Pathways Knowlegdes
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| Pathway | DOIs | Note |
|---|---|---|
| Conjugation of phenylacetate with glutamine Accession ID: Reactome:R-GGA-177162 |
|
Vessey DA, Lau E, Kelley M, Warren RS. Isolation, sequencing, and expression of a cDNA for the HXM-A form of xenobiotic/medium-chain fatty acid:CoA ligase from human liver mitochondria. J Biochem Mol Toxicol. 2003;17(1):1–6. doi: 10.1002/jbt.10056. PMID: 12616642.; Fujino T, Takei YA, Sone H, Ioka RX, Kamataki A, Magoori K, Takahashi S, Sakai J, Yamamoto TT. Molecular Identification and Characterization of Two Medium-chain Acyl-CoA Synthetases, MACS1 and the Sa Gene Product. Journal of Biological Chemistry. 2001 Sep;276(38):35961–6. doi: 10.1074/jbc.m106651200.; Batshaw ML, MacArthur RB, Tuchman M. Alternative pathway therapy for urea cycle disorders: twenty years later. J Pediatr. 2001 Jan;138(1 Suppl):S46–54; discussion S54. doi: 10.1067/mpd.2001.111836. PMID: 11148549.; Vessey DA, Kelley M, Warren RS. Characterization of the CoA ligases of human liver mitochondria catalyzing the activation of short- and medium-chain fatty acids and xenobiotic carboxylic acids. Biochimica et Biophysica Acta (BBA) - General Subjects. 1999 Aug;1428(2-3):455–62. doi: 10.1016/s0304-4165(99)00088-4.; Webster LT, Siddiqui UA, Lucas SV, Strong JM, Mieyal JJ. Identification of separate acyl- CoA:glycine and acyl-CoA:L-glutamine N-acyltransferase activities in mitochondrial fractions from liver of rhesus monkey and man. Journal of Biological Chemistry. 1976 Jun;251(11):3352–8. doi: 10.1016/s0021-9258(17)33444-0.; James MO, Smith RL, Williams RT, Reidenberg M. The conjugation of phenylacetic acid in man, sub-human primates and some non-primate species. Proc R Soc Lond B Biol Sci. 1972 Jul 25;182(1066):25–35. doi: 10.1098/rspb.1972.0064. PMID: 4403084. |
| Conjugation of phenylacetate with glutamine Accession ID: Reactome:R-XTR-177162 |
|
Vessey DA, Lau E, Kelley M, Warren RS. Isolation, sequencing, and expression of a cDNA for the HXM-A form of xenobiotic/medium-chain fatty acid:CoA ligase from human liver mitochondria. J Biochem Mol Toxicol. 2003;17(1):1–6. doi: 10.1002/jbt.10056. PMID: 12616642.; Fujino T, Takei YA, Sone H, Ioka RX, Kamataki A, Magoori K, Takahashi S, Sakai J, Yamamoto TT. Molecular Identification and Characterization of Two Medium-chain Acyl-CoA Synthetases, MACS1 and the Sa Gene Product. Journal of Biological Chemistry. 2001 Sep;276(38):35961–6. doi: 10.1074/jbc.m106651200.; Batshaw ML, MacArthur RB, Tuchman M. Alternative pathway therapy for urea cycle disorders: twenty years later. J Pediatr. 2001 Jan;138(1 Suppl):S46–54; discussion S54. doi: 10.1067/mpd.2001.111836. PMID: 11148549.; Vessey DA, Kelley M, Warren RS. Characterization of the CoA ligases of human liver mitochondria catalyzing the activation of short- and medium-chain fatty acids and xenobiotic carboxylic acids. Biochimica et Biophysica Acta (BBA) - General Subjects. 1999 Aug;1428(2-3):455–62. doi: 10.1016/s0304-4165(99)00088-4.; Webster LT, Siddiqui UA, Lucas SV, Strong JM, Mieyal JJ. Identification of separate acyl- CoA:glycine and acyl-CoA:L-glutamine N-acyltransferase activities in mitochondrial fractions from liver of rhesus monkey and man. Journal of Biological Chemistry. 1976 Jun;251(11):3352–8. doi: 10.1016/s0021-9258(17)33444-0.; James MO, Smith RL, Williams RT, Reidenberg M. The conjugation of phenylacetic acid in man, sub-human primates and some non-primate species. Proc R Soc Lond B Biol Sci. 1972 Jul 25;182(1066):25–35. doi: 10.1098/rspb.1972.0064. PMID: 4403084. |
| Amino Acid conjugation Accession ID: Reactome:R-GGA-156587 |
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| Amino Acid conjugation Accession ID: Reactome:R-XTR-156587 |
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| Conjugation of carboxylic acids Accession ID: Reactome:R-GGA-159424 |
