Glycerophospholipid biosynthesis

Orsó E, Grandl M, Schmitz G. Oxidized LDL-induced endolysosomal phospholipidosis and enzymatically modified LDL-induced foam cell formation determine specific lipid species modulation in human macrophages. Chem Phys Lipids. 2011 Sep;164(6):479–87. doi: 10.1016/j.chemphyslip.2011.06.001. PMID: 21683693.; Scherer M, Schmitz G. Metabolism, function and mass spectrometric analysis of bis(monoacylglycero)phosphate and cardiolipin. Chem Phys Lipids. 2011 Sep;164(6):556–62. doi: 10.1016/j.chemphyslip.2011.06.007. PMID: 21704024.; Hermansson M, Hokynar K, Somerharju P. Mechanisms of glycerophospholipid homeostasis in mammalian cells. Prog Lipid Res. 2011 Jul;50(3):240–57. doi: 10.1016/j.plipres.2011.02.004. PMID: 21382416.; Osman C, Voelker DR, Langer T. Making heads or tails of phospholipids in mitochondria. J Cell Biol. 2011 Jan 10;192(1):7–16. PMID: 21220505; PMCID: PMC3019561.; Lev S. Non-vesicular lipid transport by lipid-transfer proteins and beyond. Nature Reviews Molecular Cell Biology. 2010 Sep 08;11(10):739–50. doi: 10.1038/nrm2971.; Lebiedzinska M, Szabadkai G, Jones AWE, Duszynski J, Wieckowski MR. Interactions between the endoplasmic reticulum, mitochondria, plasma membrane and other subcellular organelles. The International Journal of Biochemistry & Cell Biology. 2009 Oct;41(10):1805–16. doi: 10.1016/j.biocel.2009.02.017.

Metabolites

Acetaldehyde

Formula: C2H4O (44.0262134)

CAS ID: 75-07-0

Acetylcholine

Formula: C7H16NO2 (146.1180976)

CAS ID: 51-84-3

Ammonia

Formula: NH3 (17.0265478)

CAS ID: 7664-41-7

Calcium cation

Formula: Ca (39.962591)

CAS ID: 14127-61-8

CDP-choline

Formula: C14H26N4O11P2 (488.10732659999996)

CAS ID: 987-78-0

Choline

Formula: C5H14NO (104.10753340000001)

CAS ID: 62-49-7

Ethanolamine phosphate

Formula: C2H8NO4P (141.0190938)

CAS ID: 1071-23-4

Glycerol

Formula: C3H8O3 (92.0473418)

CAS ID: 56-81-5

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Magnesium cation

Formula: Mg (23.98505)

CAS ID: 22537-22-0

Sodium cation

Formula: Na (22.98977)

CAS ID: 17341-25-2

Zinc cation

Formula: Zn (63.929145)

CAS ID: 23713-49-7

Glycerophosphocholine

Formula: C8H20NO6P (257.102819)

CAS ID: 28319-77-9

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

NAD(1-)

Formula: C21H26N7O14P2 (662.1012936000001)

CAS ID: 53-84-9

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:



Enzyme

EC Number name full name note
2.7.8.2 diacylglycerol cholinephosphotransferase CDP-choline:1,2-diacyl-sn-glycerol cholinephosphotransferase
3.1.1.4 phospholipase A2 phosphatidylcholine 2-acylhydrolase
3.1.1.5 lysophospholipase 2-lysophosphatidylcholine acylhydrolase


Proteins

Protein ID name full name