Synthesis of substrates in N-glycan biosythesis

Sanyal S, Frank CG, Menon AK. Distinct flippases translocate glycerophospholipids and oligosaccharide diphosphate dolichols across the endoplasmic reticulum. Biochemistry. 2008 Jul 29;47(30):7937–46. PMID: 18597486; PMCID: PMC2646664.

Metabolites

alpha-L-Fucopyranose

Formula: C6H12O5 (164.06847019999998)

CAS ID: 6696-41-9

beta-L-Fucopyranose

Formula: C6H12O5 (164.06847019999998)

CAS ID: 13224-93-6

D-Mannose

Formula: C6H12O6 (180.0633852)

CAS ID: 3458-28-4

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Magnesium cation

Formula: Mg (23.98505)

CAS ID: 22537-22-0

pyruvate

Formula: C3H3O3 (87.00821880000001)

CAS ID: 57-60-3

cholate

Formula: C24H39O5 (407.2797344)

CAS ID: 298-43-1

NADPH(4-)

Formula: C21H26N7O17P3 (741.0598016)

CAS ID: 53-57-6

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

GTP(4-)

Formula: C10H12N5O14P3 (518.9593642)

CAS ID: 86527-72-2

NAD(1-)

Formula: C21H26N7O14P2 (662.1012936000001)

CAS ID: 53-84-9

UDP(3-)

Formula: C9H11N2O12P2 (400.9787246)

CAS ID: 86527-70-0

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:

NADP(3-)

Formula: C21H25N7O17P3 (740.051977)

CAS ID: 53-59-8



Enzyme

EC Number name full name note
1.1.1.441 polyprenol dehydrogenase [NAD(P)H] ditrans,polycis-polyprenol:NAD(P)+ oxidoreductase
1.3.1.22 3-oxo-5alpha-steroid 4-dehydrogenase (NADP+) 3-oxo-5alpha-steroid:NADP+ DELTA4-oxidoreductase
1.3.1.94 polyprenal reductase dolichal:NADP+ 2,3-oxidoreductase
2.5.1.87 ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] (2E,6E)-farnesyl-diphosphate:isopentenyl-diphosphate cistransferase (adding 10–55 isopentenyl units)
2.7.7.13 mannose-1-phosphate guanylyltransferase GTP:alpha-D-mannose-1-phosphate guanylyltransferase
2.7.7.43 N-acylneuraminate cytidylyltransferase CTP:N-acylneuraminate cytidylyltransferase
3.5.1.25 N-acetylglucosamine-6-phosphate deacetylase N-acetyl-D-glucosamine-6-phosphate amidohydrolase
4.1.1.33 diphosphomevalonate decarboxylase ATP:(R)-5-diphosphomevalonate carboxy-lyase (adding ATP; isopentenyl-diphosphate-forming)
4.1.3.3 N-acetylneuraminate lyase aceneuramate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
5.1.3.29 L-fucose mutarotase L-fucose 1-epimerase


Proteins

Protein ID name full name