3-hydroxypropanoate/4-hydroxybutanate cycle
Berg IA, Kockelkorn D, Buckel W, Fuchs G. A 3-hydroxypropionate/4-hydroxybutyrate autotrophic carbon dioxide assimilation pathway in Archaea. Science. 2007 Dec 14;318(5857):1782–6. doi: 10.1126/science.1149976. PMID: 18079405.; Zhu X, Lapthorn AJ, Ellis EM. Crystal structure of mouse succinic semialdehyde reductase AKR7A5: structural basis for substrate specificity. Biochemistry. 2006 Feb 14;45(6):1562–70. doi: 10.1021/bi051610k. PMID: 16460003.; Murakami H, Sly WS. Purification and characterization of human salivary carbonic anhydrase. Journal of Biological Chemistry. 1987 Jan;262(3):1382–8. doi: 10.1016/s0021-9258(19)75797-4.
Metabolites
Enzyme
| EC Number | name | full name | note |
|---|---|---|---|
| 1.2.1.75 | malonyl-CoA reductase (malonate semialdehyde-forming) | malonate semialdehyde:NADP+ oxidoreductase (malonate semialdehyde-forming) | |
| 1.2.1.76 | succinate-semialdehyde dehydrogenase (acylating) | succinate semialdehyde:NADP+ oxidoreductase (CoA-acylating) | |
| 1.3.1.84 | acrylyl-CoA reductase (NADPH) | propanoyl-CoA:NADP+ oxidoreductase | |
| 4.2.1.116 | 3-hydroxypropionyl-CoA dehydratase | 3-hydroxypropionyl-CoA hydro-lyase | |
| 6.2.1.1 | acetate-CoA ligase | acetate:CoA ligase (AMP-forming) | |
| 6.2.1.17 | propionate-CoA ligase | propanoate:CoA ligase (AMP-forming) | |
| 6.2.1.2 | medium-chain acyl-CoA ligase | medium-chain fatty acid:CoA ligase (AMP-forming) | |
| 6.2.1.36 | 3-hydroxypropionyl-CoA synthase | 3-hydroxypropionate:CoA ligase (AMP-forming) | |
| 6.2.1.40 | 4-hydroxybutyrate-CoA ligase (AMP-forming) | 4-hydroxybutyrate:CoA ligase (AMP formimg) |
Proteins
| Protein ID | name | full name |
|---|---|---|
| A4YDT1 | Msed_0406 | AMP-dependent synthetase and ligase |
| A4YEN2 | Msed_0709 | succinyl-CoA reductase (NADPH) |
| A4YGN0 | Msed_1424 | succinate semialdehyde reductase (NADPH) |
| A4YGR1 | Msed_1456 | 3-hydroxypropionyl-CoA synthetase |
| A4YI89 | Msed_2001 | short chain enoyl-CoA hydratase |
| Q96YK1 | mcr | Malonyl-CoA reductase |
| Q975C8 | ACAR_SULTO | Acryloyl-coenzyme A reductase |