APAP ADME

Esh CJ, Chrismas BCR, Mauger AR, Taylor L. Pharmacological hypotheses: Is acetaminophen selective in its cyclooxygenase inhibition? Pharmacol Res Perspect. 2021 Aug;9(4):e00835. PMID: 34278737; PMCID: PMC8287062.; Graham GG, Davies MJ, Day RO, Mohamudally A, Scott KF. The modern pharmacology of paracetamol: therapeutic actions, mechanism of action, metabolism, toxicity and recent pharmacological findings. Inflammopharmacology. 2013 Jun;21(3):201–32. doi: 10.1007/s10787-013-0172-x. PMID: 23719833.; McGill MR, Jaeschke H. Metabolism and Disposition of Acetaminophen: Recent Advances in Relation to Hepatotoxicity and Diagnosis. Pharmaceutical Research. 2013 Mar 06;30(9):2174–87. doi: 10.1007/s11095-013-1007-6.; Forrest JA, Clements JA, Prescott LF. Clinical pharmacokinetics of paracetamol. Clin Pharmacokinet. 1982 Mar;7(2):93–107. doi: 10.2165/00003088-198207020-00001. PMID: 7039926.

Metabolites

Acetaminophen

Formula: C8H9NO2 (151.0633254)

CAS ID: 103-90-2

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Isoniazid

Formula: C6H7N3O (137.0589092)

CAS ID: 54-85-3

Manganese(2+)

Formula: Mn (54.938046)

CAS ID: 7439-96-5

Oxygen

Formula: O2 (31.98983)

CAS ID: 7782-44-7

Zinc cation

Formula: Zn (63.929145)

CAS ID: 23713-49-7

Paracetamol sulfate

Formula: C8H9NO5S (231.0201424)

CAS ID: 10066-90-7

acetate

Formula: C2H3O2 (59.0133038)

CAS ID: 71-50-1

NADPH(4-)

Formula: C21H26N7O17P3 (741.0598016)

CAS ID: 53-57-6

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

UDP(3-)

Formula: C9H11N2O12P2 (400.9787246)

CAS ID: 86527-70-0

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:

NADP(3-)

Formula: C21H25N7O17P3 (740.051977)

CAS ID: 53-59-8



Enzyme

EC Number name full name note
1.14.13.n7
1.14.14.1 unspecific monooxygenase substrate,NADPH-hemoprotein reductase:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
2.3.2.2 gamma-glutamyltransferase (5-L-glutamyl)-peptide:amino-acid 5-glutamyltransferase
2.5.1.18 glutathione transferase RX:glutathione R-transferase
2.8.2.1 aryl sulfotransferase 3'-phosphoadenylyl-sulfate:phenol sulfotransferase
2.8.2.14 bile-salt sulfotransferase 3'-phosphoadenylyl-sulfate:glycolithocholate sulfotransferase
2.8.2.2 alcohol sulfotransferase 3'-phosphoadenylyl-sulfate:alcohol sulfotransferase
2.8.2.4 estrone sulfotransferase 3'-phosphoadenylyl-sulfate:estrone 3-sulfotransferase
3.4.13.18 cytosol nonspecific dipeptidase
3.4.19.13 glutathione gamma-glutamate hydrolase
3.4.19.14 leukotriene-C4 hydrolase
3.5.1.14 N-acyl-aliphatic-L-amino acid amidohydrolase N-acyl-aliphatic-L-amino acid amidohydrolase (carboxylate-forming)


Proteins

Protein ID name full name