superpathway of aromatic compound degradation via 2-hydroxypentadienoate
Marín M, Plumeier I, Pieper DH. Degradation of 2,3-dihydroxybenzoate by a novel meta-cleavage pathway. J Bacteriol. 2012 Aug;194(15):3851–60. PMID: 22609919; PMCID: PMC3416551.; Kasai D, Fujinami T, Abe T, Mase K, Katayama Y, Fukuda M, Masai E. Uncovering the protocatechuate 2,3-cleavage pathway genes. J Bacteriol. 2009 Nov;191(21):6758–68. PMID: 19717587; PMCID: PMC2795304.; Takenaka S, Sato T, Koshiya J, Murakami S, Aoki K. Gene cloning and characterization of a deaminase from the 4-amino-3-hydroxybenzoate-assimilating Bordetella sp. strain 10d. FEMS Microbiol Lett. 2009 Sep;298(1):93–8. doi: 10.1111/j.1574-6968.2009.01699.x. PMID: 19594622.; Harwood CS, Parales RE. The beta-ketoadipate pathway and the biology of self-identity. Annu Rev Microbiol. 1996;50():553–90. doi: 10.1146/annurev.micro.50.1.553. PMID: 8905091.; Kukor JJ, Olsen RH. Genetic organization and regulation of a meta cleavage pathway for catechols produced from catabolism of toluene, benzene, phenol, and cresols by Pseudomonas pickettii PKO1. J Bacteriol. 1991 Aug;173(15):4587–94. doi: 10.1128/jb.173.15.4587-4594.1991.; Menn FM, Zylstra GJ, Gibson DT. Location and sequence of the todF gene encoding 2-hydroxy-6-oxohepta-2,4-dienoate hydrolase in Pseudomonas putida F1. Gene. 1991 Jul 31;104(1):91–4. doi: 10.1016/0378-1119(91)90470-v. PMID: 1916282.; Kishore G, Sugumaran M, Vaidyanathan CS. Metabolism of DL-(+/-)-phenylalanine by Aspergillus niger. J Bacteriol. 1976 Oct;128(1):182–91. doi: 10.1128/jb.128.1.182-191.1976.; Wheelis ML, Stanier RY. The genetic control of dissimilatory pathways in Pseudomonas putida. Genetics. 1970 Oct;66(2):245–66. PMID: 5525301; PMCID: PMC1212492.
Metabolites
Enzyme
| EC Number | name | full name | note |
|---|---|---|---|
| 1.13.11.- | |||
| 1.1.5.8 | quinate/shikimate dehydrogenase (quinone) | quinate:quinol 3-oxidoreductase | |
| 1.1.99.31 | (S)-mandelate dehydrogenase | (S)-2-hydroxy-2-phenylacetate:acceptor 2-oxidoreductase | |
| 1.13.11.2 | catechol 2,3-dioxygenase | catechol:oxygen 2,3-oxidoreductase (decyclizing) | |
| 1.14.12.1 | anthranilate 1,2-dioxygenase (deaminating, decarboxylating) | anthranilate,NAD(P)H:oxygen oxidoreductase (1,2-hydroxylating, deaminating, decarboxylating) | |
| 1.14.12.12 | naphthalene 1,2-dioxygenase | naphthalene,NADH:oxygen oxidoreductase (1,2-hydroxylating) | |
| 1.14.13.1 | salicylate 1-monooxygenase | salicylate,NADH:oxygen oxidoreductase (1-hydroxylating, decarboxylating) | |
| 1.14.13.2 | 4-hydroxybenzoate 3-monooxygenase | 4-hydroxybenzoate,NADPH:oxygen oxidoreductase (3-hydroxylating) | |
| 1.18.1.3 | ferredoxin-NAD+ reductase | ferredoxin:NAD+ oxidoreductase | |
| 1.18.1.7 | ferredoxin-NAD(P)+ reductase (naphthalene dioxygenase ferredoxin-specific) | ferredoxin:NAD(P)+ oxidoreductase | |
| 1.2.1.28 | benzaldehyde dehydrogenase (NAD+) | benzaldehyde:NAD+ oxidoreductase | |
| 1.2.1.65 | salicylaldehyde dehydrogenase | salicylaldehyde:NAD+ oxidoreductase | |
| 1.2.1.7 | benzaldehyde dehydrogenase (NADP+) | benzaldehyde:NADP+ oxidoreductase | |
| 1.2.1.85 | 2-hydroxymuconate-6-semialdehyde dehydrogenase | 2-hydroxymuconate-6-semialdehyde:NAD+ oxidoreductase | |
| 1.3.1.25 | 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase | (1R,6S)-1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate:NAD+ oxidoreductase (decarboxylating) | |
