Pathways Knowlegdes

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Pathway DOIs Note
Metabolism

Accession ID: Reactome:R-BTA-1430728		 -
Phase I - Functionalization of compounds

Accession ID: Reactome:R-BTA-211945
  • 10.1208/aapsj080112
  • 10.1517/17425255.2.6.895
  • 10.2174/1389200023337054
 Strolin Benedetti M, Whomsley R, Baltes E. Involvement of enzymes other than CYPs in the oxidative metabolism of xenobiotics. Expert Opinion on Drug Metabolism & Toxicology. 2006 Nov 24;2(6):895–921. doi: 10.1517/17425255.2.6.895.; Guengerich FP. Cytochrome P450s and other enzymes in drug metabolism and toxicity. The AAPS Journal. 2006 Mar 01;8(1):e101–11. doi: 10.1208/aapsj080112.; Danielson PB. The cytochrome P450 superfamily: biochemistry, evolution and drug metabolism in humans. Curr Drug Metab. 2002 Dec;3(6):561–97. doi: 10.2174/1389200023337054. PMID: 12369887.
Biological oxidations

Accession ID: Reactome:R-CEL-211859		 -
Metabolism

Accession ID: Reactome:R-CFA-1430728		 -
Biological oxidations

Accession ID: Reactome:R-HSA-211859		 -
FMO oxidises nucleophiles

Accession ID: Reactome:R-HSA-217271
  • 10.1016/j.pharmthera.2005.01.001
 Krueger SK, Williams DE. Mammalian flavin-containing monooxygenases: structure/function, genetic polymorphisms and role in drug metabolism. Pharmacology & Therapeutics. 2005 Jun;106(3):357–87. doi: 10.1016/j.pharmthera.2005.01.001.; Cashman JR. The role of flavin-containing monooxygenases in drug metabolism and development. Curr Opin Drug Discov Devel. 2003 Jul;6(4):486–93. PMID: 12951812.
Metabolism

Accession ID: Reactome:R-MMU-1430728		 -
Biological oxidations

Accession ID: Reactome:R-MMU-211859		 -
FMO oxidises nucleophiles

Accession ID: Reactome:R-MMU-217271
  • 10.1016/j.pharmthera.2005.01.001
 Krueger SK, Williams DE. Mammalian flavin-containing monooxygenases: structure/function, genetic polymorphisms and role in drug metabolism. Pharmacology & Therapeutics. 2005 Jun;106(3):357–87. doi: 10.1016/j.pharmthera.2005.01.001.; Cashman JR. The role of flavin-containing monooxygenases in drug metabolism and development. Curr Opin Drug Discov Devel. 2003 Jul;6(4):486–93. PMID: 12951812.
Phase I - Functionalization of compounds

Accession ID: Reactome:R-RNO-211945
  • 10.1208/aapsj080112
  • 10.1517/17425255.2.6.895
  • 10.2174/1389200023337054
 Strolin Benedetti M, Whomsley R, Baltes E. Involvement of enzymes other than CYPs in the oxidative metabolism of xenobiotics. Expert Opinion on Drug Metabolism & Toxicology. 2006 Nov 24;2(6):895–921. doi: 10.1517/17425255.2.6.895.; Guengerich FP. Cytochrome P450s and other enzymes in drug metabolism and toxicity. The AAPS Journal. 2006 Mar 01;8(1):e101–11. doi: 10.1208/aapsj080112.; Danielson PB. The cytochrome P450 superfamily: biochemistry, evolution and drug metabolism in humans. Curr Drug Metab. 2002 Dec;3(6):561–97. doi: 10.2174/1389200023337054. PMID: 12369887.
Phase I - Functionalization of compounds