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| Conjugation of phenylacetate with glutamine Accession ID: Reactome:R-DRE-177162 |
|
Vessey DA, Lau E, Kelley M, Warren RS. Isolation, sequencing, and expression of a cDNA for the HXM-A form of xenobiotic/medium-chain fatty acid:CoA ligase from human liver mitochondria. J Biochem Mol Toxicol. 2003;17(1):1–6. doi: 10.1002/jbt.10056. PMID: 12616642.; Fujino T, Takei YA, Sone H, Ioka RX, Kamataki A, Magoori K, Takahashi S, Sakai J, Yamamoto TT. Molecular Identification and Characterization of Two Medium-chain Acyl-CoA Synthetases, MACS1 and the Sa Gene Product. Journal of Biological Chemistry. 2001 Sep;276(38):35961–6. doi: 10.1074/jbc.m106651200.; Batshaw ML, MacArthur RB, Tuchman M. Alternative pathway therapy for urea cycle disorders: twenty years later. J Pediatr. 2001 Jan;138(1 Suppl):S46–54; discussion S54. doi: 10.1067/mpd.2001.111836. PMID: 11148549.; Vessey DA, Kelley M, Warren RS. Characterization of the CoA ligases of human liver mitochondria catalyzing the activation of short- and medium-chain fatty acids and xenobiotic carboxylic acids. Biochimica et Biophysica Acta (BBA) - General Subjects. 1999 Aug;1428(2-3):455–62. doi: 10.1016/s0304-4165(99)00088-4.; Webster LT, Siddiqui UA, Lucas SV, Strong JM, Mieyal JJ. Identification of separate acyl- CoA:glycine and acyl-CoA:L-glutamine N-acyltransferase activities in mitochondrial fractions from liver of rhesus monkey and man. Journal of Biological Chemistry. 1976 Jun;251(11):3352–8. doi: 10.1016/s0021-9258(17)33444-0.; James MO, Smith RL, Williams RT, Reidenberg M. The conjugation of phenylacetic acid in man, sub-human primates and some non-primate species. Proc R Soc Lond B Biol Sci. 1972 Jul 25;182(1066):25–35. doi: 10.1098/rspb.1972.0064. PMID: 4403084. |
| Conjugation of carboxylic acids Accession ID: Reactome:R-XTR-159424 |
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| Metabolism Accession ID: Reactome:R-BTA-1430728 |
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| Metabolism Accession ID: Reactome:R-CFA-1430728 |
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| Phase II - Conjugation of compounds Accession ID: Reactome:R-CFA-156580 |
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McCarver DG, Hines RN. The Ontogeny of Human Drug-Metabolizing Enzymes: Phase II Conjugation Enzymes and Regulatory Mechanisms. The Journal of Pharmacology and Experimental Therapeutics. 2002 Feb;300(2):361–6. doi: 10.1124/jpet.300.2.361. |
| Conjugation of carboxylic acids Accession ID: Reactome:R-CFA-159424 |
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| Phase II - Conjugation of compounds Accession ID: Reactome:R-GGA-156580 |
|
McCarver DG, Hines RN. The Ontogeny of Human Drug-Metabolizing Enzymes: Phase II Conjugation Enzymes and Regulatory Mechanisms. The Journal of Pharmacology and Experimental Therapeutics. 2002 Feb;300(2):361–6. doi: 10.1124/jpet.300.2.361. |
| Biological oxidations Accession ID: Reactome:R-HSA-211859 |
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| Conjugation of carboxylic acids Accession ID: Reactome:R-HSA-159424 |
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| Metabolism Accession ID: Reactome:R-MMU-1430728 |
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| Biological oxidations Accession ID: Reactome:R-MMU-211859 |
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| Conjugation of carboxylic acids Accession ID: Reactome:R-MMU-159424 |
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| Biological oxidations Accession ID: Reactome:R-BTA-211859 |
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| Conjugation of carboxylic acids Accession ID: Reactome:R-BTA-159424 |
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| Amino Acid conjugation Accession ID: Reactome:R-CFA-156587 |
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