(R)-Lactate (BioCAD00000000869)

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Metabolite Card

Formula: C3H6O3 (90.0317)
SMILES: C[C@@H](O)C(O)=O

Synonyms [en]

D-Lactic acid; Lactic Acid; (R)-lactate; D-2-Hydroxypropionic acid; D-Milchsaeure; (R)-Lactic acid

Reviewed

Last reviewed on 2024-06-28.

Cite this Page

(R)-Lactate. 数据之源，洞见之始. SMRUCC genomics institute, a synthetic life researcher from China. https://biocad_registry.innovation.ac.cn/s/(-)-arctiin (retrieved 2026-01-03) (CAD Registry RN: BioCAD00000000869). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

Note

Lactic acid is an organic acid. It is a chiral molecule, consisting of two optical isomers, L-lactic acid and D-lactic acid, with the L-isomer being the most common in living organisms. Lactic acid plays a role in several biochemical processes and is produced in the muscles during intense activity. D-Lactic acid is the end product of the enzyme glyoxalase II (or hydroxyacyl-glutathione hydrolase) (EC 3.1.2.6), which converts the intermediate substrate S-lactoyl-glutathione to reduced glutathione and D-lactate (OMIM: 138790). Lactic acid is a microbial metabolite found in Aerococcus, Bacillus, Carnobacterium, Corynebacterium, Enterococcus, Escherichia, Lactobacillus, Lactococcus, Leuconostoc, Oenococcus, Pediococcus, Rhizopus, Saccharomyces, Streptococcus, Tetragenococcus, Vagococcus and Weissella (PMID:26287368; PMID:26360870).

Extracellular Mitochondria
Entity Information

DBLinks

Other DBLinks
  • CAS Registry Number: 10326-41-7
  • PubChem: 61503
  • ChEBI: ChEBI:16004
  • ChEBI: ChEBI:42111
  • HMDB: HMDB0001311
  • HMDB: HMDB01311
  • LipidMaps: LMFA01050002
  • KEGG: C00256
  • NCBI MeSH: Lactic Acid
  • Wikipedia: Lactic_acid
  • DrugBank: DB03066
  • DrugBank: DB04398
  • RefMet: RM0136088
  • MoNA: HMDB0001311_c_ms_102652
  • MoNA: HMDB0001311_c_ms_102653
  • MoNA: HMDB0001311_c_ms_102654
  • MoNA: HMDB0001311_ms_ms_1513
  • MoNA: HMDB0001311_ms_ms_1514
  • MoNA: HMDB0001311_ms_ms_1515
  • MoNA: MT000003
  • MoNA: PS068507
  • Metlin: METLIN_63094
  • Coconut NaturalProduct: CNP0232038.2

Class / Ontology

Metabolic Network
ID EC Number Name
KEGG:R00197 1.1.2.4 (R)-lactate:ferricytochrome-c 2-oxidoreductase
KEGG:R00198 1.1.2.5 (R)-lactate:ferricytochrome-c-553 2-oxidoreductase
KEGG:R00297 1.1.99.6 (R)-2-hydroxy-acid:acceptor 2-oxidoreductase
KEGG:R00704 1.1.1.28 (R)-lactate:NAD+ oxidoreductase
KEGG:R01448 3.1.6.17 (R)-2-O-sulfolactate 2-sulfohydrolase
KEGG:R01450 5.1.2.1 lactate racemase
KEGG:R01735 1.2.1.23 (R)-lactaldehyde:NAD+ 2-oxidoreductase
KEGG:R01736 3.1.2.6 (R)-S-lactoylglutathione hydrolase
KEGG:R08555 4.2.1.126 (R)-lactate hydro-lyase (adding N-acetyl-D-glucosamine 6-phosphate; N-acetylmuramate 6-phosphate-forming)
KEGG:R09588 6.1.2.1 D-alanine:(R)-lactate ligase (ADP-forming)
KEGG:R09796 4.2.1.130 (R)-lactate hydro-lyase
KEGG:R11591 1.1.5.12 (R)-lactate:quinone 2-oxidoreductase
KEGG:R11593 1.1.99.40 (R)-2-hydroxyglutarate:pyruvate oxidoreductase [(R)-lactate-forming]
KEGG:R13049 1.1.1.436 (R)-lactate:NAD+,ferredoxin oxidoreductase
Rhea:RHEA:10961 5.1.2.1 (S)-lactate => (R)-lactate
Rhea:RHEA:10962 5.1.2.1 (R)-lactate => (S)-lactate
Rhea:RHEA:10963 5.1.2.1 (S)-lactate <=> (R)-lactate
Rhea:RHEA:13522 1.1.2.4 (R)-lactate + 2 Fe(III)-[cytochrome c] => 2 Fe(II)-[cytochrome c] + pyruvate + 2 H+
Rhea:RHEA:13523 1.1.2.4 2 Fe(II)-[cytochrome c] + pyruvate + 2 H+ => (R)-lactate + 2 Fe(III)-[cytochrome c]
Rhea:RHEA:13524 1.1.2.4 (R)-lactate + 2 Fe(III)-[cytochrome c] <=> 2 Fe(II)-[cytochrome c] + pyruvate + 2 H+
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Organism Source