Accession ID: Reactome:R-SSC-211945
  • 10.1208/aapsj080112
  • 10.1517/17425255.2.6.895
  • 10.2174/1389200023337054
 Strolin Benedetti M, Whomsley R, Baltes E. Involvement of enzymes other than CYPs in the oxidative metabolism of xenobiotics. Expert Opinion on Drug Metabolism & Toxicology. 2006 Nov 24;2(6):895–921. doi: 10.1517/17425255.2.6.895.; Guengerich FP. Cytochrome P450s and other enzymes in drug metabolism and toxicity. The AAPS Journal. 2006 Mar 01;8(1):e101–11. doi: 10.1208/aapsj080112.; Danielson PB. The cytochrome P450 superfamily: biochemistry, evolution and drug metabolism in humans. Curr Drug Metab. 2002 Dec;3(6):561–97. doi: 10.2174/1389200023337054. PMID: 12369887.
Biological oxidations

Accession ID: Reactome:R-BTA-211859		 -
FMO oxidises nucleophiles

Accession ID: Reactome:R-BTA-217271
  • 10.1016/j.pharmthera.2005.01.001
 Krueger SK, Williams DE. Mammalian flavin-containing monooxygenases: structure/function, genetic polymorphisms and role in drug metabolism. Pharmacology & Therapeutics. 2005 Jun;106(3):357–87. doi: 10.1016/j.pharmthera.2005.01.001.; Cashman JR. The role of flavin-containing monooxygenases in drug metabolism and development. Curr Opin Drug Discov Devel. 2003 Jul;6(4):486–93. PMID: 12951812.
FMO oxidises nucleophiles

Accession ID: Reactome:R-CEL-217271
  • 10.1016/j.pharmthera.2005.01.001
 Krueger SK, Williams DE. Mammalian flavin-containing monooxygenases: structure/function, genetic polymorphisms and role in drug metabolism. Pharmacology & Therapeutics. 2005 Jun;106(3):357–87. doi: 10.1016/j.pharmthera.2005.01.001.; Cashman JR. The role of flavin-containing monooxygenases in drug metabolism and development. Curr Opin Drug Discov Devel. 2003 Jul;6(4):486–93. PMID: 12951812.
Phase I - Functionalization of compounds

Accession ID: Reactome:R-DRE-211945
  • 10.1208/aapsj080112
  • 10.1517/17425255.2.6.895
  • 10.2174/1389200023337054
 Strolin Benedetti M, Whomsley R, Baltes E. Involvement of enzymes other than CYPs in the oxidative metabolism of xenobiotics. Expert Opinion on Drug Metabolism & Toxicology. 2006 Nov 24;2(6):895–921. doi: 10.1517/17425255.2.6.895.; Guengerich FP. Cytochrome P450s and other enzymes in drug metabolism and toxicity. The AAPS Journal. 2006 Mar 01;8(1):e101–11. doi: 10.1208/aapsj080112.; Danielson PB. The cytochrome P450 superfamily: biochemistry, evolution and drug metabolism in humans. Curr Drug Metab. 2002 Dec;3(6):561–97. doi: 10.2174/1389200023337054. PMID: 12369887.
Biological oxidations

Accession ID: Reactome:R-RNO-211859		 -
FMO oxidises nucleophiles

Accession ID: Reactome:R-RNO-217271
  • 10.1016/j.pharmthera.2005.01.001
 Krueger SK, Williams DE. Mammalian flavin-containing monooxygenases: structure/function, genetic polymorphisms and role in drug metabolism. Pharmacology & Therapeutics. 2005 Jun;106(3):357–87. doi: 10.1016/j.pharmthera.2005.01.001.; Cashman JR. The role of flavin-containing monooxygenases in drug metabolism and development. Curr Opin Drug Discov Devel. 2003 Jul;6(4):486–93. PMID: 12951812.
Metabolism

Accession ID: Reactome:R-SSC-1430728		 -
Biological oxidations

Accession ID: Reactome:R-SSC-211859		 -
FMO oxidises nucleophiles

Accession ID: Reactome:R-SSC-217271
  • 10.1016/j.pharmthera.2005.01.001
 Krueger SK, Williams DE. Mammalian flavin-containing monooxygenases: structure/function, genetic polymorphisms and role in drug metabolism. Pharmacology & Therapeutics. 2005 Jun;106(3):357–87. doi: 10.1016/j.pharmthera.2005.01.001.; Cashman JR. The role of flavin-containing monooxygenases in drug metabolism and development. Curr Opin Drug Discov Devel. 2003 Jul;6(4):486–93. PMID: 12951812.