Signaling by GPCR

Oldham WM, Hamm HE. Heterotrimeric G protein activation by G-protein-coupled receptors. Nature Reviews Molecular Cell Biology. 2008 Jan;9(1):60–71. doi: 10.1038/nrm2299.; Jacoby E, Bouhelal R, Gerspacher M, Seuwen K. The 7 TM G-protein-coupled receptor target family. ChemMedChem. 2006 Aug;1(8):761–82. doi: 10.1002/cmdc.200600134. PMID: 16902930.; Bockaert J, Pin JP. Molecular tinkering of G protein-coupled receptors: an evolutionary success. EMBO J. 1999 Apr 01;18(7):1723–9. PMID: 10202136; PMCID: PMC1171258.

Metabolites

(S)-Lactate

Formula: C3H6O3 (90.0316926)

CAS ID: 79-33-4

2-Arachidonoylglycerol

Formula: C23H38O4 (378.2769948)

CAS ID: 53847-30-6

Acetylcholine

Formula: C7H16NO2 (146.1180976)

CAS ID: 51-84-3

Adenosine

Formula: C10H13N5O4 (267.09674980000005)

CAS ID: 58-61-7

Calcium cation

Formula: Ca (39.962591)

CAS ID: 14127-61-8

Cholest-5-ene-3beta,7alpha,25-triol

Formula: C27H46O3 (418.34467659999996)

CAS ID: 64907-22-8

Fe2+

Formula: Fe (55.934939)

CAS ID: 15438-31-0

Glycerol

Formula: C3H8O3 (92.0473418)

CAS ID: 56-81-5

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Magnesium cation

Formula: Mg (23.98505)

CAS ID: 22537-22-0

Manganese(2+)

Formula: Mn (54.938046)

CAS ID: 7439-96-5

Melatonin

Formula: C13H16N2O2 (232.1211716)

CAS ID: 73-31-4

Phenethylamine

Formula: C8H11N (121.0891446)

CAS ID: 64-04-0

Zinc cation

Formula: Zn (63.929145)

CAS ID: 23713-49-7

N-Arachidonoylglycine

Formula: C22H35NO3 (361.26168000000007)

CAS ID: 179113-91-8

PC O-18:0/2:0

Formula: C28H58NO7P (551.3950688)

CAS ID: 74389-69-8

lysophosphatidic acid

Formula: C21H41O7P (436.25897660000004)

CAS ID:

2-oxoglutarate(2-)

Formula: C5H4O5 (144.00587339999998)

CAS ID: 64-15-3

succinate(2-)

Formula: C4H4O4 (116.01095839999999)

CAS ID: 56-14-4

prostaglandin I2(1-)

Formula: C20H31O5 (351.2171376)

CAS ID:

prostaglandin F2alpha(1-)

Formula: C20H33O5 (353.23278680000004)

CAS ID:

adenosine 5'-monophosphate(2-)

Formula: C10H12N5O7P (345.0474332)

CAS ID:

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

GTP(4-)

Formula: C10H12N5O14P3 (518.9593642)

CAS ID: 86527-72-2

UDP-alpha-D-glucose(2-)

Formula: C15H22N2O17P2 (564.0393702)

CAS ID:

UDP(3-)

Formula: C9H11N2O12P2 (400.9787246)

CAS ID: 86527-70-0

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:

3',5'-cyclic AMP(1-)

Formula: C10H11N5O6P (328.0446936)

CAS ID: 62906-31-4

histaminium

Formula: C5H10N3 (112.087468)

CAS ID: 65592-96-3

dopaminium(1+)

Formula: C8H12NO2 (154.0867992)

CAS ID:

serotonin(1+)

Formula: C10H13N2O (177.1027828)

CAS ID:



Enzyme

EC Number name full name note
2.7.1.137 phosphatidylinositol 3-kinase ATP:1-phosphatidyl-1D-myo-inositol 3-phosphotransferase
2.7.1.153 phosphatidylinositol-4,5-bisphosphate 3-kinase ATP:1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate 3-phosphotransferase
2.7.11.1 non-specific serine/threonine protein kinase ATP:protein phosphotransferase (non-specific)
2.7.11.11 cAMP-dependent protein kinase ATP:protein Ser/Thr-phosphotransferase (3',5'-cAMP-dependent)
2.7.11.15 beta-adrenergic-receptor kinase ATP:[beta-adrenergic receptor] phosphotransferase
2.7.11.24 mitogen-activated protein kinase ATP:protein phosphotransferase (MAPKK-activated)
3.1.1.4 phospholipase A2 phosphatidylcholine 2-acylhydrolase
3.1.1.5 lysophospholipase 2-lysophosphatidylcholine acylhydrolase
3.1.3.16 protein-serine/threonine phosphatase protein-serine/threonine-phosphate phosphohydrolase
3.1.4.17 3',5'-cyclic-nucleotide phosphodiesterase 3',5'-cyclic-nucleotide 5'-nucleotidohydrolase
3.4.24.71 endothelin-converting enzyme 1
3.6.5.2 small monomeric GTPase GTP phosphohydrolase (cell-regulating)


Proteins

Protein ID name full name