Lysine Biosynthesis

Metabolites

2-Oxoglutarate

Formula: C5H6O5 (146.0215226)

CAS ID: 328-50-7

ADP

Formula: C10H15N5O10P2 (427.02941500000003)

CAS ID: 58-64-0

ATP

Formula: C10H16N5O13P3 (506.9957476)

CAS ID: 56-65-5

CO2

Formula: CO2 (43.98983)

CAS ID: 124-38-9

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

L-Glutamate

Formula: C5H9NO4 (147.0531554)

CAS ID: 56-86-0

L-Lysine

Formula: C6H14N2O2 (146.1055224)

CAS ID: 56-87-1

NADP+

Formula: C21H29N7O17P3 (744.0832754)

CAS ID: 53-59-8

Pyruvate

Formula: C3H4O3 (88.0160434)

CAS ID: 127-17-3

phosphate(3-)

Formula: O4P (94.953423)

CAS ID: 14265-44-2



Enzyme

EC Number name full name note
1.17.1.8 4-hydroxy-tetrahydrodipicolinate reductase (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate:NAD(P)+ 4-oxidoreductase
1.2.1.11 aspartate-semialdehyde dehydrogenase L-aspartate-4-semialdehyde:NADP+ oxidoreductase (phosphorylating)
2.3.1.117 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase succinyl-CoA:(S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase
2.6.1.11 acetylornithine transaminase N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase
2.6.1.17 succinyldiaminopimelate transaminase N-succinyl-L-2,6-diaminoheptanedioate:2-oxoglutarate aminotransferase
2.7.2.4 aspartate kinase ATP:L-aspartate 4-phosphotransferase
3.5.1.18 succinyl-diaminopimelate desuccinylase N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase
4.1.1.20 diaminopimelate decarboxylase meso-2,6-diaminoheptanedioate carboxy-lyase (L-lysine-forming)
4.3.3.7 4-hydroxy-tetrahydrodipicolinate synthase L-aspartate-4-semialdehyde hydro-lyase [adding pyruvate and cyclizing; (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinate-forming]
5.1.1.7 diaminopimelate epimerase LL-2,6-diaminoheptanedioate 2-epimerase
7.4.2.1 ABC-type polar-amino-acid transporter ATP phosphohydrolase (ABC-type, polar-amino-acid-importing)


Proteins

Protein ID name full name
P00861 lysA Diaminopimelate decarboxylase
P04036 dapB 4-hydroxy-tetrahydrodipicolinate reductase
P08660 lysC Lysine-sensitive aspartokinase 3
P0A6K1 dapF Diaminopimelate epimerase
P0A6L2 dapA 4-hydroxy-tetrahydrodipicolinate synthase
P0A9D8 dapD 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase
P0A9Q9 asd Aspartate-semialdehyde dehydrogenase
P0AAG3 gltL Glutamate/aspartate import ATP-binding protein GltL
P0AED7 dapE Succinyl-diaminopimelate desuccinylase
P18335 argD Acetylornithine/succinyldiaminopimelate aminotransferase