Pathways Knowlegdes

Necessitatibus eius consequatur ex aliquid fuga eum quidem sint consectetur velit

Pathway DOIs Note
Metabolism

Accession ID: Reactome:R-BTA-1430728		 -
Phase I - Functionalization of compounds

Accession ID: Reactome:R-BTA-211945
  • 10.1208/aapsj080112
  • 10.1517/17425255.2.6.895
  • 10.2174/1389200023337054
 Strolin Benedetti M, Whomsley R, Baltes E. Involvement of enzymes other than CYPs in the oxidative metabolism of xenobiotics. Expert Opinion on Drug Metabolism & Toxicology. 2006 Nov 24;2(6):895–921. doi: 10.1517/17425255.2.6.895.; Guengerich FP. Cytochrome P450s and other enzymes in drug metabolism and toxicity. The AAPS Journal. 2006 Mar 01;8(1):e101–11. doi: 10.1208/aapsj080112.; Danielson PB. The cytochrome P450 superfamily: biochemistry, evolution and drug metabolism in humans. Curr Drug Metab. 2002 Dec;3(6):561–97. doi: 10.2174/1389200023337054. PMID: 12369887.
Xenobiotics

Accession ID: Reactome:R-BTA-211981
  • 10.1208/aapsj080112
  • 10.1517/phgs.5.3.305.29827
  • 10.2174/1389200023337054
 Guengerich FP. Cytochrome P450s and other enzymes in drug metabolism and toxicity. The AAPS Journal. 2006 Mar 01;8(1):e101–11. doi: 10.1208/aapsj080112.; Lewis DF. 57 varieties: the human cytochromes P450. Pharmacogenomics. 2004 Apr;5(3):305–18. doi: 10.1517/phgs.5.3.305.29827. PMID: 15102545.; Danielson PB. The cytochrome P450 superfamily: biochemistry, evolution and drug metabolism in humans. Curr Drug Metab. 2002 Dec;3(6):561–97. doi: 10.2174/1389200023337054. PMID: 12369887.
Biological oxidations

Accession ID: Reactome:R-CEL-211859		 -
Aryl hydrocarbon receptor signalling

Accession ID: Reactome:R-CEL-8937144
  • 10.1016/j.bcp.2008.09.016
  • 10.1515/bc.2006.147
  • 10.1615/critreveukargeneexpr.v18.i3.20
 Hahn ME, Allan LL, Sherr DH. Regulation of constitutive and inducible AHR signaling: Complex interactions involving the AHR repressor. Biochemical Pharmacology. 2009 Feb;77(4):485–97. doi: 10.1016/j.bcp.2008.09.016.; Beischlag TV, Morales JL, Hollingshead BD, Perdew GH. The Aryl Hydrocarbon Receptor Complex and the Control of Gene Expression. Crit Rev Eukar Gene Expr. 2008;18(3):207–50. doi: 10.1615/critreveukargeneexpr.v18.i3.20.; Haarmann-Stemmann T, Abel J. The arylhydrocarbon receptor repressor (AhRR): structure, expression, and function. Biol Chem. 2006 Sep;387(9):1195–9. doi: 10.1515/bc.2006.147. PMID: 16972786.
Metabolism

Accession ID: Reactome:R-CFA-1430728		 -
Endogenous sterols

Accession ID: Reactome:R-CFA-211976
  • 10.1016/j.pharmthera.2006.05.014
  • 10.1208/aapsj080112
  • 10.1517/phgs.5.3.305.29827
 Pikuleva IA. Cytochrome P450s and cholesterol homeostasis. Pharmacol Ther. 2006 Dec;112(3):761–73. doi: 10.1016/j.pharmthera.2006.05.014. PMID: 16872679.; Guengerich FP. Cytochrome P450s and other enzymes in drug metabolism and toxicity. The AAPS Journal. 2006 Mar 01;8(1):e101–11. doi: 10.1208/aapsj080112.; Lewis DF. 57 varieties: the human cytochromes P450. Pharmacogenomics. 2004 Apr;5(3):305–18. doi: 10.1517/phgs.5.3.305.29827. PMID: 15102545.
Aryl hydrocarbon receptor signalling

