purine nucleotides degradation II (aerobic)

Stoychev G, Kierdaszuk B, Shugar D. Xanthosine and xanthine. Substrate properties with purine nucleoside phosphorylases, and relevance to other enzyme systems. Eur J Biochem. 2002 Aug;269(16):4048–57. doi: 10.1046/j.1432-1033.2002.03097.x. PMID: 12180982.; Bzowska A, Kulikowska E, Shugar D. Purine nucleoside phosphorylases: properties, functions, and clinical aspects. Pharmacol Ther. 2000 Dec;88(3):349–425. doi: 10.1016/s0163-7258(00)00097-8. PMID: 11337031.; Witte DP, Wiginton DA, Hutton JJ, Aronow BJ. Coordinate developmental regulation of purine catabolic enzyme expression in gastrointestinal and postimplantation reproductive tracts. J Cell Biol. 1991 Oct;115(1):179–90. PMID: 1918135; PMCID: PMC2289931.; Fox IH. Metabolic basis for disorders of purine nucleotide degradation. Metabolism. 1981 Jun;30(6):616–34. doi: 10.1016/0026-0495(81)90142-6. PMID: 6262603.

Metabolites

1,10-Phenanthroline

Formula: C12H8N2 (180.0687448)

CAS ID: 66-71-7

Adenosine

Formula: C10H13N5O4 (267.09674980000005)

CAS ID: 58-61-7

Guanine

Formula: C5H5N5O (151.049408)

CAS ID: 73-40-5

Guanosine

Formula: C10H13N5O5 (283.09166480000005)

CAS ID: 118-00-3

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Hypoxanthine

Formula: C5H4N4O (136.03850939999998)

CAS ID: 68-94-0

Inosine

Formula: C10H12N4O5 (268.08076619999997)

CAS ID: 58-63-9

Magnesium cation

Formula: Mg (23.98505)

CAS ID: 22537-22-0

Manganese(2+)

Formula: Mn (54.938046)

CAS ID: 7439-96-5

Potassium cation

Formula: K (38.963708)

CAS ID: 24203-36-9

Rubidium cation

Formula: Rb (84.9118)

CAS ID: 22537-38-8

Xanthine

Formula: C5H4N4O2 (152.0334244)

CAS ID: 69-89-6

Xanthosine

Formula: C10H12N4O6 (284.07568119999996)

CAS ID: 146-80-5

Zinc cation

Formula: Zn (63.929145)

CAS ID: 23713-49-7

(2R,3S)-3-(6-Amino-9H-purin-9-yl)nonan-2-ol

Formula: C14H23N5O (277.1902508)

CAS ID: 51350-19-7

adenosine 5'-monophosphate(2-)

Formula: C10H12N5O7P (345.0474332)

CAS ID:

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

NADH(2-)

Formula: C21H27N7O14P2 (663.1091182000001)

CAS ID:

NAD(1-)

Formula: C21H26N7O14P2 (662.1012936000001)

CAS ID: 53-84-9

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:

p-hydroxymercuribenzoic acid

Formula: C7H6HgO3 (340.00232459999995)

CAS ID: 1126-48-3



Enzyme

EC Number name full name note
1.1.1.205 IMP dehydrogenase IMP:NAD+ oxidoreductase
1.17.1.4 xanthine dehydrogenase xanthine:NAD+ oxidoreductase
1.17.3.2 xanthine oxidase xanthine:oxygen oxidoreductase
2.4.2.1 purine-nucleoside phosphorylase purine-nucleoside:phosphate ribosyltransferase
2.4.2.2 pyrimidine-nucleoside phosphorylase pyrimidine-nucleoside:phosphate (2'-deoxy)-alpha-D-ribosyltransferase
2.7.1.77 nucleoside phosphotransferase nucleotide:nucleoside 5'-phosphotransferase
3.1.3.1 alkaline phosphatase phosphate-monoester phosphohydrolase (alkaline optimum)
3.1.3.35 thymidylate 5'-phosphatase thymidylate 5'-phosphohydrolase
3.1.3.5 5'-nucleotidase 5'-ribonucleotide phosphohydrolase
3.1.3.89 5'-deoxynucleotidase 2'-deoxyribonucleoside 5'-monophosphate phosphohydrolase
3.1.3.91 7-methylguanosine nucleotidase N7-methyl-GMP phosphohydrolase
3.1.3.99 IMP-specific 5'-nucleotidase inosine 5'-phosphate phosphohydrolase
3.5.4.3 guanine deaminase guanine aminohydrolase
3.5.4.4 adenosine deaminase adenosine aminohydrolase


Proteins

Protein ID name full name
P00634 phoA Alkaline phosphatase
P0ABP8 deoD Purine nucleoside phosphorylase DeoD-type
P0ADG7 guaB Inosine-5'-monophosphate dehydrogenase
P0C037 ppnP Pyrimidine/purine nucleoside phosphorylase
P22333 add Adenosine deaminase
P45563 xapA Purine nucleoside phosphorylase 2
P64636 yrfG GMP/IMP nucleotidase YrfG
P76641 guaD Guanine deaminase
Q46799 xdhA Putative xanthine dehydrogenase molybdenum-binding subunit XdhA
Q46800 xdhB Putative xanthine dehydrogenase FAD-binding subunit XdhB