D-galactose degradation V (Leloir pathway)

Majumdar S, Ghatak J, Mukherji S, Bhattacharjee H, Bhaduri A. UDPgalactose 4-epimerase from Saccharomyces cerevisiae. A bifunctional enzyme with aldose 1-epimerase activity. Eur J Biochem. 2004 Feb;271(4):753–9. doi: 10.1111/j.1432-1033.2003.03974.x. PMID: 14764091.

Metabolites

alpha-D-Galactose

Formula: C6H12O6 (180.0633852)

CAS ID: 3646-73-9

beta-D-Galactose

Formula: C6H12O6 (180.0633852)

CAS ID: 7296-64-2

D-Glucose 6-phosphate

Formula: C6H13O9P (260.0297178)

CAS ID: 56-73-5

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

Lithium

Formula: Li (7.016005)

CAS ID: 7439-93-2

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

UDP-alpha-D-glucose(2-)

Formula: C15H22N2O17P2 (564.0393702)

CAS ID:

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:



Enzyme

EC Number name full name note
2.7.1.6 galactokinase ATP:D-galactose 1-phosphotransferase
2.7.7.12 UDP-glucose-hexose-1-phosphate uridylyltransferase UDP-glucose:alpha-D-galactose-1-phosphate uridylyltransferase
5.1.3.2 UDP-glucose 4-epimerase UDP-glucose 4-epimerase
5.1.3.3 Aldose 1-epimerase Aldose 1-epimerase
5.4.2.2 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) alpha-D-glucose 1,6-phosphomutase


Proteins

Protein ID name full name
P04385 GAL1 Galactokinase
P04397 GAL10 Bifunctional protein GAL10
P08431 GAL7 Galactose-1-phosphate uridylyltransferase
P33401 PGM1 Phosphoglucomutase 1
P37012 PGM2 Phosphoglucomutase 2