Pathways Knowlegdes

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Pathway DOIs Note
Drug ADME

Accession ID: Reactome:R-BTA-9748784
  • 10.1002/jps.21009
  • 10.2967/jnmt.117.199638
 Currie GM. Pharmacology, Part 2: Introduction to Pharmacokinetics. J Nucl Med Technol. 2018 Sep;46(3):221–30. doi: 10.2967/jnmt.117.199638. PMID: 29724803.; Ruiz-Garcia A, Bermejo M, Moss A, Casabo VG. Pharmacokinetics in Drug Discovery. Journal of Pharmaceutical Sciences. 2008 Feb;97(2):654–90. doi: 10.1002/jps.21009.; Pallasch TJ. Principles of pharmacotherapy: II. Pharmacokinetics. Anesth Prog. 1988 Jul;35(4):133–46. PMID: 3046441; PMCID: PMC2167950.
APAP ADME

Accession ID: Reactome:R-CEL-9753281
  • 10.1002/prp2.835
  • 10.1007/s10787-013-0172-x
  • 10.1007/s11095-013-1007-6
  • 10.2165/00003088-198207020-00001
 Esh CJ, Chrismas BCR, Mauger AR, Taylor L. Pharmacological hypotheses: Is acetaminophen selective in its cyclooxygenase inhibition? Pharmacol Res Perspect. 2021 Aug;9(4):e00835. PMID: 34278737; PMCID: PMC8287062.; Graham GG, Davies MJ, Day RO, Mohamudally A, Scott KF. The modern pharmacology of paracetamol: therapeutic actions, mechanism of action, metabolism, toxicity and recent pharmacological findings. Inflammopharmacology. 2013 Jun;21(3):201–32. doi: 10.1007/s10787-013-0172-x. PMID: 23719833.; McGill MR, Jaeschke H. Metabolism and Disposition of Acetaminophen: Recent Advances in Relation to Hepatotoxicity and Diagnosis. Pharmaceutical Research. 2013 Mar 06;30(9):2174–87. doi: 10.1007/s11095-013-1007-6.; Forrest JA, Clements JA, Prescott LF. Clinical pharmacokinetics of paracetamol. Clin Pharmacokinet. 1982 Mar;7(2):93–107. doi: 10.2165/00003088-198207020-00001. PMID: 7039926.
APAP ADME

Accession ID: Reactome:R-GGA-9753281
  • 10.1002/prp2.835
  • 10.1007/s10787-013-0172-x
  • 10.1007/s11095-013-1007-6
  • 10.2165/00003088-198207020-00001
 Esh CJ, Chrismas BCR, Mauger AR, Taylor L. Pharmacological hypotheses: Is acetaminophen selective in its cyclooxygenase inhibition? Pharmacol Res Perspect. 2021 Aug;9(4):e00835. PMID: 34278737; PMCID: PMC8287062.; Graham GG, Davies MJ, Day RO, Mohamudally A, Scott KF. The modern pharmacology of paracetamol: therapeutic actions, mechanism of action, metabolism, toxicity and recent pharmacological findings. Inflammopharmacology. 2013 Jun;21(3):201–32. doi: 10.1007/s10787-013-0172-x. PMID: 23719833.; McGill MR, Jaeschke H. Metabolism and Disposition of Acetaminophen: Recent Advances in Relation to Hepatotoxicity and Diagnosis. Pharmaceutical Research. 2013 Mar 06;30(9):2174–87. doi: 10.1007/s11095-013-1007-6.; Forrest JA, Clements JA, Prescott LF. Clinical pharmacokinetics of paracetamol. Clin Pharmacokinet. 1982 Mar;7(2):93–107. doi: 10.2165/00003088-198207020-00001. PMID: 7039926.
APAP ADME

Accession ID: Reactome:R-MMU-9753281
  • 10.1002/prp2.835
  • 10.1007/s10787-013-0172-x
  • 10.1007/s11095-013-1007-6
  • 10.2165/00003088-198207020-00001
 Esh CJ, Chrismas BCR, Mauger AR, Taylor L. Pharmacological hypotheses: Is acetaminophen selective in its cyclooxygenase inhibition? Pharmacol Res Perspect. 2021 Aug;9(4):e00835. PMID: 34278737; PMCID: PMC8287062.; Graham GG, Davies MJ, Day RO, Mohamudally A, Scott KF. The modern pharmacology of paracetamol: therapeutic actions, mechanism of action, metabolism, toxicity and recent pharmacological findings. Inflammopharmacology. 2013 Jun;21(3):201–32. doi: 10.1007/s10787-013-0172-x. PMID: 23719833.; McGill MR, Jaeschke H. Metabolism and Disposition of Acetaminophen: Recent Advances in Relation to Hepatotoxicity and Diagnosis. Pharmaceutical Research. 2013 Mar 06;30(9):2174–87. doi: 10.1007/s11095-013-1007-6.; Forrest JA, Clements JA, Prescott LF. Clinical pharmacokinetics of paracetamol. Clin Pharmacokinet. 1982 Mar;7(2):93–107. doi: 10.2165/00003088-198207020-00001. PMID: 7039926.
Drug ADME