Accession ID: Reactome:R-DME-8937144
  • 10.1016/j.bcp.2008.09.016
  • 10.1515/bc.2006.147
  • 10.1615/critreveukargeneexpr.v18.i3.20
 Hahn ME, Allan LL, Sherr DH. Regulation of constitutive and inducible AHR signaling: Complex interactions involving the AHR repressor. Biochemical Pharmacology. 2009 Feb;77(4):485–97. doi: 10.1016/j.bcp.2008.09.016.; Beischlag TV, Morales JL, Hollingshead BD, Perdew GH. The Aryl Hydrocarbon Receptor Complex and the Control of Gene Expression. Crit Rev Eukar Gene Expr. 2008;18(3):207–50. doi: 10.1615/critreveukargeneexpr.v18.i3.20.; Haarmann-Stemmann T, Abel J. The arylhydrocarbon receptor repressor (AhRR): structure, expression, and function. Biol Chem. 2006 Sep;387(9):1195–9. doi: 10.1515/bc.2006.147. PMID: 16972786.
Endogenous sterols

Accession ID: Reactome:R-GGA-211976
  • 10.1016/j.pharmthera.2006.05.014
  • 10.1208/aapsj080112
  • 10.1517/phgs.5.3.305.29827
 Pikuleva IA. Cytochrome P450s and cholesterol homeostasis. Pharmacol Ther. 2006 Dec;112(3):761–73. doi: 10.1016/j.pharmthera.2006.05.014. PMID: 16872679.; Guengerich FP. Cytochrome P450s and other enzymes in drug metabolism and toxicity. The AAPS Journal. 2006 Mar 01;8(1):e101–11. doi: 10.1208/aapsj080112.; Lewis DF. 57 varieties: the human cytochromes P450. Pharmacogenomics. 2004 Apr;5(3):305–18. doi: 10.1517/phgs.5.3.305.29827. PMID: 15102545.
Regulation of lipid metabolism by PPARalpha

Accession ID: Reactome:R-HSA-400206
  • 10.1016/j.plipres.2005.12.002
  • 10.1155/2008/132960
  • 10.1210/edrv.20.5.0380
  • 10.2174/156800605774962022
 Kersten S. Peroxisome proliferator activated receptors and lipoprotein metabolism. PPAR Res. 2008;2008():132960. PMID: 18288277; PMCID: PMC2220040.; Feige JN, Gelman L, Michalik L, Desvergne B, Wahli W. From molecular action to physiological outputs: peroxisome proliferator-activated receptors are nuclear receptors at the crossroads of key cellular functions. Prog Lipid Res. 2006 Mar;45(2):120–59. doi: 10.1016/j.plipres.2005.12.002. PMID: 16476485.; Gouni-Berthold I, Krone W. Peroxisome proliferator-activated receptor alpha (PPARalpha) and athero-sclerosis. Curr Drug Targets Cardiovasc Haematol Disord. 2005 Dec;5(6):513–23. doi: 10.2174/156800605774962022. PMID: 16503871.; Desvergne B, Wahli W. Peroxisome proliferator-activated receptors: nuclear control of metabolism. Endocr Rev. 1999 Oct;20(5):649–88. doi: 10.1210/edrv.20.5.0380. PMID: 10529898.
Biological oxidations

Accession ID: Reactome:R-HSA-211859		 -
Metabolism

Accession ID: Reactome:R-MMU-1430728		 -
Biological oxidations

Accession ID: Reactome:R-MMU-211859		 -
Phase I - Functionalization of compounds

Accession ID: Reactome:R-RNO-211945
  • 10.1208/aapsj080112
  • 10.1517/17425255.2.6.895
  • 10.2174/1389200023337054
 Strolin Benedetti M, Whomsley R, Baltes E. Involvement of enzymes other than CYPs in the oxidative metabolism of xenobiotics. Expert Opinion on Drug Metabolism & Toxicology. 2006 Nov 24;2(6):895–921. doi: 10.1517/17425255.2.6.895.; Guengerich FP. Cytochrome P450s and other enzymes in drug metabolism and toxicity. The AAPS Journal. 2006 Mar 01;8(1):e101–11. doi: 10.1208/aapsj080112.; Danielson PB. The cytochrome P450 superfamily: biochemistry, evolution and drug metabolism in humans. Curr Drug Metab. 2002 Dec;3(6):561–97. doi: 10.2174/1389200023337054. PMID: 12369887.
Xenobiotics

Accession ID: Reactome:R-RNO-211981
  • 10.1208/aapsj080112
  • 10.1517/phgs.5.3.305.29827
  • 10.2174/1389200023337054
 Guengerich FP. Cytochrome P450s and other enzymes in drug metabolism and toxicity. The AAPS Journal. 2006 Mar 01;8(1):e101–11. doi: 10.1208/aapsj080112.; Lewis DF. 57 varieties: the human cytochromes P450. Pharmacogenomics. 2004 Apr;5(3):305–18. doi: 10.1517/phgs.5.3.305.29827. PMID: 15102545.; Danielson PB. The cytochrome P450 superfamily: biochemistry, evolution and drug metabolism in humans. Curr Drug Metab. 2002 Dec;3(6):561–97. doi: 10.2174/1389200023337054. PMID: 12369887.
Phase I - Functionalization of compounds

