superpathway of purine nucleotide salvage

Spychala J, Datta NS, Takabayashi K, Datta M, Fox IH, Gribbin T, Mitchell BS. Cloning of human adenosine kinase cDNA: sequence similarity to microbial ribokinases and fructokinases. Proc. Natl. Acad. Sci. U.S.A. 1996 Feb 06;93(3):1232–7. doi: 10.1073/pnas.93.3.1232.; Lewis AS, Lowy BA. Human erythrocyte purine nucleoside phosphorylase: molecular weight and physical properties. A Theorell-Chance catalytic mechanism. Journal of Biological Chemistry. 1979 Oct;254(19):9927–32. doi: 10.1016/s0021-9258(19)83606-2.

Metabolites

Adenine

Formula: C5H5N5 (135.054493)

CAS ID: 73-24-5

Adenosine

Formula: C10H13N5O4 (267.09674980000005)

CAS ID: 58-61-7

Diphosphate

Formula: H4P2O7 (177.9432294)

CAS ID: 2466-09-3

Guanine

Formula: C5H5N5O (151.049408)

CAS ID: 73-40-5

Guanosine

Formula: C10H13N5O5 (283.09166480000005)

CAS ID: 118-00-3

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Hypoxanthine

Formula: C5H4N4O (136.03850939999998)

CAS ID: 68-94-0

Inosine

Formula: C10H12N4O5 (268.08076619999997)

CAS ID: 58-63-9

Magnesium cation

Formula: Mg (23.98505)

CAS ID: 22537-22-0

(2R,3S)-3-(6-Amino-9H-purin-9-yl)nonan-2-ol

Formula: C14H23N5O (277.1902508)

CAS ID: 51350-19-7

butenedioate

Formula: C4H2O4 (113.99530920000001)

CAS ID: 17013-01-3

L-aspartate(1-)

Formula: C4H6NO4 (132.0296816)

CAS ID:

adenosine 5'-monophosphate(2-)

Formula: C10H12N5O7P (345.0474332)

CAS ID:

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

NADH(2-)

Formula: C21H27N7O14P2 (663.1091182000001)

CAS ID:

NAD(1-)

Formula: C21H26N7O14P2 (662.1012936000001)

CAS ID: 53-84-9

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:



Enzyme

EC Number name full name note
2.7.-.-
1.1.1.205 IMP dehydrogenase IMP:NAD+ oxidoreductase
1.17.4.1 ribonucleoside-diphosphate reductase 2'-deoxyribonucleoside-5'-diphosphate:thioredoxin-disulfide 2'-oxidoreductase
2.4.2.1 purine-nucleoside phosphorylase purine-nucleoside:phosphate ribosyltransferase
2.4.2.7 adenine phosphoribosyltransferase AMP:diphosphate phospho-D-ribosyltransferase
2.4.2.8 hypoxanthine phosphoribosyltransferase IMP:diphosphate phospho-D-ribosyltransferase
2.7.1.20 adenosine kinase ATP:adenosine 5'-phosphotransferase
2.7.13.3 histidine kinase ATP:protein-L-histidine N-phosphotransferase
2.7.4.10 nucleoside-triphosphate-adenylate kinase nucleoside-triphosphate:AMP phosphotransferase
2.7.4.3 adenylate kinase ATP:AMP phosphotransferase
2.7.4.4 nucleoside-phosphate kinase ATP:nucleoside-phosphate phosphotransferase
2.7.4.6 nucleoside-diphosphate kinase ATP:nucleoside-diphosphate phosphotransferase
2.7.4.8 guanylate kinase ATP:(d)GMP phosphotransferase
3.5.4.4 adenosine deaminase adenosine aminohydrolase
4.3.2.2 adenylosuccinate lyase N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming)
6.3.4.4 adenylosuccinate synthase IMP:L-aspartate ligase (GDP-forming)
6.3.5.2 GMP synthase (glutamine-hydrolysing) xanthosine-5'-phosphate:L-glutamine amido-ligase (AMP-forming)


Proteins

Protein ID name full name