Cysteine and methionine catabolism

Bandarian V, Pattridge KA, Lennon BW, Huddler DP, Matthews RG, Ludwig ML. Domain alternation switches B12-dependent methionine synthase to the activation conformation. Nature Structural & Molecular Biology. 2001 Dec 03;9(1):53–6. doi: 10.1038/nsb738.

Metabolites

Adenosine

Formula: C10H13N5O4 (267.09674980000005)

CAS ID: 58-61-7

Betaine

Formula: C5H11NO2 (117.0789746)

CAS ID: 107-43-7

CO2

Formula: CO2 (43.98983)

CAS ID: 124-38-9

Cystine

Formula: C6H12N2O4S2 (240.02384719999998)

CAS ID: 923-32-0

Glutamine

Formula: C5H10N2O3 (146.069139)

CAS ID: 6899-04-3

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Hydrogen sulfide

Formula: H2S (33.9877212)

CAS ID: 7783-06-4

Oxygen

Formula: O2 (31.98983)

CAS ID: 7782-44-7

S-Sulfo-L-cysteine

Formula: C3H7NO5S2 (200.97656519999998)

CAS ID: 1637-71-4

Sulfate

Formula: H2SO4 (97.9673812)

CAS ID: 7664-93-9

Taurine

Formula: C2H7NO3S (125.0146632)

CAS ID: 107-35-7

2-oxoglutarate(2-)

Formula: C5H4O5 (144.00587339999998)

CAS ID: 64-15-3

pyruvate

Formula: C3H3O3 (87.00821880000001)

CAS ID: 57-60-3

sulfite

Formula: O3S (79.956817)

CAS ID: 14265-45-3

thiosulfate(2-)

Formula: O3S2 (111.928889)

CAS ID: 14383-50-7

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

hydrosulfide

Formula: HS (32.979896600000004)

CAS ID: 15035-72-0



Enzyme

EC Number name full name note
1.13.11.18 persulfide dioxygenase S-sulfanylglutathione:oxygen oxidoreductase
1.13.11.20 cysteine dioxygenase L-cysteine:oxygen oxidoreductase
1.8.5.8 eukaryotic sulfide quinone oxidoreductase sulfide:glutathione,quinone oxidoreductase
2.1.1.13 methionine synthase 5-methyltetrahydrofolate:L-homocysteine S-methyltransferase
2.1.1.5 betaine-homocysteine S-methyltransferase trimethylammonioacetate:L-homocysteine S-methyltransferase
2.6.1.1 aspartate transaminase L-aspartate:2-oxoglutarate aminotransferase
2.6.1.3 cysteine transaminase L-cysteine:2-oxoglutarate aminotransferase
2.8.1.2 3-mercaptopyruvate sulfurtransferase 3-mercaptopyruvate:cyanide sulfurtransferase
3.13.2.1 adenosylhomocysteinase S-adenosyl-L-homocysteine hydrolase
4.1.1.11 aspartate 1-decarboxylase L-aspartate 1-carboxy-lyase (beta-alanine-forming)
4.1.1.29 sulfinoalanine decarboxylase 3-sulfino-L-alanine carboxy-lyase (hypotaurine-forming)
4.2.1.22 cystathionine beta-synthase L-serine hydro-lyase (adding homocysteine; L-cystathionine-forming)
4.4.1.1 cystathionine gamma-lyase L-cystathionine cysteine-lyase (deaminating; 2-oxobutanoate-forming)
4.4.1.2 homocysteine desulfhydrase L-homocysteine hydrogen-sulfide-lyase (deaminating; 2-oxobutanoate-forming)
6.3.2.3 glutathione synthase gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)


Proteins

Protein ID name full name