Accession ID: Reactome:R-SSC-211945
  • 10.1208/aapsj080112
  • 10.1517/17425255.2.6.895
  • 10.2174/1389200023337054
 Strolin Benedetti M, Whomsley R, Baltes E. Involvement of enzymes other than CYPs in the oxidative metabolism of xenobiotics. Expert Opinion on Drug Metabolism & Toxicology. 2006 Nov 24;2(6):895–921. doi: 10.1517/17425255.2.6.895.; Guengerich FP. Cytochrome P450s and other enzymes in drug metabolism and toxicity. The AAPS Journal. 2006 Mar 01;8(1):e101–11. doi: 10.1208/aapsj080112.; Danielson PB. The cytochrome P450 superfamily: biochemistry, evolution and drug metabolism in humans. Curr Drug Metab. 2002 Dec;3(6):561–97. doi: 10.2174/1389200023337054. PMID: 12369887.
Xenobiotics

Accession ID: Reactome:R-SSC-211981
  • 10.1208/aapsj080112
  • 10.1517/phgs.5.3.305.29827
  • 10.2174/1389200023337054
 Guengerich FP. Cytochrome P450s and other enzymes in drug metabolism and toxicity. The AAPS Journal. 2006 Mar 01;8(1):e101–11. doi: 10.1208/aapsj080112.; Lewis DF. 57 varieties: the human cytochromes P450. Pharmacogenomics. 2004 Apr;5(3):305–18. doi: 10.1517/phgs.5.3.305.29827. PMID: 15102545.; Danielson PB. The cytochrome P450 superfamily: biochemistry, evolution and drug metabolism in humans. Curr Drug Metab. 2002 Dec;3(6):561–97. doi: 10.2174/1389200023337054. PMID: 12369887.
Aryl hydrocarbon receptor signalling

Accession ID: Reactome:R-XTR-8937144
  • 10.1016/j.bcp.2008.09.016
  • 10.1515/bc.2006.147
  • 10.1615/critreveukargeneexpr.v18.i3.20
 Hahn ME, Allan LL, Sherr DH. Regulation of constitutive and inducible AHR signaling: Complex interactions involving the AHR repressor. Biochemical Pharmacology. 2009 Feb;77(4):485–97. doi: 10.1016/j.bcp.2008.09.016.; Beischlag TV, Morales JL, Hollingshead BD, Perdew GH. The Aryl Hydrocarbon Receptor Complex and the Control of Gene Expression. Crit Rev Eukar Gene Expr. 2008;18(3):207–50. doi: 10.1615/critreveukargeneexpr.v18.i3.20.; Haarmann-Stemmann T, Abel J. The arylhydrocarbon receptor repressor (AhRR): structure, expression, and function. Biol Chem. 2006 Sep;387(9):1195–9. doi: 10.1515/bc.2006.147. PMID: 16972786.
Biological oxidations

Accession ID: Reactome:R-BTA-211859		 -
Cytochrome P450 - arranged by substrate type

Accession ID: Reactome:R-CFA-211897
  • 10.1097/00008571-200401000-00001
  • 10.1208/aapsj080112
  • 10.1517/phgs.5.3.305.29827
  • 10.2174/1389200023337054
 Guengerich FP. Cytochrome P450s and other enzymes in drug metabolism and toxicity. The AAPS Journal. 2006 Mar 01;8(1):e101–11. doi: 10.1208/aapsj080112.; Lewis DF. 57 varieties: the human cytochromes P450. Pharmacogenomics. 2004 Apr;5(3):305–18. doi: 10.1517/phgs.5.3.305.29827. PMID: 15102545.; Nelson DR, Zeldin DC, Hoffman SM, Maltais LJ, Wain HM, Nebert DW. Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants. Pharmacogenetics. 2004 Jan;14(1):1–18. doi: 10.1097/00008571-200401000-00001. PMID: 15128046.; Danielson PB. The cytochrome P450 superfamily: biochemistry, evolution and drug metabolism in humans. Curr Drug Metab. 2002 Dec;3(6):561–97. doi: 10.2174/1389200023337054. PMID: 12369887.