Pathways Knowlegdes

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Pathway DOIs Note
S-methyl-5-thio-α-D-ribose 1-phosphate degradation

Accession ID: BioCyc:HUMAN_PWY-4361		 -
L-methionine salvage cycle III

Accession ID: BioCyc:META_PWY-7527
  • 10.1002/iub.278
  • 10.1016/j.resmic.2011.01.001
  • 10.1016/s0021-9258(18)34705-7
  • 10.1042/bj20121744
 Sauter M, Moffatt B, Saechao MC, Hell R, Wirtz M. Methionine salvage and S-adenosylmethionine: essential links between sulfur, ethylene and polyamine biosynthesis. Biochem J. 2013 Apr 15;451(2):145–54. doi: 10.1042/bj20121744. PMID: 23535167.; Cobzaru C, Ganas P, Mihasan M, Schleberger P, Brandsch R. Homologous gene clusters of nicotine catabolism, including a new ?-amidase for a-ketoglutaramate, in species of three genera of Gram-positive bacteria. Res Microbiol. 2011 Apr;162(3):285–91. doi: 10.1016/j.resmic.2011.01.001. PMID: 21288482.; Albers E. Metabolic characteristics and importance of the universal methionine salvage pathway recycling methionine from 5'-methylthioadenosine. IUBMB Life. 2009 Dec;61(12):1132–42. doi: 10.1002/iub.278. PMID: 19946895.; Backlund PS, Chang CP, Smith RA. Identification of 2-keto-4-methylthiobutyrate as an intermediate compound in methionine synthesis from 5'-methylthioadenosine. Journal of Biological Chemistry. 1982 Apr;257(8):4196–202. doi: 10.1016/s0021-9258(18)34705-7.
methionine degradation III

Accession ID: BioCyc:PCHR_PWY-5082		 -
L-homomethionine biosynthesis

Accession ID: BioCyc:META_PWY-1186
  • 10.1016/s1360-1385(02)02273-2
  • 10.1104/pp.010416
 Wittstock U, Halkier BA. Glucosinolate research in the Arabidopsis era. Trends Plant Sci. 2002 Jun;7(6):263–70. doi: 10.1016/s1360-1385(02)02273-2. PMID: 12049923.; Kroymann J, Textor S, Tokuhisa JG, Falk KL, Bartram S, Gershenzon J, Mitchell-Olds T. A gene controlling variation in Arabidopsis glucosinolate composition is part of the methionine chain elongation pathway. Plant Physiol. 2001 Nov;127(3):1077–88. PMID: 11706188; PMCID: PMC129277.
L-methionine salvage cycle I (bacteria and plants)

Accession ID: BioCyc:META_PWY-7528
  • 10.1002/iub.278
  • 10.1016/j.resmic.2011.01.001
 Cobzaru C, Ganas P, Mihasan M, Schleberger P, Brandsch R. Homologous gene clusters of nicotine catabolism, including a new ?-amidase for a-ketoglutaramate, in species of three genera of Gram-positive bacteria. Res Microbiol. 2011 Apr;162(3):285–91. doi: 10.1016/j.resmic.2011.01.001. PMID: 21288482.; Albers E. Metabolic characteristics and importance of the universal methionine salvage pathway recycling methionine from 5'-methylthioadenosine. IUBMB Life. 2009 Dec;61(12):1132–42. doi: 10.1002/iub.278. PMID: 19946895.
L-methionine salvage cycle II (plants)

Accession ID: BioCyc:META_PWY-7270
  • 10.1002/iub.278
  • 10.1016/j.resmic.2011.01.001
  • 10.1111/j.1365-313x.2010.04211.x
 Cobzaru C, Ganas P, Mihasan M, Schleberger P, Brandsch R. Homologous gene clusters of nicotine catabolism, including a new ?-amidase for a-ketoglutaramate, in species of three genera of Gram-positive bacteria. Res Microbiol. 2011 Apr;162(3):285–91. doi: 10.1016/j.resmic.2011.01.001. PMID: 21288482.; Bürstenbinder K, Waduwara I, Schoor S, Moffatt BA, Wirtz M, Minocha SC, Oppermann Y, Bouchereau A, Hell R, Sauter M. Inhibition of 5'-methylthioadenosine metabolism in the Yang cycle alters polyamine levels, and impairs seedling growth and reproduction in Arabidopsis. Plant J. 2010 Jun 01;62(6):977–88. doi: 10.1111/j.1365-313x.2010.04211.x. PMID: 20345605.; Albers E. Metabolic characteristics and importance of the universal methionine salvage pathway recycling methionine from 5'-methylthioadenosine. IUBMB Life. 2009 Dec;61(12):1132–42. doi: 10.1002/iub.278. PMID: 19946895.
L-methionine degradation III

Accession ID: BioCyc:YEAST_PWY-5082		 -
ethylene biosynthesis

Accession ID: BioCyc:YEAST_PWY-6854		 -
methionine salvage cycle III

Accession ID: BioCyc:HUMAN_PWY-7527		 -
S-methyl-5'-thioadenosine degradation I

Accession ID: BioCyc:META_PWY-6754		 -
S-methyl-5-thio-α-D-ribose 1-phosphate degradation I

