Pathways Knowlegdes

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Pathway DOIs Note
superpathway of cholesterol biosynthesis

Accession ID: BioCyc:HUMAN_PWY66-5		 -
cholesterol biosynthesis II (via 24,25-dihydrolanosterol)

Accession ID: BioCyc:HUMAN_PWY66-3		 -
cholesterol biosynthesis II (via 24,25-dihydrolanosterol)

Accession ID: BioCyc:META_PWY66-3
  • 10.1006/bbrc.2001.2008
  • 10.1016/s0021-9258(19)50353-2
  • 10.1016/s0022-2275(20)38566-7
  • 10.1016/s0022-2275(20)41987-x
  • 10.1016/s0022-3565(25)24394-4
  • 10.1021/bi00030a003
  • 10.1042/bj3260609
  • 10.1074/jbc.m600395200
 Megha, Bakht O, London E. Cholesterol precursors stabilize ordinary and ceramide-rich ordered lipid domains (lipid rafts) to different degrees. Implications for the Bloch hypothesis and sterol biosynthesis disorders. J Biol Chem. 2006 Aug 04;281(31):21903–13. doi: 10.1074/jbc.m600395200. PMID: 16735517.; Gaylor JL. Membrane-Bound Enzymes of Cholesterol Synthesis from Lanosterol. Biochemical and Biophysical Research Communications. 2002 Apr;292(5):1139–46. doi: 10.1006/bbrc.2001.2008.; Bae SH, Paik YK. Cholesterol biosynthesis from lanosterol: development of a novel assay method and characterization of rat liver microsomal lanosterol delta 24-reductase. Biochem J. 1997 Sep 01;326 ( Pt 2)():609–16. PMID: 9291139; PMCID: PMC1218712.; Trzaskos JM, Ko SS, Magolda RL, Favata MF, Fischer RT, Stam SH, Johnson PR, Gaylor JL. Substrate-based inhibitors of lanosterol 14 alpha-methyl demethylase: I. Assessment of inhibitor structure-activity relationship and cholesterol biosynthesis inhibition properties. Biochemistry. 1995 Aug 01;34(30):9670–6. doi: 10.1021/bi00030a003. PMID: 7626636.; Buttke TM, Folks TM. Complete replacement of membrane cholesterol with 4,4',14-trimethyl sterols in a human T cell line defective in lanosterol demethylation. Journal of Biological Chemistry. 1992 May;267(13):8819–26. doi: 10.1016/s0021-9258(19)50353-2.; Tuck S, Patel H, Safi E, Robinson C. Lanosterol 14 alpha-demethylase (P45014DM): effects of P45014DM inhibitors on sterol biosynthesis downstream of lanosterol. Journal of Lipid Research. 1991 Jun;32(6):893–902. doi: 10.1016/s0022-2275(20)41987-x.; Miettinen TA. Cholesterol metabolism during ketoconazole treatment in man. Journal of Lipid Research. 1988 Jan;29(1):43–51. doi: 10.1016/s0022-2275(20)38566-7.; Kraemer FB, Spilman SD. Effects of ketoconazole on cholesterol synthesis. The Journal of Pharmacology and Experimental Therapeutics. 1986 Sep;238(3):905–11. doi: 10.1016/s0022-3565(25)24394-4.
superpathway of cholesterol biosynthesis

Accession ID: BioCyc:META_PWY66-5
  • 10.1073/pnas.112202799
 Mo C, Valachovic M, Randall SK, Nickels JT, Bard M. Protein-protein interactions among C-4 demethylation enzymes involved in yeast sterol biosynthesis. Proc Natl Acad Sci U S A. 2002 Jul 23;99(15):9739–44. PMID: 12119386; PMCID: PMC124998.
Cholesterol metabolism with Bloch and Kandutsch-Russell pathways

Accession ID: WikiPathways:WP4346
  • 10.3390/molecules18044002
 Acimovic J, Rozman D. Steroidal triterpenes of cholesterol synthesis. Molecules. 2013 Apr 04;18(4):4002–17. PMID: 23558541; PMCID: PMC6269928.