Signaling by GPCR

Oldham WM, Hamm HE. Heterotrimeric G protein activation by G-protein-coupled receptors. Nature Reviews Molecular Cell Biology. 2008 Jan;9(1):60–71. doi: 10.1038/nrm2299.; Jacoby E, Bouhelal R, Gerspacher M, Seuwen K. The 7 TM G-protein-coupled receptor target family. ChemMedChem. 2006 Aug;1(8):761–82. doi: 10.1002/cmdc.200600134. PMID: 16902930.; Bockaert J, Pin JP. Molecular tinkering of G protein-coupled receptors: an evolutionary success. EMBO J. 1999 Apr 01;18(7):1723–9. PMID: 10202136; PMCID: PMC1171258.

Metabolites

2-Arachidonoylglycerol

Formula: C23H38O4 (378.2769948)

CAS ID: 53847-30-6

Acetylcholine

Formula: C7H16NO2 (146.1180976)

CAS ID: 51-84-3

Adenosine

Formula: C10H13N5O4 (267.09674980000005)

CAS ID: 58-61-7

Calcium cation

Formula: Ca (39.962591)

CAS ID: 14127-61-8

Glycerol

Formula: C3H8O3 (92.0473418)

CAS ID: 56-81-5

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Magnesium cation

Formula: Mg (23.98505)

CAS ID: 22537-22-0

Melatonin

Formula: C13H16N2O2 (232.1211716)

CAS ID: 73-31-4

N-Arachidonoylglycine

Formula: C22H35NO3 (361.26168000000007)

CAS ID: 179113-91-8

lysophosphatidic acid

Formula: C21H41O7P (436.25897660000004)

CAS ID:

adenosine 5'-monophosphate(2-)

Formula: C10H12N5O7P (345.0474332)

CAS ID:

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

GTP(4-)

Formula: C10H12N5O14P3 (518.9593642)

CAS ID: 86527-72-2

UDP(3-)

Formula: C9H11N2O12P2 (400.9787246)

CAS ID: 86527-70-0

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:

3',5'-cyclic AMP(1-)

Formula: C10H11N5O6P (328.0446936)

CAS ID: 62906-31-4

histaminium

Formula: C5H10N3 (112.087468)

CAS ID: 65592-96-3

dopaminium(1+)

Formula: C8H12NO2 (154.0867992)

CAS ID:

serotonin(1+)

Formula: C10H13N2O (177.1027828)

CAS ID:



Enzyme

EC Number name full name note
2.7.1.137 phosphatidylinositol 3-kinase ATP:1-phosphatidyl-1D-myo-inositol 3-phosphotransferase
2.7.10.2 non-specific protein-tyrosine kinase ATP:[protein]-L-tyrosine O-phosphotransferase (non-specific)
2.7.11.11 cAMP-dependent protein kinase ATP:protein Ser/Thr-phosphotransferase (3',5'-cAMP-dependent)
2.7.11.13 protein kinase C ATP:protein phosphotransferase (diacylglycerol-dependent)
2.7.11.16 G-protein-coupled receptor kinase ATP:[G-protein-coupled receptor] phosphotransferase
2.7.11.17 Ca2+/calmodulin-dependent protein kinase ATP:protein phosphotransferase (Ca2+/calmodulin-dependent)
2.7.11.24 mitogen-activated protein kinase ATP:protein phosphotransferase (MAPKK-activated)
3.1.4.11 phosphoinositide phospholipase C 1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase
3.1.4.17 3',5'-cyclic-nucleotide phosphodiesterase 3',5'-cyclic-nucleotide 5'-nucleotidohydrolase
3.1.4.53 3',5'-cyclic-AMP phosphodiesterase 3',5'-cyclic-AMP 5'-nucleotidohydrolase
3.6.5.2 small monomeric GTPase GTP phosphohydrolase (cell-regulating)


Proteins

Protein ID name full name