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Pathways Knowlegdes

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Pathway	DOIs	Note
hyperforin and adhyperforin biosynthesis Accession ID: BioCyc:META_PWY-5808	`10.1016/j.phytochem.2004.10.020` `10.1016/j.phytochem.2004.11.003` `10.1016/j.phytochem.2006.08.017` `10.1016/j.phytochem.2007.01.001` `10.1016/s0024-3205(01)00946-8` `10.1046/j.1432-1327.1999.00444.x` `10.1055/s-2006-961463` `10.1093/aob/mcm057`	Karppinen K, Hokkanen J, Tolonen A, Mattila S, Hohtola A. Biosynthesis of hyperforin and adhyperforin from amino acid precursors in shoot cultures of Hypericum perforatum. Phytochemistry. 2007 Apr;68(7):1038–45. doi: 10.1016/j.phytochem.2007.01.001. PMID: 17307206.; Soelberg J, Jorgensen LB, Jager AK. Hyperforin Accumulates in the Translucent Glands of Hypericum perforatum. Annals of Botany. 2007 Jan 26;99(6):1097–100. doi: 10.1093/aob/mcm057.; Beerhues L. Hyperforin. Phytochemistry. 2006 Oct;67(20):2201–7. doi: 10.1016/j.phytochem.2006.08.017. PMID: 16973193.; Boubakir Z, Beuerle T, Liu B, Beerhues L. The first prenylation step in hyperforin biosynthesis. Phytochemistry. 2005 Jan;66(1):51–7. doi: 10.1016/j.phytochem.2004.10.020. PMID: 15649510.; Klingauf P, Beuerle T, Mellenthin A, El-Moghazy SA, Boubakir Z, Beerhues L. Biosynthesis of the hyperforin skeleton in Hypericum calycinum cell cultures. Phytochemistry. 2005 Jan;66(2):139–45. doi: 10.1016/j.phytochem.2004.11.003. PMID: 15652570.; Jensen AG, Hansen SH, Nielsen EO. Adhyperforin as a contributor to the effect of Hypericum perforatum L. in biochemical models of antidepressant activity. Life Sci. 2001 Feb 23;68(14):1593–605. doi: 10.1016/s0024-3205(01)00946-8. PMID: 11263672.; Paniego NB, Zuurbier KWM, Fung S, van der Heijden R, Scheffer JJC, Verpoorte R. Phlorisovalerophenone synthase, a novel polyketide synthase from hop (Humulus lupulus L.) cones. European Journal of Biochemistry. 1999 Jun;262(2):612–6. doi: 10.1046/j.1432-1327.1999.00444.x.; Maisenbacher P, Kovar KA. Adhyperforin: A Homologue of Hyperforin from Hypericum perforatum. Planta Med. 1992 Jun;58(3):291–3. doi: 10.1055/s-2006-961463. PMID: 17226474.
superpathway of bitter acids biosynthesis Accession ID: BioCyc:META_PWY-5134	`10.1046/j.1432-1327.1999.00444.x` `10.1046/j.1432-1327.1999.00518.x` `10.1104/pp.114.253682`	Li H, Ban Z, Qin H, Ma L, King AJ, Wang G. A heteromeric membrane-bound prenyltransferase complex from hop catalyzes three sequential aromatic prenylations in the bitter acid pathway. Plant Physiol. 2015 Mar;167(3):650–9. PMID: 25564559; PMCID: PMC4348772.; Goese M, Kammhuber K, Bacher A, Zenk MH, Eisenreich W. Biosynthesis of bitter acids in hops. A (13)C-NMR and (2)H-NMR study on the building blocks of humulone. Eur J Biochem. 1999 Jul;263(2):447–54. doi: 10.1046/j.1432-1327.1999.00518.x. PMID: 10406953.; Paniego NB, Zuurbier KWM, Fung S, van der Heijden R, Scheffer JJC, Verpoorte R. Phlorisovalerophenone synthase, a novel polyketide synthase from hop (Humulus lupulus L.) cones. European Journal of Biochemistry. 1999 Jun;262(2):612–6. doi: 10.1046/j.1432-1327.1999.00444.x.
