superpathway of N-acetylneuraminate degradation

Byers HL, Homer KA, Beighton D. Utilization of sialic acid by viridans streptococci. J Dent Res. 1996 Aug;75(8):1564–71. doi: 10.1177/00220345960750080701. PMID: 8906124.

Metabolites

Acetaldehyde

Formula: C2H4O (44.0262134)

CAS ID: 75-07-0

Aromatic aldehyde

Formula: C7H6O (106.0418626)

CAS ID: 100-52-7

Calcium cation

Formula: Ca (39.962591)

CAS ID: 14127-61-8

Copper

Formula: Cu (62.929599)

CAS ID: 7440-50-8

Diethyl pyrocarbonate

Formula: C6H10O5 (162.052821)

CAS ID: 1609-47-8

Dithiothreitol

Formula: C4H10O2S2 (154.01222)

CAS ID: 3483-12-3

Ethanol

Formula: C2H6O (46.0418626)

CAS ID: 64-17-5

Fe2+

Formula: Fe (55.934939)

CAS ID: 15438-31-0

Fluoride

Formula: F (18.9984032)

CAS ID: 7782-41-4

Fomepizole

Formula: C4H6N2 (82.05309559999999)

CAS ID: 7554-65-6

Glyceraldehyde

Formula: C3H6O3 (90.0316926)

CAS ID: 367-47-5

Glycerone

Formula: C3H6O3 (90.0316926)

CAS ID: 96-26-4

Guaiacol

Formula: C7H8O2 (124.05242679999999)

CAS ID: 90-05-1

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Lithium

Formula: Li (7.016005)

CAS ID: 7439-93-2

Magnesium cation

Formula: Mg (23.98505)

CAS ID: 22537-22-0

Manganese(2+)

Formula: Mn (54.938046)

CAS ID: 7439-96-5

Nickel(2+)

Formula: Ni (57.935347)

CAS ID: 14701-22-5

Oxygen

Formula: O2 (31.98983)

CAS ID: 7782-44-7

Potassium cation

Formula: K (38.963708)

CAS ID: 24203-36-9

Pyrazole

Formula: C3H4N2 (68.0374464)

CAS ID: 288-13-1

Sulfate

Formula: H2SO4 (97.9673812)

CAS ID: 7664-93-9

Zinc cation

Formula: Zn (63.929145)

CAS ID: 23713-49-7

Potassium chloride

Formula: ClK (73.93256099999999)

CAS ID: 7447-40-7

formate

Formula: CHO2 (44.997654600000004)

CAS ID: 71-47-6

oxaloacetate(2-)

Formula: C4H2O5 (129.9902242)

CAS ID: 149-63-3

2-oxoglutarate(2-)

Formula: C5H4O5 (144.00587339999998)

CAS ID: 64-15-3

oxalate(2-)

Formula: C2O4 (87.97966)

CAS ID: 338-70-5

acetate

Formula: C2H3O2 (59.0133038)

CAS ID: 71-50-1

pyruvate

Formula: C3H3O3 (87.00821880000001)

CAS ID: 57-60-3

methacrylate

Formula: C4H5O2 (85.028953)

CAS ID: 18358-13-9

citrate(3-)

Formula: C6H5O7 (189.00352800000002)

CAS ID: 126-44-3

NADPH(4-)

Formula: C21H26N7O17P3 (741.0598016)

CAS ID: 53-57-6

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

NAD(1-)

Formula: C21H26N7O14P2 (662.1012936000001)

CAS ID: 53-84-9

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:

borohydride

Formula: BH4 (15.040603399999998)

CAS ID: 16971-29-2

N-bromosuccinimide

Formula: C4H4BrNO2 (176.9425384)

