Phase II - Conjugation of compounds

McCarver DG, Hines RN. The Ontogeny of Human Drug-Metabolizing Enzymes: Phase II Conjugation Enzymes and Regulatory Mechanisms. The Journal of Pharmacology and Experimental Therapeutics. 2002 Feb;300(2):361–6. doi: 10.1124/jpet.300.2.361.

Metabolites

3,4-Dihydroxybenzoate

Formula: C7H6O4 (154.0266076)

CAS ID: 99-50-3

3beta-Hydroxypregn-5-en-20-one sulfate

Formula: C21H32O5S (396.1970342)

CAS ID: 1247-64-9

4-Nitrophenol

Formula: C6H5NO3 (139.02694200000002)

CAS ID: 100-02-7

6-Mercaptopurine

Formula: C5H4N4S (152.0156664)

CAS ID: 50-44-2

6-Methylmercaptopurine

Formula: C6H6N4S (166.0313156)

CAS ID: 50-66-8

Acetaminophen

Formula: C8H9NO2 (151.0633254)

CAS ID: 103-90-2

Adenosine

Formula: C10H13N5O4 (267.09674980000005)

CAS ID: 58-61-7

Aromatic acid

Formula: C7H6O2 (122.0367776)

CAS ID: 65-85-0

Aryl sulfate

Formula: C6H6O4S (173.9986796)

CAS ID: 937-34-8

Benzo[a]pyrene-7,8-dione

Formula: C20H10O2 (282.068076)

CAS ID: 65199-11-3

Benzo[a]pyrene-cis-7,8-dihydrodiol

Formula: C20H14O2 (286.0993744)

CAS ID:

Cholest-5-ene-3beta,26-diol

Formula: C27H46O2 (402.34976159999997)

CAS ID: 13095-61-9

Cholesterol

Formula: C27H46O (386.3548466)

CAS ID: 57-88-5

CO2

Formula: CO2 (43.98983)

CAS ID: 124-38-9

Dehydroepiandrosterone

Formula: C19H28O2 (288.2089188)

CAS ID: 53-43-0

Dinitrochlorobenzene

Formula: C6H3ClN2O4 (201.9781348)

CAS ID: 97-00-7

Dopamine 3-O-sulfate

Formula: C8H11NO5S (233.0357916)

CAS ID: 51317-41-0

Estradiol-17beta

Formula: C18H24O2 (272.17762039999997)

CAS ID: 50-28-2

Estradiol-17beta 3-sulfate

Formula: C18H24O5S (352.1344374)

CAS ID: 481-96-9

Estrone

Formula: C18H22O2 (270.1619712)

CAS ID: 53-16-7

Estrone 3-sulfate

Formula: C18H22O5S (350.11878820000004)

CAS ID: 481-97-0

Glutathione

Formula: C10H17N3O6S (307.08380220000004)

CAS ID: 70-18-8

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Hydrochloric acid

Formula: HCl (35.9766776)

CAS ID: 7647-01-0

Magnesium cation

Formula: Mg (23.98505)

CAS ID: 22537-22-0

Manganese(2+)

Formula: Mn (54.938046)

CAS ID: 7439-96-5

Mycophenolic acid O-acyl-glucuronide

Formula: C23H28O12 (496.1580688)

CAS ID: 99043-04-6

N-Hydroxy-2-acetamidofluorene

Formula: C15H13NO2 (239.09462380000002)

CAS ID: 53-95-2

N-Hydroxy-4-aminobiphenyl

Formula: C12H11NO (185.0840596)

CAS ID: 1204-79-1

Phenol

Formula: C6H6O (94.0418626)

CAS ID: 108-95-2

Phenyl acetate

Formula: C8H8O2 (136.0524268)

CAS ID: 122-79-2

Potassium cation

Formula: K (38.963708)

CAS ID: 24203-36-9

Pregnenolone

Formula: C21H32O2 (316.24021719999996)

CAS ID: 145-13-1

S-Formylglutathione

Formula: C11H17N3O7S (335.0787172)

CAS ID: 50409-81-9

Salicyluric acid

Formula: C9H9NO4 (195.0531554)

CAS ID: 487-54-7

Taurolithocholate sulfate

Formula: C26H45NO8S2 (563.258645)

CAS ID: 15324-65-9

Zinc cation

Formula: Zn (63.929145)

CAS ID: 23713-49-7

Triiodothyronine sulfate

Formula: C15H12I3NO7S (730.7468772)

CAS ID: 31135-55-4

4-Nitrophenyl sulfate

Formula: C6H5NO6S (218.983759)

CAS ID: 1080-04-2

Paracetamol sulfate

Formula: C8H9NO5S (231.0201424)

CAS ID: 10066-90-7

3alpha-(Sulfonatooxy)-5beta-cholan-24-oate

Formula: C24H38O6S (454.2388968)

CAS ID:

3,3'-Diiodo-L-thyronine

Formula: C15H13I2NO4 (524.8934078000001)

CAS ID: 70-40-6

Salicylates

Formula: C7H5O3 (137.023868)

CAS ID: 63-36-5

formate

Formula: CHO2 (44.997654600000004)

CAS ID: 71-47-6

26-hydroxycholesterol 3-sulfate

Formula: C27H46O5S (482.3065786)

CAS ID:

lithocholate

Formula: C24H39O3 (375.28990439999995)

CAS ID:

mycophenolate

Formula: C17H19O6 (319.1181574)

CAS ID:

5-oxo-L-prolinate

Formula: C5H6NO3 (128.0347666)

CAS ID:

dimethylarsinate

Formula: C2H6AsO2 (136.9583736)

CAS ID: 15132-04-4

dehydroepiandrosterone sulfate(1-)

Formula: C19H27O5S (367.1579112)

CAS ID: 129509-11-1

benzoyl-CoA(4-)

Formula: C28H36N7O17P3S (867.1101196000001)

CAS ID:

adenosine 5'-monophosphate(2-)

Formula: C10H12N5O7P (345.0474332)

CAS ID:

NADPH(4-)

Formula: C21H26N7O17P3 (741.0598016)

CAS ID: 53-57-6

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

UDP-alpha-D-glucose(2-)

Formula: C15H22N2O17P2 (564.0393702)

CAS ID:

NADH(2-)

Formula: C21H27N7O14P2 (663.1091182000001)

CAS ID:

NAD(1-)

Formula: C21H26N7O14P2 (662.1012936000001)

CAS ID: 53-84-9

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:

NADP(3-)

Formula: C21H25N7O17P3 (740.051977)

CAS ID: 53-59-8

S-(2,4-dinitrophenyl)glutathione(1-)

Formula: C16H18N5O10S (472.0774348)

CAS ID:

dopaminium(1+)

Formula: C8H12NO2 (154.0867992)

CAS ID:

2-acetamidofluorene N-sulfate

Formula: C15H13NO5S (319.0514408)

CAS ID: 16808-85-8

methylarsonate(1-)

Formula: CH4AsO3 (138.9376394)

CAS ID: 51952-66-0



Enzyme

EC Number name full name note
2.5.1.18 glutathione transferase RX:glutathione R-transferase
5.3.99.2 Prostaglandin-D synthase (5Z,13E,15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate D-isomerase


Proteins

Protein ID name full name