FMO oxidises nucleophiles

Krueger SK, Williams DE. Mammalian flavin-containing monooxygenases: structure/function, genetic polymorphisms and role in drug metabolism. Pharmacology & Therapeutics. 2005 Jun;106(3):357–87. doi: 10.1016/j.pharmthera.2005.01.001.; Cashman JR. The role of flavin-containing monooxygenases in drug metabolism and development. Curr Opin Drug Discov Devel. 2003 Jul;6(4):486–93. PMID: 12951812.

Metabolites

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Magnesium cation

Formula: Mg (23.98505)

CAS ID: 22537-22-0

NADP+

Formula: C21H29N7O17P3 (744.0832754)

CAS ID: 53-59-8

NADPH

Formula: C21H30N7O17P3 (745.0911)

CAS ID: 2646-71-1

Oxygen

Formula: O2 (31.98983)

CAS ID: 7782-44-7

Tamoxifen

Formula: C26H29NO (371.2249024)

CAS ID: 10540-29-1

Tamoxifen N-oxide

Formula: C26H29NO2 (387.2198174)

CAS ID: 75504-34-6

Thiamazole

Formula: C4H6N2S (114.02516759999999)

CAS ID: 60-56-0

Trimethylamine

Formula: C3H9N (59.0734954)

CAS ID: 75-50-3

Trimethylamine N-oxide

Formula: C3H9NO (75.0684104)

CAS ID: 1184-78-7



Enzyme

EC Number name full name note
1.14.13.148 trimethylamine monooxygenase N,N,N-trimethylamine,NADPH:oxygen oxidoreductase (N-oxide-forming)
1.14.13.32 albendazole monooxygenase albendazole,NADPH:oxygen oxidoreductase (sulfoxide-forming)
1.14.13.8 flavin-containing monooxygenase N,N-dimethylaniline,NADPH:oxygen oxidoreductase (N-oxide-forming)


Proteins

Protein ID name full name