superpathway of purine nucleotide salvage
Bzowska A, Kulikowska E, Shugar D. Purine nucleoside phosphorylases: properties, functions, and clinical aspects. Pharmacol Ther. 2000 Dec;88(3):349–425. doi: 10.1016/s0163-7258(00)00097-8. PMID: 11337031.; Spychala J, Datta NS, Takabayashi K, Datta M, Fox IH, Gribbin T, Mitchell BS. Cloning of human adenosine kinase cDNA: sequence similarity to microbial ribokinases and fructokinases. Proc. Natl. Acad. Sci. U.S.A. 1996 Feb 06;93(3):1232–7. doi: 10.1073/pnas.93.3.1232.; Lewis AS, Lowy BA. Human erythrocyte purine nucleoside phosphorylase: molecular weight and physical properties. A Theorell-Chance catalytic mechanism. Journal of Biological Chemistry. 1979 Oct;254(19):9927–32. doi: 10.1016/s0021-9258(19)83606-2.
Metabolites
Enzyme
| EC Number | name | full name | note |
|---|---|---|---|
| 1.1.1.205 | IMP dehydrogenase | IMP:NAD+ oxidoreductase | |
| 1.17.4.1 | ribonucleoside-diphosphate reductase | 2'-deoxyribonucleoside-5'-diphosphate:thioredoxin-disulfide 2'-oxidoreductase | |
| 2.4.2.1 | purine-nucleoside phosphorylase | purine-nucleoside:phosphate ribosyltransferase | |
| 2.4.2.8 | hypoxanthine phosphoribosyltransferase | IMP:diphosphate phospho-D-ribosyltransferase | |
| 2.7.1.20 | adenosine kinase | ATP:adenosine 5'-phosphotransferase | |
| 2.7.13.3 | histidine kinase | ATP:protein-L-histidine N-phosphotransferase | |
| 2.7.4.3 | adenylate kinase | ATP:AMP phosphotransferase | |
| 2.7.4.6 | nucleoside-diphosphate kinase | ATP:nucleoside-diphosphate phosphotransferase | |
| 2.7.4.8 | guanylate kinase | ATP:(d)GMP phosphotransferase | |
| 3.5.4.4 | adenosine deaminase | adenosine aminohydrolase | |
| 4.3.2.2 | adenylosuccinate lyase | N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) |
Proteins
| Protein ID | name | full name |
|---|