| 3.7.1.25 | 2-hydroxy-6-oxohepta-2,4-dienoate hydrolase | (2Z,4E)-2-hydroxy-6-oxohepta-2,4-dienoate acetylhydrolase | |
| 3.7.1.3 | kynureninase | L-kynurenine hydrolase | |
| 3.7.1.9 | 2-hydroxymuconate-6-semialdehyde hydrolase | 2-hydroxymuconate-6-semialdehyde formylhydrolase | |
| 4.1.1.7 | benzoylformate decarboxylase | benzoylformate carboxy-lyase (benzaldehyde-forming) | |
| 4.1.1.77 | 2-oxo-3-hexenedioate decarboxylase | (3E)-2-oxohex-3-enedioate carboxy-lyase (2-oxopent-4-enoate-forming) | |
| 4.1.2.45 | trans-o-hydroxybenzylidenepyruvate hydratase-aldolase | (3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate hydro-lyase | |
| 4.1.3.39 | 4-hydroxy-2-oxovalerate aldolase | 4-hydroxy-2-oxopentanoate pyruvate-lyase (acetaldehyde-forming) | |
| 4.2.1.10 | 3-dehydroquinate dehydratase | 3-dehydroquinate hydro-lyase (3-dehydroshikimate-forming) | |
| 4.2.1.118 | 3-dehydroshikimate dehydratase | 3-dehydroshikimate hydro-lyase | |
| 5.1.2.2 | mandelate racemase | mandelate racemase | |
| 5.3.2.6 | 2-hydroxymuconate tautomerase | (2Z,4E)-2-hydroxyhexa-2,4-dienedioate keto-enol isomerase | |
| 5.99.1.4 | 2-hydroxychromene-2-carboxylate isomerase | 2-hydroxy-2H-chromene-2-carboxylate-(3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate isomerase |
Proteins
| Protein ID | name | full name |
|---|---|---|
| A5W4E9 | todA | Toluene 1,2-dioxygenase system ferredoxin--NAD(+) reductase component |
| O85673 | antA | Anthranilate 1,2-dioxygenase large subunit |
| O85674 | antB | Anthranilate 1,2-dioxygenase small subunit |
| O85675 | antC | Anthranilate 1,2-dioxygenase electron transfer component |
| P00438 | pobA | p-hydroxybenzoate hydroxylase |
| P06622 | xylE | Metapyrocatechase |
| P0A110 | ndoB | Naphthalene 1,2-dioxygenase system, large oxygenase component |
| P0A144 | nahE | Trans-O-hydroxybenzylidenepyruvate hydratase-aldolase |
| P0A391 | nahF | Salicylaldehyde dehydrogenase |
| P11444 | mdlA | Mandelate racemase |
| P13453 | todE | 3-methylcatechol 2,3-dioxygenase |
| P13859 | todD | Cis-toluene dihydrodiol dehydrogenase |
| P20906 | mdlC | Benzoylformate decarboxylase |
| P20932 | mdlB | (S)-mandelate dehydrogenase |
| P23099 | xylX | Toluate 1,2-dioxygenase subunit alpha |
| P23100 | xylY | Toluate 1,2-dioxygenase subunit beta |
| P23101 | xylZ | Toluate 1,2-dioxygenase electron transfer component |
| P23102 | xylL | 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase |
| P23105 | xylG | 2-hydroxymuconic semialdehyde dehydrogenase |
| P23106 | xylF | 2-hydroxymuconate semialdehyde hydrolase |
| P23107 | xylJ | 2-hydroxypent-2,4-dienoate hydratase |
| P23133 | todF | 2-hydroxy-6-oxo-2,4-heptadienoate hydrolase |
| P23262 | nahG | Salicylate hydroxylase |
| P43503 | xylC | Benzaldehyde dehydrogenase [NAD(+)] |
| P49155 | xylI | 4-oxalocrotonate decarboxylase |
| P51018 | todH | 4-hydroxy-2-oxovalerate aldolase 1 |
| P51019 | xylK | 4-hydroxy-2-oxovalerate aldolase |
| P83788 | kynU | Kynureninase |
| Q01468 | xylH | 2-hydroxymuconate tautomerase |
| Q43922 | quiC | 3-dehydroshikimate dehydratase |
| Q51948 | nahD | 2-hydroxychromene-2-carboxylate isomerase |
| Q52126 | ndoR | Naphthalene 1,2-dioxygenase system ferredoxin--NAD(P)(+), reductase component |
| Q59086 | quiA | Quinate/shikimate dehydrogenase (quinone) |
| Q59087 | quiB | Catabolic 3-dehydroquinate dehydratase |
| Q84DC3 | mdlD | NAD(P)-dependent benzaldehyde dehydrogenase |