Accession ID: Reactome:R-RNO-9748784
  • 10.1002/jps.21009
  • 10.2967/jnmt.117.199638
 Currie GM. Pharmacology, Part 2: Introduction to Pharmacokinetics. J Nucl Med Technol. 2018 Sep;46(3):221–30. doi: 10.2967/jnmt.117.199638. PMID: 29724803.; Ruiz-Garcia A, Bermejo M, Moss A, Casabo VG. Pharmacokinetics in Drug Discovery. Journal of Pharmaceutical Sciences. 2008 Feb;97(2):654–90. doi: 10.1002/jps.21009.; Pallasch TJ. Principles of pharmacotherapy: II. Pharmacokinetics. Anesth Prog. 1988 Jul;35(4):133–46. PMID: 3046441; PMCID: PMC2167950.
Drug ADME

Accession ID: Reactome:R-SSC-9748784
  • 10.1002/jps.21009
  • 10.2967/jnmt.117.199638
 Currie GM. Pharmacology, Part 2: Introduction to Pharmacokinetics. J Nucl Med Technol. 2018 Sep;46(3):221–30. doi: 10.2967/jnmt.117.199638. PMID: 29724803.; Ruiz-Garcia A, Bermejo M, Moss A, Casabo VG. Pharmacokinetics in Drug Discovery. Journal of Pharmaceutical Sciences. 2008 Feb;97(2):654–90. doi: 10.1002/jps.21009.; Pallasch TJ. Principles of pharmacotherapy: II. Pharmacokinetics. Anesth Prog. 1988 Jul;35(4):133–46. PMID: 3046441; PMCID: PMC2167950.
APAP ADME

Accession ID: Reactome:R-BTA-9753281
  • 10.1002/prp2.835
  • 10.1007/s10787-013-0172-x
  • 10.1007/s11095-013-1007-6
  • 10.2165/00003088-198207020-00001
 Esh CJ, Chrismas BCR, Mauger AR, Taylor L. Pharmacological hypotheses: Is acetaminophen selective in its cyclooxygenase inhibition? Pharmacol Res Perspect. 2021 Aug;9(4):e00835. PMID: 34278737; PMCID: PMC8287062.; Graham GG, Davies MJ, Day RO, Mohamudally A, Scott KF. The modern pharmacology of paracetamol: therapeutic actions, mechanism of action, metabolism, toxicity and recent pharmacological findings. Inflammopharmacology. 2013 Jun;21(3):201–32. doi: 10.1007/s10787-013-0172-x. PMID: 23719833.; McGill MR, Jaeschke H. Metabolism and Disposition of Acetaminophen: Recent Advances in Relation to Hepatotoxicity and Diagnosis. Pharmaceutical Research. 2013 Mar 06;30(9):2174–87. doi: 10.1007/s11095-013-1007-6.; Forrest JA, Clements JA, Prescott LF. Clinical pharmacokinetics of paracetamol. Clin Pharmacokinet. 1982 Mar;7(2):93–107. doi: 10.2165/00003088-198207020-00001. PMID: 7039926.
Drug ADME

Accession ID: Reactome:R-CFA-9748784
  • 10.1002/jps.21009
  • 10.2967/jnmt.117.199638
 Currie GM. Pharmacology, Part 2: Introduction to Pharmacokinetics. J Nucl Med Technol. 2018 Sep;46(3):221–30. doi: 10.2967/jnmt.117.199638. PMID: 29724803.; Ruiz-Garcia A, Bermejo M, Moss A, Casabo VG. Pharmacokinetics in Drug Discovery. Journal of Pharmaceutical Sciences. 2008 Feb;97(2):654–90. doi: 10.1002/jps.21009.; Pallasch TJ. Principles of pharmacotherapy: II. Pharmacokinetics. Anesth Prog. 1988 Jul;35(4):133–46. PMID: 3046441; PMCID: PMC2167950.
APAP ADME

