L-methionine biosynthesis IV (archaea)

Allen KD, Miller DV, Rauch BJ, Perona JJ, White RH. Homocysteine is biosynthesized from aspartate semialdehyde and hydrogen sulfide in methanogenic archaea. Biochemistry. 2015 May 26;54(20):3129–32. doi: 10.1021/acs.biochem.5b00118. PMID: 25938369.

Metabolites

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Hydrogen sulfide

Formula: H2S (33.9877212)

CAS ID: 7783-06-4

Magnesium cation

Formula: Mg (23.98505)

CAS ID: 22537-22-0

L-aspartate(1-)

Formula: C4H6NO4 (132.0296816)

CAS ID:

NADPH(4-)

Formula: C21H26N7O17P3 (741.0598016)

CAS ID: 53-57-6

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

4-phosphonato-L-aspartic acid(2-)

Formula: C4H6NO7P (210.98818959999997)

CAS ID:

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:

NADP(3-)

Formula: C21H25N7O17P3 (740.051977)

CAS ID: 53-59-8



Enzyme

EC Number name full name note
2.1.1.-
1.2.1.11 aspartate-semialdehyde dehydrogenase L-aspartate-4-semialdehyde:NADP+ oxidoreductase (phosphorylating)
2.7.2.4 aspartate kinase ATP:L-aspartate 4-phosphotransferase
2.8.1.16 L-aspartate semialdehyde sulfurtransferase hydrogen sulfide:L-aspartate-4-semialdehyde sulfurtransferase


Proteins

Protein ID name full name
P55299 metE Methionine synthase
Q57658 asd Aspartate-semialdehyde dehydrogenase
Q57991 AK_METJA Probable aspartokinase
Q8TPT4 MA_1821 conserved hypothetical protein