Rhea:RHEA:47846
Published in: "Biosynthesis of Thiamin I: The Function of the thiE Gene Product." Backstrom AD, McMordie RAS, Begley TP J Am Chem Soc 117: 2351-2352 (1995).
thiamine phosphate + CO2 + diphosphate => 2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H+
= thiamine(1+) monophosphate(2-)[C12H16N4O4PS] + CO2[CO2] + diphosphate(3-)[HO7P2] + (R,Z)- 2-carboxylato-4-methyl-5-[(2-phosphonatooxy)ethylidene]-2,5-dihydrothiazole(3-)[C7H7NO6PS] + 4-amino-2-methyl-5-diphosphomethylpyrimidine[C6H8N3O7P2] + H+[H]
DB Links
- EC Number: 2.5.1.3
- Rhea: RHEA:47846
Alias
- [Rhea:RHEA:47845] 2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H+ => thiamine phosphate + CO2 + diphosphate
- [Rhea:RHEA:47846] thiamine phosphate + CO2 + diphosphate => 2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H+
- [Rhea:RHEA:47847] 2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H+ <=> thiamine phosphate + CO2 + diphosphate
Metabolites
Substrates
| metabolite | compartment | Structure |
|---|
Products
| metabolite | compartment | Structure |
|---|---|---|
| thiamine(1+) monophosphate(2-) Formula: C12H16N4O4PS |
Cytoplasm | |
| CO2 Formula: CO2 |
Cytoplasm | |
| diphosphate(3-) Formula: HO7P2 |
Cytoplasm | |
| (R,Z)- 2-carboxylato-4-methyl-5-[(2-phosphonatooxy)ethylidene]-2,5-dihydrothiazole(3-) Formula: C7H7NO6PS |
Cytoplasm | |
| 4-amino-2-methyl-5-diphosphomethylpyrimidine Formula: C6H8N3O7P2 |
Cytoplasm | |
| H+ Formula: H |
Cytoplasm |