Acitretin (BioCAD00000026113)

blood urine

Metabolite Card

Formula: C21H26O3 (326.1882)
SMILES: COC1=C(C)C(C)=C(\C=C\C(\C)=C\C=C\C(\C)=C\C(O)=O)C(C)=C1

Synonyms [en]

Acitretin; (2E,4E,6E,8E)-9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethylnona-2,4,6,8-tetraenoic acid; Etretin; Neotigason; (all-E)-9-(4-Methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-2,4,6,8-nonatetraenoic acid; all-trans-3,7-Dimethyl-9-(4-methoxy-2,3,6-trimethylphenyl)-2,4,6,8-nonatetraenoic acid

Reviewed

Last reviewed on 2024-06-28.

Cite this Page

Acitretin. 数据之源，洞见之始. SMRUCC genomics institute, a synthetic life researcher from China. https://biocad_registry.innovation.ac.cn/s/(-)-arctiin (retrieved 2026-01-03) (CAD Registry RN: BioCAD00000026113). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

Note

Acitretin is only found in individuals that have used or taken this drug. It is an oral retinoid effective in the treatment of psoriasis. It is the major metabolite of etretinate with the advantage of a much shorter half-life when compared with etretinate (PubChem). The mechanism of action of acitretin is unknown, however it is believed to work by targeting specific receptors (retinoid receptors such as RXR and RAR) in the skin which help normalize the growth cycle of skin cells.

Cytoplasm Extracellular Membrane
Entity Information

DBLinks

Other DBLinks
  • CAS Registry Number: 419534-31-9
  • CAS Registry Number: 54757-46-9
  • CAS Registry Number: 55079-83-9
  • CAS Registry Number: 925701-88-8 (sodium salt)
  • PubChem: 5284513
  • ChEBI: ChEBI:50172
  • ChEBI: ChEBI:50173
  • HMDB: HMDB0014602
  • HMDB: HMDB14602
  • KEGG: C75579
  • KEGG: D02754
  • NCBI MeSH: Acitretin
  • Wikipedia: Acitretin
  • DrugBank: DB00459
  • RefMet: RM0200589
  • MoNA: CCMSLIB00000077146
  • MoNA: CCMSLIB00000078116
  • MoNA: HMDB0014602_ms_ms_1218148
  • MoNA: HMDB0014602_ms_ms_1218149
  • Metlin: METLIN_564

Class / Ontology

Metabolic Network
ID EC Number Name
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Organism Source

Taxonomy Source

Pathway Synthetic

pathway id name
Reactome:R-CFA-162582 Signaling Pathways
Reactome:R-CFA-5362517 Signaling by Retinoic Acid
Reactome:R-DME-9006931 Signaling by Nuclear Receptors
Reactome:R-GGA-5362517 Signaling by Retinoic Acid
Reactome:R-HSA-5362517 Signaling by Retinoic Acid
Reactome:R-MMU-162582 Signaling Pathways
Reactome:R-RNO-162582 Signaling Pathways
Reactome:R-RNO-9006931 Signaling by Nuclear Receptors
Reactome:R-BTA-162582 Signaling Pathways
Reactome:R-CFA-9006931 Signaling by Nuclear Receptors
Reactome:R-DRE-162582 Signaling Pathways
Reactome:R-DRE-5362517 Signaling by Retinoic Acid
Reactome:R-DME-162582 Signaling Pathways
Reactome:R-GGA-9006931 Signaling by Nuclear Receptors
Reactome:R-HSA-9006931 Signaling by Nuclear Receptors
Reactome:R-SSC-5362517 Signaling by Retinoic Acid
Reactome:R-BTA-9006931 Signaling by Nuclear Receptors
Reactome:R-DME-5362517 Signaling by Retinoic Acid
Reactome:R-MMU-9006931 Signaling by Nuclear Receptors
Reactome:R-RNO-5362517 Signaling by Retinoic Acid
View All Pathways