Pyruvate Metabolism

Metabolites

(R)-Lactate

Formula: C3H6O3 (90.0316926)

CAS ID: 10326-41-7

(S)-Lactaldehyde

Formula: C3H6O2 (74.0367776)

CAS ID: 3913-64-2

(S)-Lactate

Formula: C3H6O3 (90.0316926)

CAS ID: 79-33-4

(S)-Malate

Formula: C4H6O5 (134.0215226)

CAS ID: 97-67-6

3-Methyl-2-oxobutanoic acid

Formula: C5H8O3 (116.0473418)

CAS ID: 759-05-7

Acetaldehyde

Formula: C2H4O (44.0262134)

CAS ID: 75-07-0

Acetate

Formula: C2H4O2 (60.0211284)

CAS ID: 64-19-7

Acetyl adenylate

Formula: C12H16N5O8P (389.0736466)

CAS ID: 13015-87-7

Acetyl-CoA

Formula: C23H38N7O17P3S (809.1257688000001)

CAS ID: 72-89-9

ADP

Formula: C10H15N5O10P2 (427.02941500000003)

CAS ID: 58-64-0

alpha-Isopropylmalate

Formula: C7H12O5 (176.06847019999998)

CAS ID: 49601-06-1

AMP

Formula: C10H14N5O7P (347.06308240000004)

CAS ID: 61-19-8

ATP

Formula: C10H16N5O13P3 (506.9957476)

CAS ID: 56-65-5

CO2

Formula: CO2 (43.98983)

CAS ID: 124-38-9

Ethanol

Formula: C2H6O (46.0418626)

CAS ID: 64-17-5

Glutathione

Formula: C10H17N3O6S (307.08380220000004)

CAS ID: 70-18-8

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

HCO3-

Formula: HCO3 (60.9925696)

CAS ID: 71-52-3

Methylglyoxal

Formula: C3H4O2 (72.0211284)

CAS ID: 78-98-8

NAD+

Formula: C21H28N7O14P2 (664.1169428000001)

CAS ID: 53-84-9

NADH

Formula: C21H29N7O14P2 (665.1247674)

CAS ID: 58-68-4

NADP+

Formula: C21H29N7O17P3 (744.0832754)

CAS ID: 53-59-8

Oxaloacetate

Formula: C4H4O5 (132.00587339999998)

CAS ID: 328-42-7

Phosphoenolpyruvate

Formula: C3H5O6P (167.98237600000002)

CAS ID: 138-08-9

Pyruvate

Formula: C3H4O3 (88.0160434)

CAS ID: 127-17-3

diphosphate

Formula: O7P2 (173.911931)

CAS ID: 14000-31-8

phosphate(3-)

Formula: O4P (94.953423)

