ergosterol biosynthesis

Zhou W, Lepesheva GI, Waterman MR, Nes WD. Mechanistic Analysis of a Multiple Product Sterol Methyltransferase Implicated in Ergosterol Biosynthesis in Trypanosoma brucei. Journal of Biological Chemistry. 2006 Mar;281(10):6290–6. doi: 10.1074/jbc.m511749200.; Roberts CW, McLeod R, Rice DW, Ginger M, Chance ML, Goad LJ. Fatty acid and sterol metabolism: potential antimicrobial targets in apicomplexan and trypanosomatid parasitic protozoa. Molecular and Biochemical Parasitology. 2003 Feb;126(2):129–42. doi: 10.1016/s0166-6851(02)00280-3.; Ginger ML, Chance ML, Sadler IH, Goad LJ. The Biosynthetic Incorporation of the Intact Leucine Skeleton into Sterol by the Trypanosomatid Leishmania mexicana. Journal of Biological Chemistry. 2001 Apr;276(15):11674–82. doi: 10.1074/jbc.m006850200.; Ginger ML, Prescott MC, Reynolds DG, Chance ML, Goad LJ. Utilization of leucine and acetate as carbon sources for sterol and fatty acid biosynthesis by Old and New World Leishmania species, Endotrypanum monterogeii and Trypanosoma cruzi. European Journal of Biochemistry. 2000 May;267(9):2555–66. doi: 10.1046/j.1432-1327.2000.01261.x.

Metabolites

(S)-2,3-Epoxysqualene

Formula: C30H50O (426.386145)

CAS ID: 54910-48-4

7-Dehydrodesmosterol

Formula: C27H42O (382.3235482)

CAS ID: 1715-86-2

Ergosterol

Formula: C28H44O (396.3391974)

CAS ID: 57-87-4

Fecosterol

Formula: C28H46O (398.3548466)

CAS ID: 516-86-9

Formate

Formula: CH2O2 (46.0054792)

CAS ID: 64-18-6

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Lanosterol

Formula: C30H50O (426.386145)

CAS ID: 79-63-0

NADP+

Formula: C21H29N7O17P3 (744.0832754)

CAS ID: 53-59-8

NADPH

Formula: C21H30N7O17P3 (745.0911)

CAS ID: 2646-71-1

Oxygen

Formula: O2 (31.98983)

CAS ID: 7782-44-7

S-Adenosyl-L-methionine

Formula: C15H22N6O5S (398.1372322)

CAS ID: 29908-03-0

Squalene

Formula: C30H50 (410.39123)

CAS ID: 111-02-4

Zymosterol

Formula: C27H44O (384.3391974)

CAS ID: 128-33-6



Enzyme

EC Number name full name note


Proteins

Protein ID name full name