Pathways Knowlegdes
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| Pathway | DOIs | Note |
|---|---|---|
| octaprenyl diphosphate biosynthesis Accession ID: BioCyc:LEISH_PWY-5783 |
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| polyisoprenoid biosynthesis (E. coli) Accession ID: BioCyc:TRYPANO_POLYISOPRENSYN-PWY |
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| octaprenyl diphosphate biosynthesis Accession ID: BioCyc:TRYPANO_PWY-5783 |
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| farnesol biosynthesis Accession ID: BioCyc:CALBI_PWY3B3-16 |
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Décanis N, Savignac K, Rouabhia M. Farnesol promotes epithelial cell defense against Candida albicans through Toll-like receptor 2 expression, interleukin-6 and human beta-defensin 2 production. Cytokine. 2009 Feb;45(2):132–40. doi: 10.1016/j.cyto.2008.11.011. PMID: 19121950.; Cho T, Aoyama T. [Quorum sensing in fungal pathogenesis]. Nihon Rinsho. 2008 Dec;66(12):2279–83. PMID: 19069092.; Hisajima T, Maruyama N, Tanabe Y, Ishibashi H, Yamada T, Makimura K, Nishiyama Y, Funakoshi K, Oshima H, Abe S. Protective effects of farnesol against oral candidiasis in mice. Microbiol Immunol. 2008 Jul;52(7):327–33. doi: 10.1111/j.1348-0421.2008.00044.x. PMID: 18667031.; Shchepin R, Navarathna DHMLP, Dumitru R, Lippold S, Nickerson KW, Dussault PH. Influence of heterocyclic and oxime-containing farnesol analogs on quorum sensing and pathogenicity in Candida albicans. Bioorganic & Medicinal Chemistry. 2008 Feb;16(4):1842–8. doi: 10.1016/j.bmc.2007.11.011.; Davis-Hanna A, Piispanen AE, Stateva LI, Hogan DA. Farnesol and dodecanol effects on the Candida albicans Ras1-cAMP signalling pathway and the regulation of morphogenesis. Molecular Microbiology. 2007 Dec 07;67(1):47–62. doi: 10.1111/j.1365-2958.2007.06013.x.; Martins M, Henriques M, Azeredo J, Rocha SM, Coimbra MA, Oliveira R. Morphogenesis Control in Candida albicans and Candida dubliniensis through Signaling Molecules Produced by Planktonic and Biofilm Cells. Eukaryot Cell. 2007 Dec;6(12):2429–36. doi: 10.1128/ec.00252-07.; Uppuluri P, Mekala S, Chaffin WL. Farnesol-mediated inhibition of Candida albicans yeast growth and rescue by a diacylglycerol analogue. Yeast. 2007 Aug;24(8):681–93. doi: 10.1002/yea.1501. PMID: 17583896.; Rossignol T, Logue ME, Reynolds K, Grenon M, Lowndes NF, Butler G. Transcriptional Response of Candida parapsilosis following Exposure to Farnesol. Antimicrobial Agents and Chemotherapy. 2007 Apr 30;51(7):2304–12. doi: 10.1128/aac.01438.06.; Henriques M, Martins M, Azeredo J, Oliveira R. Effect of farnesol on Candida dubliniensis morphogenesis. Lett Appl Microbiol. 2007 Feb;44(2):199–205. doi: 10.1111/j.1472-765x.2006.02044.x. PMID: 17257261.; Cho T, Aoyama T, Toyoda M, Nakayama H, Chibana H, Kaminishi H. Transcriptional changes in Candida albicans Genes by both farnesol and high cell density at an early stage of morphogenesis in N-acetyl-D-glucosamine medium. Nihon Ishinkin Gakkai Zasshi. 2007;48(4):159–67. doi: 10.3314/jjmm.48.159. PMID: 17975531.; Wendland J, Hellwig D, Walther A, Sickinger S, Shadkchan Y, Martin R, Bauer J, Osherov N, Tretiakov A, Saluz HP. Use of the Porcine Intestinal Epithelium (PIE)-Assay to analyze early stages of colonization by the human fungal pathogen Candida albicans. J Basic Microbiol. 2006;46(6):513–23. doi: 10.1002/jobm.200610167. PMID: 17139615.; Nobile CJ, Mitchell AP. Genetics and genomics of Candida albicans biofilm formation. Cell Microbiol. 2006 Sep;8(9):1382–91. doi: 10.1111/j.1462-5822.2006.00761.x. PMID: 16848788.; Shea JM, Del Poeta M. Lipid signaling in pathogenic fungi. Curr Opin Microbiol. 