superpathway of demethylmenaquinol-8 biosynthesis I
Heide L, Leistner E. Enzymatic synthesis of the coenzyme a ester of o-succinylbenzoic acid, an intermediate in menaquinone (vitamin K2) biosynthesis. FEBS Letters. 1981 Jun 15;128(2):201–4. doi: 10.1016/0014-5793(81)80080-4.
Metabolites
2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate
Formula: C14H13O9 (325.0559548)
CAS ID:
Enzyme
| EC Number | name | full name | note |
|---|---|---|---|
| 2.2.1.9 | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase | isochorismate:2-oxoglutarate 4-oxopentanoatetransferase (decarboxylating) | |
| 2.5.1.74 | 1,4-dihydroxy-2-naphthoate polyprenyltransferase | all-trans-polyprenyl diphosphate:1,4-dihydroxy-2-naphthoate polyprenyltransferase | |
| 2.5.1.90 | all-trans-octaprenyl-diphosphate synthase | (2E,6E)-farnesyl-diphosphate:isopentenyl-diphosphate farnesyltranstransferase (adding 5 isopentenyl units) | |
| 3.1.2.28 | 1,4-dihydroxy-2-naphthoyl-CoA hydrolase | 1,4-dihydroxy-2-naphthoyl-CoA hydrolase | |
| 4.1.3.36 | 1,4-dihydroxy-2-naphthoyl-CoA synthase | 4-(2-carboxyphenyl)-4-oxobutanoyl-CoA dehydratase (cyclizing) | |
| 4.2.1.113 | o-succinylbenzoate synthase | (1R,6R)-6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate hydrolyase (2-succinylbenzoate-forming) | |
| 4.2.99.20 | 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase | 5-enolpyruvoyl-6-hydroxy-2-succinylcyclohex-3-ene-1-carboxylate pyruvate-lyase [(1R,6R)-6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate-forming] | |
| 5.4.4.2 | isochorismate synthase | isochorismate hydroxymutase | |
| 6.2.1.26 | O-succinylbenzoate-CoA ligase | 2-succinylbenzoate:CoA ligase (AMP-forming) |
Proteins
| Protein ID | name | full name |
|---|---|---|
| P0ABU0 | menB | 1,4-dihydroxy-2-naphthoyl-CoA synthase |
| P0AD57 | ispB | Octaprenyl diphosphate synthase |
| P17109 | menD | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase |
| P29208 | menC | o-succinylbenzoate synthase |
| P32166 | menA | 1,4-dihydroxy-2-naphthoate octaprenyltransferase |
| P37353 | menE | 2-succinylbenzoate--CoA ligase |
| P37355 | menH | 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase |
| P38051 | menF | Isochorismate synthase MenF |
| P77781 | menI | 1,4-dihydroxy-2-naphthoyl-CoA hydrolase |
| Q838J9 | menD | 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylic acid synthase/2-oxoglutarate decarboxylase |
| Q838K1 | EF_0446 | O-succinylbenzoic acid--CoA ligase, putative |