Accession ID: BioCyc:META_PWY-4361
  • 10.1002/iub.278
  • 10.1016/j.resmic.2011.01.001
 Cobzaru C, Ganas P, Mihasan M, Schleberger P, Brandsch R. Homologous gene clusters of nicotine catabolism, including a new ?-amidase for a-ketoglutaramate, in species of three genera of Gram-positive bacteria. Res Microbiol. 2011 Apr;162(3):285–91. doi: 10.1016/j.resmic.2011.01.001. PMID: 21288482.; Albers E. Metabolic characteristics and importance of the universal methionine salvage pathway recycling methionine from 5'-methylthioadenosine. IUBMB Life. 2009 Dec;61(12):1132–42. doi: 10.1002/iub.278. PMID: 19946895.
ethylene biosynthesis III (microbes)

Accession ID: BioCyc:META_PWY-6854
  • 10.1016/0378-1097(89)90086-4
 Fukuda H, Takahashi M, Fujii T, Tazaki M, Ogawa T. An NADH:Fe(III)EDTA oxidoreductase from Cryptococcus albidus: an enzyme involved in ethylene production in vivo? FEMS Microbiol Lett. 1989 Jul 01;51(1):107–11. doi: 10.1111/j.1574-6968.1989.tb03428.x. PMID: 2792734.
methionine salvage pathway

Accession ID: BioCyc:LEISH_PWY3IU-1026
  • 10.1016/j.molbiopara.2006.11.013
 Reguera RM, Redondo CM, Pérez-Pertejo Y, Balaña-Fouce R. S-Adenosylmethionine in protozoan parasites: Functions, synthesis and regulation. Molecular and Biochemical Parasitology. 2007 Mar;152(1):1–10. doi: 10.1016/j.molbiopara.2006.11.013.
S-methyl-5-thio-α-D-ribose 1-phosphate degradation

Accession ID: BioCyc:SYNEL_PWY-4361		 -
methionine degradation III

Accession ID: BioCyc:THAPS_PWY-5082		 -
S-methyl-5-thio-α-D-ribose 1-phosphate degradation

Accession ID: BioCyc:THAPS_PWY-6755		 -
dimethylsulfoniopropanoate biosynthesis III (algae)

Accession ID: BioCyc:META_PWY-6053
  • 10.1038/43160
 Gage DA, Rhodes D, Nolte KD, Hicks WA, Leustek T, Cooper AJ, Hanson AD. A new route for synthesis of dimethylsulphoniopropionate in marine algae. Nature. 1997 Jun 26;387(6636):891–4. doi: 10.1038/43160. PMID: 9202120.
L-methionine degradation III

Accession ID: BioCyc:META_PWY-5082
  • 10.1128/aem.71.6.3276-3284.2005
 Vuralhan Z, Luttik MAH, Tai SL, Boer VM, Morais MA, Schipper D, Almering MJH, Ko¨tter P, Dickinson JR, Daran J, Pronk JT. Physiological Characterization of the ARO10 -Dependent, Broad-Substrate-Specificity 2-Oxo Acid Decarboxylase Activity of Saccharomyces cerevisiae. Appl Environ Microbiol. 2005 Jun;71(6):3276–84. doi: 10.1128/aem.71.6.3276-3284.2005.
methionine salvage pathway

Accession ID: BioCyc:YEAST_PWY3O-64
  • 10.1111/j.1742-4658.2008.06552.x
  • 10.1128/.61.4.503-532.1997
 Pirkov I, Norbeck J, Gustafsson L, Albers E. A complete inventory of all enzymes in the eukaryotic methionine salvage pathway. FEBS J. 2008 Aug;275(16):4111–20. doi: 10.1111/j.1742-4658.2008.06552.x. PMID: 18625006.; Thomas D, Surdin-Kerjan Y. Metabolism of sulfur amino acids in Saccharomyces cerevisiae. Microbiol Mol Biol Rev. 1997 Dec;61(4):503–32. doi: 10.1128/mmbr.61.4.503-532.1997.
L-homomethionine biosynthesis

Accession ID: BioCyc:ARA_PWY-1186
  • 10.1016/s1360-1385(02)02273-2
  • 10.1104/pp.010416
  • 10.1105/tpc.105.039339
 Schuster J, Knill T, Reichelt M, Gershenzon J, Binder S. Branched-chain aminotransferase4 is part of the chain elongation pathway in the biosynthesis of methionine-derived glucosinolates in Arabidopsis. Plant Cell. 2006 Oct;18(10):2664–79. PMID: 17056707; PMCID: PMC1626624.; Wittstock U, Halkier BA. Glucosinolate research in the Arabidopsis era. Trends Plant Sci. 2002 Jun;7(6):263–70. doi: 10.1016/s1360-1385(02)02273-2. PMID: 12049923.; Kroymann J, Textor S, Tokuhisa JG, Falk KL, Bartram S, Gershenzon J, Mitchell-Olds T. A gene controlling variation in Arabidopsis glucosinolate composition is part of the methionine chain elongation pathway. Plant Physiol. 2001 Nov;127(3):1077–88. PMID: 11706188; PMCID: PMC129277.