Rhea:RHEA:32460
Multi-step reaction: RHEA:19089 and RHEA:21972
uroporphyrinogen III + 2 S-adenosyl-L-methionine => precorrin-2 + 2 S-adenosyl-L-homocysteine + H+
= uroporphyrinogen III(8-)[C40H36N4O16] + S-adenosyl-L-methionine zwitterion[C15H23N6O5S] + precorrin-2(7-)[C42H41N4O16] + S-adenosyl-L-homocysteine zwitterion[C14H20N6O5S] + H+[H]
DB Links
- BioCyc: RXN-13403
- EC Number: 2.1.1.107
- Rhea: RHEA:32460
Alias
- [Rhea:RHEA:32460] uroporphyrinogen III + 2 S-adenosyl-L-methionine => precorrin-2 + 2 S-adenosyl-L-homocysteine + H+
- [Rhea:RHEA:32461] precorrin-2 + 2 S-adenosyl-L-homocysteine + H+ => uroporphyrinogen III + 2 S-adenosyl-L-methionine
- [Rhea:RHEA:32462] uroporphyrinogen III + 2 S-adenosyl-L-methionine <=> precorrin-2 + 2 S-adenosyl-L-homocysteine + H+
Metabolites
Substrates
| metabolite | compartment | Structure |
|---|
Products
| metabolite | compartment | Structure |
|---|---|---|
| uroporphyrinogen III(8-) Formula: C40H36N4O16 |
Cytoplasm | |
| S-adenosyl-L-methionine zwitterion Formula: C15H23N6O5S |
Cytoplasm | |
| precorrin-2(7-) Formula: C42H41N4O16 |
Cytoplasm | |
| S-adenosyl-L-homocysteine zwitterion Formula: C14H20N6O5S |
Cytoplasm | |
| H+ Formula: H |
Cytoplasm |