Accession ID: Reactome:R-RNO-9753281
  • 10.1002/prp2.835
  • 10.1007/s10787-013-0172-x
  • 10.1007/s11095-013-1007-6
  • 10.2165/00003088-198207020-00001
 Esh CJ, Chrismas BCR, Mauger AR, Taylor L. Pharmacological hypotheses: Is acetaminophen selective in its cyclooxygenase inhibition? Pharmacol Res Perspect. 2021 Aug;9(4):e00835. PMID: 34278737; PMCID: PMC8287062.; Graham GG, Davies MJ, Day RO, Mohamudally A, Scott KF. The modern pharmacology of paracetamol: therapeutic actions, mechanism of action, metabolism, toxicity and recent pharmacological findings. Inflammopharmacology. 2013 Jun;21(3):201–32. doi: 10.1007/s10787-013-0172-x. PMID: 23719833.; McGill MR, Jaeschke H. Metabolism and Disposition of Acetaminophen: Recent Advances in Relation to Hepatotoxicity and Diagnosis. Pharmaceutical Research. 2013 Mar 06;30(9):2174–87. doi: 10.1007/s11095-013-1007-6.; Forrest JA, Clements JA, Prescott LF. Clinical pharmacokinetics of paracetamol. Clin Pharmacokinet. 1982 Mar;7(2):93–107. doi: 10.2165/00003088-198207020-00001. PMID: 7039926.
APAP ADME

Accession ID: Reactome:R-SSC-9753281
  • 10.1002/prp2.835
  • 10.1007/s10787-013-0172-x
  • 10.1007/s11095-013-1007-6
  • 10.2165/00003088-198207020-00001
 Esh CJ, Chrismas BCR, Mauger AR, Taylor L. Pharmacological hypotheses: Is acetaminophen selective in its cyclooxygenase inhibition? Pharmacol Res Perspect. 2021 Aug;9(4):e00835. PMID: 34278737; PMCID: PMC8287062.; Graham GG, Davies MJ, Day RO, Mohamudally A, Scott KF. The modern pharmacology of paracetamol: therapeutic actions, mechanism of action, metabolism, toxicity and recent pharmacological findings. Inflammopharmacology. 2013 Jun;21(3):201–32. doi: 10.1007/s10787-013-0172-x. PMID: 23719833.; McGill MR, Jaeschke H. Metabolism and Disposition of Acetaminophen: Recent Advances in Relation to Hepatotoxicity and Diagnosis. Pharmaceutical Research. 2013 Mar 06;30(9):2174–87. doi: 10.1007/s11095-013-1007-6.; Forrest JA, Clements JA, Prescott LF. Clinical pharmacokinetics of paracetamol. Clin Pharmacokinet. 1982 Mar;7(2):93–107. doi: 10.2165/00003088-198207020-00001. PMID: 7039926.
Drug ADME

Accession ID: Reactome:R-XTR-9748784
  • 10.1002/jps.21009
  • 10.2967/jnmt.117.199638
 Currie GM. Pharmacology, Part 2: Introduction to Pharmacokinetics. J Nucl Med Technol. 2018 Sep;46(3):221–30. doi: 10.2967/jnmt.117.199638. PMID: 29724803.; Ruiz-Garcia A, Bermejo M, Moss A, Casabo VG. Pharmacokinetics in Drug Discovery. Journal of Pharmaceutical Sciences. 2008 Feb;97(2):654–90. doi: 10.1002/jps.21009.; Pallasch TJ. Principles of pharmacotherapy: II. Pharmacokinetics. Anesth Prog. 1988 Jul;35(4):133–46. PMID: 3046441; PMCID: PMC2167950.
Drug ADME

Accession ID: Reactome:R-CEL-9748784
  • 10.1002/jps.21009
  • 10.2967/jnmt.117.199638
 Currie GM. Pharmacology, Part 2: Introduction to Pharmacokinetics. J Nucl Med Technol. 2018 Sep;46(3):221–30. doi: 10.2967/jnmt.117.199638. PMID: 29724803.; Ruiz-Garcia A, Bermejo M, Moss A, Casabo VG. Pharmacokinetics in Drug Discovery. Journal of Pharmaceutical Sciences. 2008 Feb;97(2):654–90. doi: 10.1002/jps.21009.; Pallasch TJ. Principles of pharmacotherapy: II. Pharmacokinetics. Anesth Prog. 1988 Jul;35(4):133–46. PMID: 3046441; PMCID: PMC2167950.
APAP ADME

