SARS-CoV-2 Infection
Hartenian E, Nandakumar D, Lari A, Ly M, Tucker JM, Glaunsinger BA. The molecular virology of coronaviruses. Journal of Biological Chemistry. 2020 Sep;295(37):12910–34. doi: 10.1074/jbc.rev120.013930.; Fung TS, Liu DX. Human Coronavirus: Host-Pathogen Interaction. Annu Rev Microbiol. 2019 Sep 08;73():529–57. doi: 10.1146/annurev-micro-020518-115759. PMID: 31226023.; de Wit E, van Doremalen N, Falzarano D, Munster VJ. SARS and MERS: recent insights into emerging coronaviruses. Nature Reviews Microbiology. 2016 Jun 27;14(8):523–34. doi: 10.1038/nrmicro.2016.81.; Masters PS. The molecular biology of coronaviruses. Adv Virus Res. 2006;66():193–292. PMID: 16877062; PMCID: PMC7112330.; Marra MA, Jones SJ, Astell CR, Holt RA, Brooks-Wilson A, Butterfield YS, Khattra J, Asano JK, Barber SA, Chan SY, Cloutier A, Coughlin SM, Freeman D, Girn N, Griffith OL, Leach SR, Mayo M, McDonald H, Montgomery SB, Pandoh PK, Petrescu AS, Robertson AG, Schein JE, Siddiqui A, Smailus DE, Stott JM, Yang GS, Plummer F, Andonov A, Artsob H, Bastien N, Bernard K, Booth TF, Bowness D, Czub M, Drebot M, Fernando L, Flick R, Garbutt M, Gray M, Grolla A, Jones S, Feldmann H, Meyers A, Kabani A, Li Y, Normand S, Stroher U, Tipples GA, Tyler S, Vogrig R, Ward D, Watson B, Brunham RC, Krajden M, Petric M, Skowronski DM, Upton C, Roper RL. The Genome sequence of the SARS-associated coronavirus. Science. 2003 May 30;300(5624):1399–404. doi: 10.1126/science.1085953. PMID: 12730501.
Metabolites
Enzyme
| EC Number | name | full name | note |
|---|---|---|---|
| 2.3.1.- | |||
| 2.1.1.319 | type I protein arginine methyltransferase | S-adenosyl-L-methionine:[protein]-L-arginine N-methyltransferase ([protein]-Nomega,Nomega-dimethyl-L-arginine-forming) | |
| 2.1.1.56 | mRNA (guanine-N7)-methyltransferase | S-adenosyl-L-methionine:mRNA (guanine-N7)-methyltransferase | |
| 2.1.1.57 | methyltransferase cap1 | S-adenosyl-L-methionine:5-(N7-methyl 5-triphosphoguanosine)-(ribonucleotide)-[mRNA] 2-O-methyltransferase | |
| 2.3.1.48 | histone acetyltransferase | acetyl-CoA:[protein]-L-lysine acetyltransferase | |
| 2.3.2.27 | RING-type E3 ubiquitin transferase | [E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine:[acceptor protein] ubiquitin transferase (isopeptide bond-forming; RING-type) | |
| 2.4.1.101 | alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase | UDP-N-acetyl-alpha-D-glucosamine:alpha-D-mannosyl-(1->3)-beta-D-mannosyl-glycoprotein 2-beta-N-acetyl-D-glucosaminyltransferase (configuration-inverting) | |
| 2.4.1.143 | alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase | UDP-N-acetyl-alpha-D-glucosamine:alpha-D-mannosyl-(1->6)-beta-D-mannosyl-glycoprotein 2-beta-N-acetyl-D-glucosaminyltransferase (configuration-inverting) | |
| 2.4.1.155 | alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase | UDP-N-acetyl-alpha-D-glucosamine:N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)-beta-D-mannosyl-glycoprotein 6-beta-N-acetyl-D-glucosaminyltransferase (configuration-inverting) | |
| 2.4.1.41 | polypeptide N-acetylgalactosaminyltransferase | UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyl-transferase | |
| 2.4.1.68 | glycoprotein 6-alpha-L-fucosyltransferase | GDP-beta-L-fucose:glycoprotein (L-fucose to asparagine-linked N-acetylglucosamine of N4-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}asparagine) 6-alpha-L-fucosyltransferase | |
| 2.7.1.137 | phosphatidylinositol 3-kinase | ATP:1-phosphatidyl-1D-myo-inositol 3-phosphotransferase | |
| 2.7.1.28 | triokinase | ATP:D-glyceraldehyde 3-phosphotransferase | |
| 2.7.1.29 | glycerone kinase | ATP:glycerone phosphotransferase | |
| 2.7.10.2 | non-specific protein-tyrosine kinase | ATP:[protein]-L-tyrosine O-phosphotransferase (non-specific) | |
| 2.7.11.1 | non-specific serine/threonine protein kinase | ATP:protein phosphotransferase (non-specific) | |
| 2.7.11.10 | IkappaB kinase | ATP:[IkappaB protein] phosphotransferase | |
| 2.7.11.25 | mitogen-activated protein kinase kinase kinase | ATP:protein phosphotransferase (MAPKKKK-activated) | |
| 2.7.11.26 | tau-protein kinase | ATP:[tau-protein] O-phosphotransferase | |
| 2.7.7.48 | RNA-directed RNA polymerase | nucleoside-triphosphate:RNA nucleotidyltransferase (RNA-directed) | |
| 2.7.7.50 | mRNA guanylyltransferase | GTP:mRNA guanylyltransferase | |
| 3.2.1.106 | mannosyl-oligosaccharide glucosidase | Glc3Man9GlcNAc2-[protein] glucohydrolase (configuration-inverting) | |
| 3.2.1.114 | mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase | (1->3)-(1->6)-mannosyl-oligosaccharide alpha-D-mannohydrolase (configuration-retaining) | |
| 3.4.17.23 | angiotensin-converting enzyme 2 | ||
| 3.4.19.12 | ubiquitinyl hydrolase 1 | ||
| 3.4.21.122 | transmembrane protease serine 2 | ||
| 3.4.21.75 | Furin | ||
| 3.4.22.15 | cathepsin L | ||
| 3.4.22.69 | SARS coronavirus main proteinase | ||
| 3.6.1.15 | nucleoside-triphosphate phosphatase | unspecific diphosphate phosphohydrolase | |
| 3.6.4.12 | DNA helicase | ||
| 3.6.4.13 | RNA helicase | ||
| 3.6.4.6 | vesicle-fusing ATPase | ATP phosphohydrolase (vesicle-fusing) | |
| 3.6.5.2 | small monomeric GTPase | GTP phosphohydrolase (cell-regulating) | |
| 3.6.5.3 | protein-synthesizing GTPase | GTP phosphohydrolase (mRNA-translation-assisting) | |
| 4.2.99.18 | DNA-(apurinic or apyrimidinic site) lyase | DNA-(apurinic or apyrimidinic site) 5'-phosphomonoester-lyase | |
| 4.6.1.15 | FAD-AMP lyase (cyclizing) | FAD AMP-lyase (riboflavin-cyclic-4',5'-phosphate-forming) |
Proteins
| Protein ID | name | full name |
|---|