CAS ID: 128-08-5



Enzyme

EC Number name full name note
2.3.1.-
1.1.1.1 alcohol dehydrogenase alcohol:NAD+ oxidoreductase
1.2.1.10 acetaldehyde dehydrogenase (acetylating) acetaldehyde:NAD+ oxidoreductase (CoA-acetylating)
1.2.1.12 glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) D-glyceraldehyde-3-phosphate:NAD+ oxidoreductase (phosphorylating)
2.3.1.54 formate C-acetyltransferase acetyl-CoA:formate C-acetyltransferase
2.3.1.8 phosphate acetyltransferase acetyl-CoA:phosphate acetyltransferase
2.7.1.11 6-phosphofructokinase ATP:D-fructose-6-phosphate 1-phosphotransferase
2.7.1.40 pyruvate kinase ATP:pyruvate 2-O-phosphotransferase
2.7.1.60 N-acylmannosamine kinase ATP:N-acyl-D-mannosamine 6-phosphotransferase
2.7.2.1 acetate kinase ATP:acetate phosphotransferase
2.7.2.3 phosphoglycerate kinase ATP:3-phospho-D-glycerate 1-phosphotransferase
2.7.9.2 pyruvate, water dikinase ATP:pyruvate,water phosphotransferase
3.1.3.1 alkaline phosphatase phosphate-monoester phosphohydrolase (alkaline optimum)
3.1.3.11 fructose-bisphosphatase D-fructose-1,6-bisphosphate 1-phosphohydrolase
3.1.3.74 pyridoxal phosphatase pyridoxal-5'-phosphate phosphohydrolase
3.5.1.25 N-acetylglucosamine-6-phosphate deacetylase N-acetyl-D-glucosamine-6-phosphate amidohydrolase
3.5.99.6 glucosamine-6-phosphate deaminase 2-amino-2-deoxy-D-glucose-6-phosphate aminohydrolase (ketol isomerizing)
4.1.2.13 fructose-bisphosphate aldolase D-fructose-1,6-bisphosphate D-glyceraldehyde-3-phosphate-lyase (glycerone-phosphate-forming)
4.1.3.3 N-acetylneuraminate lyase aceneuramate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
4.2.1.11 phosphopyruvate hydratase 2-phospho-D-glycerate hydro-lyase (phosphoenolpyruvate-forming)
5.1.3.9 N-acylglucosamine-6-phosphate 2-epimerase N-acyl-D-glucosamine-6-phosphate 2-epimerase
5.3.1.1 triose-phosphate isomerase D-glyceraldehyde-3-phosphate aldose-ketose-isomerase
5.4.2.11 phosphoglycerate mutase (2,3-diphosphoglycerate-dependent) D-phosphoglycerate 2,3-phosphomutase (2,3-diphosphoglycerate-dependent)
5.4.2.12 phosphoglycerate mutase (2,3-diphosphoglycerate-independent) D-phosphoglycerate 2,3-phosphomutase (2,3-diphosphoglycerate-independent)
6.3.1.21 phosphoribosylglycinamide formyltransferase 2 formate:N1-(5-phospho-beta-D-ribosyl)glycinamide ligase (ADP-forming)


Proteins

Protein ID name full name
A3CLX4 nagB Glucosamine-6-phosphate deaminase, putative
P00634 phoA Alkaline phosphatase
P06999 pfkB ATP-dependent 6-phosphofructokinase isozyme 2
P09373 pflB Formate acetyltransferase 1
P0A6A3 ackA Acetate kinase
P0A6L4 nanA N-acetylneuraminate lyase
P0A6P9 eno Enolase
P0A759 nagB Glucosamine-6-phosphate deaminase
P0A761 nanE Putative N-acetylmannosamine-6-phosphate 2-epimerase
P0A796 pfkA ATP-dependent 6-phosphofructokinase isozyme 1
P0A799 pgk Phosphoglycerate kinase
P0A858 tpiA Triosephosphate isomerase
P0A991 fbaB Fructose-bisphosphate aldolase class 1
P0A993 fbp Fructose-1,6-bisphosphatase class 1
P0A9B2 gapA Glyceraldehyde-3-phosphate dehydrogenase A
P0A9C9 glpX Fructose-1,6-bisphosphatase 1 class 2
P0A9M8 pta Phosphate acetyltransferase
P0A9Q7 adhE Bifunctional aldehyde-alcohol dehydrogenase AdhE
P0AB71 fbaA Fructose-bisphosphate aldolase class 2
P0AD61 pykF Pyruvate kinase I
P0AF18 nagA N-acetylglucosamine-6-phosphate deacetylase
P21437 yggF Fructose-1,6-bisphosphatase 2 class 2
P21599 pykA Pyruvate kinase II
P21829 ybhA Pyridoxal phosphate phosphatase YbhA
P23538 ppsA Phosphoenolpyruvate synthase
P33221 purT Formate-dependent phosphoribosylglycinamide formyltransferase
P37689 gpmI 2,3-bisphosphoglycerate-independent phosphoglycerate mutase
P39451 adhP Alcohol dehydrogenase, propanol-preferring
P42632 tdcE PFL-like enzyme TdcE
P45425 nanK N-acetylmannosamine kinase
P62707 gpmA 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase
P77218 eutD Phosphate acetyltransferase EutD
P77580 mhpF Acetaldehyde dehydrogenase
Q8XNZ3 nanE Putative N-acetylmannosamine-6-phosphate 2-epimerase
Q9S4K9 nanA N-acetylneuraminate lyase