Accession ID: Reactome:R-DRE-9753281
  • 10.1002/prp2.835
  • 10.1007/s10787-013-0172-x
  • 10.1007/s11095-013-1007-6
  • 10.2165/00003088-198207020-00001
 Esh CJ, Chrismas BCR, Mauger AR, Taylor L. Pharmacological hypotheses: Is acetaminophen selective in its cyclooxygenase inhibition? Pharmacol Res Perspect. 2021 Aug;9(4):e00835. PMID: 34278737; PMCID: PMC8287062.; Graham GG, Davies MJ, Day RO, Mohamudally A, Scott KF. The modern pharmacology of paracetamol: therapeutic actions, mechanism of action, metabolism, toxicity and recent pharmacological findings. Inflammopharmacology. 2013 Jun;21(3):201–32. doi: 10.1007/s10787-013-0172-x. PMID: 23719833.; McGill MR, Jaeschke H. Metabolism and Disposition of Acetaminophen: Recent Advances in Relation to Hepatotoxicity and Diagnosis. Pharmaceutical Research. 2013 Mar 06;30(9):2174–87. doi: 10.1007/s11095-013-1007-6.; Forrest JA, Clements JA, Prescott LF. Clinical pharmacokinetics of paracetamol. Clin Pharmacokinet. 1982 Mar;7(2):93–107. doi: 10.2165/00003088-198207020-00001. PMID: 7039926.
Drug ADME

Accession ID: Reactome:R-GGA-9748784
  • 10.1002/jps.21009
  • 10.2967/jnmt.117.199638
 Currie GM. Pharmacology, Part 2: Introduction to Pharmacokinetics. J Nucl Med Technol. 2018 Sep;46(3):221–30. doi: 10.2967/jnmt.117.199638. PMID: 29724803.; Ruiz-Garcia A, Bermejo M, Moss A, Casabo VG. Pharmacokinetics in Drug Discovery. Journal of Pharmaceutical Sciences. 2008 Feb;97(2):654–90. doi: 10.1002/jps.21009.; Pallasch TJ. Principles of pharmacotherapy: II. Pharmacokinetics. Anesth Prog. 1988 Jul;35(4):133–46. PMID: 3046441; PMCID: PMC2167950.
APAP ADME

Accession ID: Reactome:R-HSA-9753281
  • 10.1002/prp2.835
  • 10.1007/s10787-013-0172-x
  • 10.1007/s11095-013-1007-6
  • 10.2165/00003088-198207020-00001
 Esh CJ, Chrismas BCR, Mauger AR, Taylor L. Pharmacological hypotheses: Is acetaminophen selective in its cyclooxygenase inhibition? Pharmacol Res Perspect. 2021 Aug;9(4):e00835. PMID: 34278737; PMCID: PMC8287062.; Graham GG, Davies MJ, Day RO, Mohamudally A, Scott KF. The modern pharmacology of paracetamol: therapeutic actions, mechanism of action, metabolism, toxicity and recent pharmacological findings. Inflammopharmacology. 2013 Jun;21(3):201–32. doi: 10.1007/s10787-013-0172-x. PMID: 23719833.; McGill MR, Jaeschke H. Metabolism and Disposition of Acetaminophen: Recent Advances in Relation to Hepatotoxicity and Diagnosis. Pharmaceutical Research. 2013 Mar 06;30(9):2174–87. doi: 10.1007/s11095-013-1007-6.; Forrest JA, Clements JA, Prescott LF. Clinical pharmacokinetics of paracetamol. Clin Pharmacokinet. 1982 Mar;7(2):93–107. doi: 10.2165/00003088-198207020-00001. PMID: 7039926.
Drug ADME

Accession ID: Reactome:R-MMU-9748784
  • 10.1002/jps.21009
  • 10.2967/jnmt.117.199638
 Currie GM. Pharmacology, Part 2: Introduction to Pharmacokinetics. J Nucl Med Technol. 2018 Sep;46(3):221–30. doi: 10.2967/jnmt.117.199638. PMID: 29724803.; Ruiz-Garcia A, Bermejo M, Moss A, Casabo VG. Pharmacokinetics in Drug Discovery. Journal of Pharmaceutical Sciences. 2008 Feb;97(2):654–90. doi: 10.1002/jps.21009.; Pallasch TJ. Principles of pharmacotherapy: II. Pharmacokinetics. Anesth Prog. 1988 Jul;35(4):133–46. PMID: 3046441; PMCID: PMC2167950.
APAP ADME

