 iodotyrosine deiodinase NADP+:L-tyrosine oxidoreductase (iodinating)
1.21.99.3 thyroxine 5-deiodinase 3,3',5'-triiodo-L-thyronine,iodide:acceptor oxidoreductase (iodinating)
1.21.99.4 thyroxine 5'-deiodinase 3,3',5-triiodo-L-thyronine,iodide:acceptor oxidoreductase (iodinating)
1.6.3.1 NAD(P)H oxidase (H2O2-forming) NAD(P)H:oxygen oxidoreductase (H2O2-forming)
2.1.1.28 phenylethanolamine N-methyltransferase S-adenosyl-L-methionine:phenylethanolamine N-methyltransferase
2.1.1.4 acetylserotonin O-methyltransferase S-adenosyl-L-methionine:N-acetylserotonin O-methyltransferase
2.3.1.87 aralkylamine N-acetyltransferase acetyl-CoA:2-arylethylamine N-acetyltransferase
4.1.1.28 aromatic-L-amino-acid decarboxylase Aromatic-L-amino-acid carboxy-lyase


Proteins

Protein ID name full name