superpathway of phenylalanine, tyrosine and tryptophan biosynthesis

Rippert P, Matringe M. Purification and kinetic analysis of the two recombinant arogenate dehydrogenase isoforms of Arabidopsis thaliana. European Journal of Biochemistry. 2002 Sep 18;269(19):4753–61. doi: 10.1046/j.1432-1033.2002.03172.x.; Entus R, Poling M, Herrmann KM. Redox regulation of Arabidopsis 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase. Plant Physiol. 2002 Aug;129(4):1866–71. PMID: 12177500; PMCID: PMC166775.; Radwanski ER, Last RL. Tryptophan biosynthesis and metabolism: biochemical and molecular genetics. Plant Cell. 1995 Jul;7(7):921–34. PMID: 7640526; PMCID: PMC160888.; Siehl DL, Conn EE. Kinetic and regulatory properties of arogenate dehydratase in seedlings of Sorghum bicolor (L.) moench. Archives of Biochemistry and Biophysics. 1988 Feb;260(2):822–9. doi: 10.1016/0003-9861(88)90513-9.; Klee HJ, Muskopf YM, Gasser CS. Cloning of an Arabidopsis thaliana gene encoding 5-enolpyruvylshikimate-3-phosphate synthase: sequence analysis and manipulation to obtain glyphosate-tolerant plants. Molecular Genetics and Genomics. 1987 Dec;210(3):437–42. doi: 10.1007/bf00327194.

Metabolites

CO2

Formula: CO2 (43.98983)

CAS ID: 124-38-9

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Indole

Formula: C8H7N (117.0578462)

CAS ID: 120-72-9

2-oxoglutarate(2-)

Formula: C5H4O5 (144.00587339999998)

CAS ID: 64-15-3

pyruvate

Formula: C3H3O3 (87.00821880000001)

CAS ID: 57-60-3

anthranilate

Formula: C7H6NO2 (136.0398516)

CAS ID: 9031-59-8

NADPH(4-)

Formula: C21H26N7O17P3 (741.0598016)

CAS ID: 53-57-6

NADP(3-)

Formula: C21H25N7O17P3 (740.051977)

CAS ID: 53-59-8

pyridoxal 5'-phosphate(2-)

Formula: C8H8NO6P (245.0089238)

CAS ID:



Enzyme

EC Number name full name note
1.3.1.78 arogenate dehydrogenase (NADP+) L-arogenate:NADP+ oxidoreductase (decarboxylating)
2.4.2.18 anthranilate phosphoribosyltransferase N-(5-phospho-D-ribosyl)-anthranilate:diphosphate phospho-alpha-D-ribosyltransferase
2.6.1.1 aspartate transaminase L-aspartate:2-oxoglutarate aminotransferase
2.6.1.78 aspartate-prephenate aminotransferase L-arogenate:oxaloacetate aminotransferase
2.6.1.79 glutamate-prephenate aminotransferase L-arogenate:2-oxoglutarate aminotransferase
4.1.1.48 indole-3-glycerol-phosphate synthase 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate carboxy-lyase [cyclizing; 1-C-(indol-3-yl)glycerol-3-phosphate-forming]
4.1.2.8 indole-3-glycerol-phosphate lyase (1S,2R)-1-C-(indol-3-yl)glycerol-3-phosphate D-glyceraldehyde-3-phosphate-lyase (indole-forming)
4.1.3.27 anthranilate synthase chorismate pyruvate-lyase (amino-accepting; anthranilate-forming)
4.2.1.20 tryptophan synthase L-serine hydro-lyase [adding 1-C-(indol-3-yl)glycerol 3-phosphate; L-tryptophan and glyceraldehyde-3-phosphate-forming]
4.2.1.51 prephenate dehydratase prephenate hydro-lyase (decarboxylating; phenylpyruvate-forming)
4.2.1.91 arogenate dehydratase L-arogenate hydro-lyase (decarboxylating; L-phenylalanine-forming)
5.3.1.24 phosphoribosylanthranilate isomerase N-(5-phospho-beta-D-ribosyl)anthranilate aldose-ketose-isomerase
5.4.99.5 chorismate mutase Chorismate pyruvatemutase


Proteins

Protein ID name full name