Accession ID: Reactome:R-CFA-9753281
  • 10.1002/prp2.835
  • 10.1007/s10787-013-0172-x
  • 10.1007/s11095-013-1007-6
  • 10.2165/00003088-198207020-00001
 Esh CJ, Chrismas BCR, Mauger AR, Taylor L. Pharmacological hypotheses: Is acetaminophen selective in its cyclooxygenase inhibition? Pharmacol Res Perspect. 2021 Aug;9(4):e00835. PMID: 34278737; PMCID: PMC8287062.; Graham GG, Davies MJ, Day RO, Mohamudally A, Scott KF. The modern pharmacology of paracetamol: therapeutic actions, mechanism of action, metabolism, toxicity and recent pharmacological findings. Inflammopharmacology. 2013 Jun;21(3):201–32. doi: 10.1007/s10787-013-0172-x. PMID: 23719833.; McGill MR, Jaeschke H. Metabolism and Disposition of Acetaminophen: Recent Advances in Relation to Hepatotoxicity and Diagnosis. Pharmaceutical Research. 2013 Mar 06;30(9):2174–87. doi: 10.1007/s11095-013-1007-6.; Forrest JA, Clements JA, Prescott LF. Clinical pharmacokinetics of paracetamol. Clin Pharmacokinet. 1982 Mar;7(2):93–107. doi: 10.2165/00003088-198207020-00001. PMID: 7039926.
Drug ADME

Accession ID: Reactome:R-DRE-9748784
  • 10.1002/jps.21009
  • 10.2967/jnmt.117.199638
 Currie GM. Pharmacology, Part 2: Introduction to Pharmacokinetics. J Nucl Med Technol. 2018 Sep;46(3):221–30. doi: 10.2967/jnmt.117.199638. PMID: 29724803.; Ruiz-Garcia A, Bermejo M, Moss A, Casabo VG. Pharmacokinetics in Drug Discovery. Journal of Pharmaceutical Sciences. 2008 Feb;97(2):654–90. doi: 10.1002/jps.21009.; Pallasch TJ. Principles of pharmacotherapy: II. Pharmacokinetics. Anesth Prog. 1988 Jul;35(4):133–46. PMID: 3046441; PMCID: PMC2167950.
Drug ADME

Accession ID: Reactome:R-HSA-9748784
  • 10.1002/jps.21009
  • 10.2967/jnmt.117.199638
 Currie GM. Pharmacology, Part 2: Introduction to Pharmacokinetics. J Nucl Med Technol. 2018 Sep;46(3):221–30. doi: 10.2967/jnmt.117.199638. PMID: 29724803.; Ruiz-Garcia A, Bermejo M, Moss A, Casabo VG. Pharmacokinetics in Drug Discovery. Journal of Pharmaceutical Sciences. 2008 Feb;97(2):654–90. doi: 10.1002/jps.21009.; Pallasch TJ. Principles of pharmacotherapy: II. Pharmacokinetics. Anesth Prog. 1988 Jul;35(4):133–46. PMID: 3046441; PMCID: PMC2167950.
APAP ADME

Accession ID: Reactome:R-XTR-9753281
  • 10.1002/prp2.835
  • 10.1007/s10787-013-0172-x
  • 10.1007/s11095-013-1007-6
  • 10.2165/00003088-198207020-00001
 Esh CJ, Chrismas BCR, Mauger AR, Taylor L. Pharmacological hypotheses: Is acetaminophen selective in its cyclooxygenase inhibition? Pharmacol Res Perspect. 2021 Aug;9(4):e00835. PMID: 34278737; PMCID: PMC8287062.; Graham GG, Davies MJ, Day RO, Mohamudally A, Scott KF. The modern pharmacology of paracetamol: therapeutic actions, mechanism of action, metabolism, toxicity and recent pharmacological findings. Inflammopharmacology. 2013 Jun;21(3):201–32. doi: 10.1007/s10787-013-0172-x. PMID: 23719833.; McGill MR, Jaeschke H. Metabolism and Disposition of Acetaminophen: Recent Advances in Relation to Hepatotoxicity and Diagnosis. Pharmaceutical Research. 2013 Mar 06;30(9):2174–87. doi: 10.1007/s11095-013-1007-6.; Forrest JA, Clements JA, Prescott LF. Clinical pharmacokinetics of paracetamol. Clin Pharmacokinet. 1982 Mar;7(2):93–107. doi: 10.2165/00003088-198207020-00001. PMID: 7039926.