Taxonomy Source

  1. Aloe africana [ncbi taxid: 1080010]
  2. Aloe ferox [ncbi taxid: 117798]
  3. Aloe microstigma [ncbi taxid: 1128801]
  4. Aloe spicata [ncbi taxid: 992642]
  5. Aloe vera [ncbi taxid: 34199]
  6. Aplidium multiplicatum [ncbi taxid: 3106037]
  7. Artemisia tridentata [ncbi taxid: 55611]
  8. Bipolaris victoriae [ncbi taxid: 40125]
  9. Chrozophora prostrata [ncbi taxid: ]
  10. Clausena heptaphylla [ncbi taxid: 1392232]
  11. Dendrobates leucomelas [ncbi taxid: 85590]
  12. Escherichia coli [ncbi taxid: 562]
  13. Homo sapiens [ncbi taxid: 9606]
  14. Hypsizigus marmoreus [ncbi taxid: ]
  15. Lepraria flava [ncbi taxid: ]
  16. Leptothorax muscorum [ncbi taxid: 61281]
  17. Papaver somniferum [ncbi taxid: 3469]
  18. Penicillium gilmanii [ncbi taxid: ]
  19. Prunus mume [ncbi taxid: 102107]
  20. Pseudocyphellaria nitida [ncbi taxid: ]
  21. Saccharomyces cerevisiae [ncbi taxid: 4932]
  22. Sarcomelicope glauca [ncbi taxid: ]
  23. Senegalia caffra [ncbi taxid: 875631]
  24. Stemona japonica [ncbi taxid: 85282]
  25. Stereum princeps [ncbi taxid: ]
  26. Taraxacum rubicundum [ncbi taxid: 90050]
  27. Tecoma grandis [ncbi taxid: ]

Pathway Synthetic

pathway id name
PathBank:SMP0000905 Amino Sugar and Nucleotide Sugar Metabolism I
PathBank:SMP0000906 Amino Sugar and Nucleotide Sugar Metabolism II
PathBank:SMP0000914 Amino Sugar and Nucleotide Sugar Metabolism III
PathBank:SMP0002076 1,6-Anhydro-N-acetylmuramic Acid Recycling
PathBank:SMP0002096 Methylglyoxal Degradation II
WikiPathways:WP4584 Biomarkers for pyrimidine metabolism disorders
WikiPathways:WP3604 Biochemical pathways: part I
PathBank:SMP0120726 Leigh Syndrome
PathBank:SMP0120842 Pyruvate Kinase Deficiency
PathBank:SMP0122240 1,6-Anhydro-N-acetylmuramic Acid Recycling
PathBank:SMP0000334 Pyruvate Decarboxylase E1 Component Deficiency (PDHE1 Deficiency)
PathBank:SMP0087386 Pyruvaldehyde Degradation
PathBank:SMP0087394 Pyruvate Metabolism
PathBank:SMP0063661 Pyruvate Metabolism
PathBank:SMP0120753 Pyruvate Decarboxylase E1 Component Deficiency (PDHE1 Deficiency)
PathBank:SMP0120841 Primary Hyperoxaluria II, PH2
PathBank:SMP0120531 Pyruvate Dehydrogenase Complex Deficiency
PathBank:SMP0121303 Amino Sugar and Nucleotide Sugar Metabolism III
PathBank:SMP0000459 Pyruvaldehyde Degradation
PathBank:SMP0000196 Leigh Syndrome
View All Pathways