CAS ID: 14265-44-2



Enzyme

EC Number name full name note
1.6.-.-
1.1.1.2 alcohol dehydrogenase (NADP+) alcohol:NADP+ oxidoreductase
1.1.1.265 3-methylbutanal reductase 3-methylbutanol:NAD(P)+ oxidoreductase
1.1.1.283 methylglyoxal reductase (NADPH) (S)-lactaldehyde:NADP+ oxidoreductase
1.1.1.38 malate dehydrogenase (oxaloacetate-decarboxylating) (S)-malate:NAD+ oxidoreductase (oxaloacetate-decarboxylating)
1.1.2.4 D-lactate dehydrogenase (cytochrome) (R)-lactate:ferricytochrome-c 2-oxidoreductase
1.1.99.40 (R)-2-hydroxyglutarate-pyruvate transhydrogenase (R)-2-hydroxyglutarate:pyruvate oxidoreductase [(R)-lactate-forming]
1.2.4.1 pyruvate dehydrogenase (acetyl-transferring) pyruvate:[dihydrolipoyllysine-residue acetyltransferase]-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-acetylating)
1.8.1.7 glutathione-disulfide reductase glutathione:NADP+ oxidoreductase
2.3.1.9 acetyl-CoA C-acetyltransferase acetyl-CoA:acetyl-CoA C-acetyltransferase
2.3.3.13 2-isopropylmalate synthase acetyl-CoA:3-methyl-2-oxobutanoate C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming)
2.3.3.14 homocitrate synthase acetyl-CoA:2-oxoglutarate C-acetyltransferase (thioester-hydrolysing, carboxymethyl forming)
2.7.1.40 pyruvate kinase ATP:pyruvate 2-O-phosphotransferase
3.1.2.1 acetyl-CoA hydrolase acetyl-CoA hydrolase
3.1.2.6 hydroxyacylglutathione hydrolase S-(2-hydroxyacyl)glutathione hydrolase
4.1.1.43 phenylpyruvate decarboxylase phenylpyruvate carboxy-lyase (phenylacetaldehyde-forming)
4.1.1.49 phosphoenolpyruvate carboxykinase (ATP) ATP:oxaloacetate carboxy-lyase (transphosphorylating; phosphoenolpyruvate-forming)
4.1.1.72 branched-chain-2-oxoacid decarboxylase (3S)-3-methyl-2-oxopentanoate carboxy-lyase (2-methylbutanal-forming)
4.1.1.74 indolepyruvate decarboxylase 3-(indol-3-yl)pyruvate carboxy-lyase [(2-indol-3-yl)acetaldehyde-forming]
4.4.1.5 lactoylglutathione lyase (R)-S-lactoylglutathione methylglyoxal-lyase (isomerizing; glutathione-forming)
6.2.1.1 acetate-CoA ligase acetate:CoA ligase (AMP-forming)
6.3.4.14 biotin carboxylase [biotin carboxyl-carrier protein]-biotin-N6-L-lysine:hydrogencarbonate ligase (ADP-forming)
6.4.1.1 pyruvate carboxylase pyruvate:carbon-dioxide ligase (ADP-forming)
6.4.1.2 acetyl-CoA carboxylase acetyl-CoA:hydrogencarbonate ligase (ADP-forming)


Proteins

Protein ID name full name
P00549 CDC19 Pyruvate kinase 1
P06169 PDC1 Pyruvate decarboxylase isozyme 1
P06208 LEU4 2-isopropylmalate synthase
P10963 PCK1 Phosphoenolpyruvate carboxykinase (ATP)
P11154 PYC1 Pyruvate carboxylase 1
P16467 PDC5 Pyruvate decarboxylase isozyme 2
P25377 ADH7 NADP-dependent alcohol dehydrogenase 7
P26263 PDC6 Pyruvate decarboxylase isozyme 3
P32316 ACH1 Acetyl-CoA hydrolase
P32327 PYC2 Pyruvate carboxylase 2
P32473 PDB1 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
P32891 DLD1 D-lactate dehydrogenase [cytochrome] 1, mitochondrial
P36013 MAE1 NAD-dependent malic enzyme, mitochondrial
P39976 DLD3 D-2-hydroxyglutarate--pyruvate transhydrogenase DLD3
P41338 ERG10 Acetyl-CoA acetyltransferase
P41921 GLR1 Glutathione reductase
P46681 DLD2 D-2-hydroxyglutarate--pyruvate transhydrogenase DLD2
P50107 GLO1 Glyoxalase I
P52489 PYK2 Pyruvate kinase 2
P52910 ACS2 Acetyl-coenzyme A synthetase 2
Q00955 ACC1 Acetyl-CoA carboxylase
Q01574 ACS1 Acetyl-coenzyme A synthetase 1
Q04894 ADH6 NADP-dependent alcohol dehydrogenase 6
Q05584 GLO2 Hydroxyacylglutathione hydrolase, cytoplasmic isozyme
Q12068 GRE2 NADPH-dependent methylglyoxal reductase GRE2
Q12122 LYS21 Homocitrate synthase, mitochondrial
Q12166 LEU9 2-isopropylmalate synthase 2, mitochondrial
Q12320 GLO4 Hydroxyacylglutathione hydrolase, mitochondrial