EC: 3.5.4.12

dCMP deaminase (dCMP aminohydrolase)

enzyme lambda metabolic reaction experiment
uniprot:P32321 [2'-beta-D-deoxyribose pyrimidin-2-one 5'-phosphate]

dCMP + H2O -> NH3 + dUMP		 (( (( (E * kcat) ) * S) ) / (( (Km * (1 + (I / Ki))) ) + S)) buffer: 10 mM Tris-HCl, 1 mM MgCl2, 5 mM mercaptoethanol
PH: 8
Temperature: 30
uniprot:P32321 [dCTP]

dCMP + H2O -> NH3 + dUMP		 (( (( (E * kcat) ) * (S ^ n)) ) / (( (S_h ^ n) ) + (S ^ n))) buffer: 10 mM Tris-HCl, 1 mM MgCl2, 5 mM mercaptoethanol
PH: 8
Temperature: 30
uniprot:P32321 [dCTP]

H2O + dCMP -> dUMP + NH3		 (( (( (E * kcat) ) * (S ^ n)) ) / (( (S_h ^ n) ) + (S ^ n))) buffer: 10 mM Tris-HCl, 1 mM MgCl2, 5 mM mercaptoethanol
PH: 8
Temperature: 30

Pathways

pathway id name
BioCyc:HUMAN_PWY-7210 pyrimidine deoxyribonucleotides biosynthesis from CTP
BioCyc:META_PWY-7210 pyrimidine deoxyribonucleotides biosynthesis from CTP
BioCyc:YEAST_PWY-7210 pyrimidine deoxyribonucleotides biosynthesis from CTP
Reactome:R-MMU-1430728 Metabolism
Reactome:R-SPO-1430728 Metabolism
Reactome:R-SPO-15869 Nucleotide metabolism
Reactome:R-SPO-499943 Interconversion of nucleotide di- and triphosphates
Reactome:R-DME-1430728 Metabolism
Reactome:R-SCE-1430728 Metabolism
Reactome:R-CEL-15869 Nucleotide metabolism
Reactome:R-CEL-499943 Interconversion of nucleotide di- and triphosphates
Reactome:R-DME-15869 Nucleotide metabolism
Reactome:R-DME-499943 Interconversion of nucleotide di- and triphosphates
Reactome:R-RNO-1430728 Metabolism
Reactome:R-SCE-15869 Nucleotide metabolism
Reactome:R-SCE-499943 Interconversion of nucleotide di- and triphosphates
Reactome:R-CEL-1430728 Metabolism
Reactome:R-HSA-1430728 Metabolism
Reactome:R-HSA-15869 Nucleotide metabolism
Reactome:R-HSA-499943 Interconversion of nucleotide di- and triphosphates
Reactome:R-MMU-15869 Nucleotide metabolism
Reactome:R-MMU-499943 Interconversion of nucleotide di- and triphosphates
Reactome:R-RNO-15869 Nucleotide metabolism
Reactome:R-RNO-499943 Interconversion of nucleotide di- and triphosphates
PathBank:SMP0120678 beta-Ureidopropionase Deficiency
PathBank:SMP0120750 MNGIE (Mitochondrial Neurogastrointestinal Encephalopathy)
PathBank:SMP0000178 Dihydropyrimidinase Deficiency
PathBank:SMP0120693 Dihydropyrimidinase Deficiency
PathBank:SMP0000046 Pyrimidine Metabolism
PathBank:SMP0000219 UMP Synthase Deficiency (Orotic Aciduria)
PathBank:SMP0000446 Gemcitabine Action Pathway
PathBank:SMP0087473 Pyrimidine Metabolism
PathBank:SMP0000202 MNGIE (Mitochondrial Neurogastrointestinal Encephalopathy)
PathBank:SMP0087340 Pyrimidine Metabolism
PathBank:SMP0120727 UMP Synthase Deficiency (Orotic Aciduria)
PathBank:SMP0000172 beta-Ureidopropionase Deficiency
PathBank:SMP0000603 Gemcitabine Metabolism Pathway