2006 Aug;9(4):352–8. doi: 10.1016/j.mib.2006.06.003. PMID: 16798065.; Saidi S, Luitaud C, Rouabhia M. In vitro synergistic effect of farnesol and human gingival cells against Candida albicans. Yeast. 2006 Jul 15;23(9):673–87. doi: 10.1002/yea.1389. PMID: 16845684.; Nickerson KW, Atkin AL, Hornby JM. Quorum sensing in dimorphic fungi: farnesol and beyond. Appl Environ Microbiol. 2006 Jun;72(6):3805–13. PMID: 16751484; PMCID: PMC1489610.; Jensen EC, Hornby JM, Pagliaccetti NE, Wolter CM, Nickerson KW, Atkin AL. Farnesol restores wild-type colony morphology to 96% of Candida albicans colony morphology variants recovered following treatment with mutagens. Genome. 2006 Apr;49(4):346–53. doi: 10.1139/g05-117. PMID: 16699554.; Hogan DA. Talking to themselves: autoregulation and quorum sensing in fungi. Eukaryot Cell. 2006 Apr;5(4):613–9. PMID: 16607008; PMCID: PMC1459667.; Navarathna DH, Hornby JM, Hoerrmann N, Parkhurst AM, Duhamel GE, Nickerson KW. Enhanced pathogenicity of Candida albicans pre-treated with subinhibitory concentrations of fluconazole in a mouse model of disseminated candidiasis. J Antimicrob Chemother. 2005 Dec;56(6):1156–9. doi: 10.1093/jac/dki383. PMID: 16239285.; Braun PC. The effect of farnesol on amino acid incorporation by a wild-type and cell-wall variant strain of Candida albicans. Can J Microbiol. 2005 Aug;51(8):715–8. doi: 10.1139/w05-050. PMID: 16234870.; Mosel DD, Dumitru R, Hornby JM, Atkin AL, Nickerson KW. Farnesol Concentrations Required To Block Germ Tube Formation in Candida albicans in the Presence and Absence of Serum. Appl Environ Microbiol. 2005 Aug;71(8):4938–40. doi: 10.1128/aem.71.8.4938-4940.2005.; Enjalbert B, Whiteway M. Release from Quorum-Sensing Molecules Triggers Hyphal Formation during Candida albicans Resumption of Growth. Eukaryot Cell. 2005 Jul;4(7):1203–10. doi: 10.1128/ec.4.7.1203-1210.2005.; Shchepin R, Dumitru R, Nickerson KW, Lund M, Dussault PH. Biologically active fluorescent farnesol analogs. Chem Biol. 2005 Jun;12(6):639–41. doi: 10.1016/j.chembiol.2005.04.008. PMID: 15975508.; Laffey SF, Butler G. Phenotype switching affects biofilm formation by Candida parapsilosis. Microbiology (Reading). 2005 Apr;151(Pt 4):1073–81. doi: 10.1099/mic.0.27739-0. PMID: 15817776.; Cao Y, Cao Y, Xu Z, Ying K, Li Y, Xie Y, Zhu Z, Chen W, Jiang Y. cDNA Microarray Analysis of Differential Gene Expression in Candida albicans Biofilm Exposed to Farnesol. Antimicrob Agents Chemother. 2005 Feb;49(2):584–9. doi: 10.1128/aac.49.2.584-589.2005.; Kruppa M, Krom BP, Chauhan N, Bambach AV, Cihlar RL, Calderone RA. The Two-Component Signal Transduction Protein Chk1p Regulates Quorum Sensing in Candida albicans. Eukaryot Cell. 2004 Aug;3(4):1062–5. doi: 10.1128/ec.3.4.1062-1065.2004.; Sato T, Watanabe T, Mikami T, Matsumoto T. Farnesol, a Morphogenetic Autoregulatory Substance in the Dimorphic Fungus Candida albicans, Inhibits Hyphae Growth through Suppression of a Mitogen-Activated Protein Kinase Cascade. Biological & Pharmaceutical Bulletin. 2004;27(5):751–2. doi: 10.1248/bpb.27.751.; Shchepin R, Hornby JM, Burger E, Niessen T, Dussault P, Nickerson KW. Quorum sensing in Candida albicans: probing farnesol's mode of action with 40 natural and synthetic farnesol analogs. Chem Biol. 2003 Aug;10(8):743–50. doi: 10.1016/s1074-5521(03)00158-3. PMID: 12954333. |
| epoxysqualene biosynthesis Accession ID: BioCyc:CALBI_PWY-5670 |
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| trans, trans-farnesyl diphosphate biosynthesis Accession ID: BioCyc:CALBI_PWY-5123 |
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| superpathway of ergosterol biosynthesis Accession ID: BioCyc:CALBI_ERGOSTEROL-SYN-PWY |
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Sun LM, Lv BB, Cheng AX, Wu XZ, Lou HX. The Effect of Plagiochin E Alone and in Combination with Fluconazole on the Ergosterol Biosynthesis of Candida albicans. Biological & Pharmaceutical Bulletin. 2009;32(1):36–40. doi: 10.1248/bpb.32.36. |
| trans, trans-farnesyl diphosphate biosynthesis I Accession ID: BioCyc:LEISH_PWY-5123 |
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| di-trans,poly-cis-undecaprenyl phosphate biosynthesis Accession ID: BioCyc:TRYPANO_PWY-5785 |
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| ubiquinone (coenzyme Q) biosynthesis Accession ID: BioCyc:CALBI_PWY3B3-10 |
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| polyisoprenoid biosynthesis (E. coli) Accession ID: BioCyc:LEISH_POLYISOPRENSYN-PWY |
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| superpathway of sterol biosynthesis Accession ID: BioCyc:LEISH_PWY3IU-93 |
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Ginger ML, Chance ML, Sadler IH, Goad LJ. The Biosynthetic Incorporation of the Intact Leucine Skeleton into Sterol by the Trypanosomatid Leishmania mexicana. Journal of Biological Chemistry. 2001 Apr;276(15):11674–82. doi: 10.1074/jbc.m006850200.; Ginger ML, Prescott MC, Reynolds DG, Chance ML, Goad LJ. Utilization of leucine and acetate as carbon sources for sterol and fatty acid biosynthesis by Old and New World Leishmania species, Endotrypanum monterogeii and Trypanosoma cruzi. European Journal of Biochemistry. 2000 May;267(9):2555–66. doi: 10.1046/j.1432-1327.2000.01261.x. |
| di-trans,poly-cis-undecaprenyl phosphate biosynthesis Accession ID: BioCyc:LEISH_PWY-5785 |
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| ergosterol biosynthesis Accession ID: BioCyc:LEISH_PWY3IU-214 |
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Zhou W, Lepesheva GI, Waterman MR, Nes WD. Mechanistic Analysis of a Multiple Product Sterol Methyltransferase Implicated in Ergosterol Biosynthesis in Trypanosoma brucei. Journal of Biological Chemistry. 2006 Mar;281(10):6290–6. doi: 10.1074/jbc.m511749200.; Roberts CW, McLeod R, Rice DW, Ginger M, Chance ML, Goad LJ. Fatty acid and sterol metabolism: potential antimicrobial targets in apicomplexan and trypanosomatid parasitic protozoa. Molecular and Biochemical Parasitology. 2003 Feb;126(2):129–42. doi: 10.1016/s0166-6851(02)00280-3.; Ginger ML, Chance ML, Sadler IH, Goad LJ. The Biosynthetic Incorporation of the Intact Leucine Skeleton into Sterol by the Trypanosomatid Leishmania mexicana. Journal of Biological Chemistry. 2001 Apr;276(15):11674–82. doi: 10.1074/jbc.m006850200.; Ginger ML, Prescott MC, Reynolds DG, Chance ML, Goad LJ. Utilization of leucine and acetate as carbon sources for sterol and fatty acid biosynthesis by Old and New World Leishmania species, Endotrypanum monterogeii and Trypanosoma cruzi. European Journal of Biochemistry. 2000 May;267(9):2555–66. doi: 10.1046/j.1432-1327.2000.01261.x. |
| trans, trans-farnesyl diphosphate biosynthesis I Accession ID: BioCyc:TRYPANO_PWY-5123 |
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| Porphyrin Metabolism Accession ID: PathBank:SMP0000953 |
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| Secondary Metabolites: Methylerythritol Phosphate and Polyisoprenoid Biosynthesis Accession ID: PathBank:SMP0000974 |
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| Secondary Metabolites: Ubiquinol Biosynthesis Accession ID: PathBank:SMP0000997 |
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| Secondary Metabolites: Ubiquinol Biosynthesis 2 Accession ID: PathBank:SMP0002050 |
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| Sterol biosynthesis Accession ID: Plant Reactome:R-HVU-1119370 |
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