lupulone and humulone biosynthesis Accession ID: BioCyc:META_PWY-5132	`10.1046/j.1432-1327.1999.00444.x` `10.1046/j.1432-1327.1999.00518.x` `10.1104/pp.114.253682`	Li H, Ban Z, Qin H, Ma L, King AJ, Wang G. A heteromeric membrane-bound prenyltransferase complex from hop catalyzes three sequential aromatic prenylations in the bitter acid pathway. Plant Physiol. 2015 Mar;167(3):650–9. PMID: 25564559; PMCID: PMC4348772.; Goese M, Kammhuber K, Bacher A, Zenk MH, Eisenreich W. Biosynthesis of bitter acids in hops. A (13)C-NMR and (2)H-NMR study on the building blocks of humulone. Eur J Biochem. 1999 Jul;263(2):447–54. doi: 10.1046/j.1432-1327.1999.00518.x. PMID: 10406953.; Paniego NB, Zuurbier KWM, Fung S, van der Heijden R, Scheffer JJC, Verpoorte R. Phlorisovalerophenone synthase, a novel polyketide synthase from hop (Humulus lupulus L.) cones. European Journal of Biochemistry. 1999 Jun;262(2):612–6. doi: 10.1046/j.1432-1327.1999.00444.x.
superpathway of bitter acids biosynthesis Accession ID: PlantCyc:HOP_PWY-5134	`10.1046/j.1432-1327.1999.00444.x` `10.1046/j.1432-1327.1999.00518.x`	Goese M, Kammhuber K, Bacher A, Zenk MH, Eisenreich W. Biosynthesis of bitter acids in hops. A (13)C-NMR and (2)H-NMR study on the building blocks of humulone. Eur J Biochem. 1999 Jul;263(2):447–54. doi: 10.1046/j.1432-1327.1999.00518.x. PMID: 10406953.; Paniego NB, Zuurbier KWM, Fung S, van der Heijden R, Scheffer JJC, Verpoorte R. Phlorisovalerophenone synthase, a novel polyketide synthase from hop (Humulus lupulus L.) cones. European Journal of Biochemistry. 1999 Jun;262(2):612–6. doi: 10.1046/j.1432-1327.1999.00444.x.
lupulone and humulone biosynthesis Accession ID: PlantCyc:PLANT_PWY-5132	`10.1046/j.1432-1327.1999.00444.x` `10.1046/j.1432-1327.1999.00518.x`	Goese M, Kammhuber K, Bacher A, Zenk MH, Eisenreich W. Biosynthesis of bitter acids in hops. A (13)C-NMR and (2)H-NMR study on the building blocks of humulone. Eur J Biochem. 1999 Jul;263(2):447–54. doi: 10.1046/j.1432-1327.1999.00518.x. PMID: 10406953.; Paniego NB, Zuurbier KWM, Fung S, van der Heijden R, Scheffer JJC, Verpoorte R. Phlorisovalerophenone synthase, a novel polyketide synthase from hop (Humulus lupulus L.) cones. European Journal of Biochemistry. 1999 Jun;262(2):612–6. doi: 10.1046/j.1432-1327.1999.00444.x.
lupulone and humulone biosynthesis Accession ID: PlantCyc:HOP_PWY-5132	`10.1046/j.1432-1327.1999.00444.x` `10.1046/j.1432-1327.1999.00518.x`	Goese M, Kammhuber K, Bacher A, Zenk MH, Eisenreich W. Biosynthesis of bitter acids in hops. A (13)C-NMR and (2)H-NMR study on the building blocks of humulone. Eur J Biochem. 1999 Jul;263(2):447–54. doi: 10.1046/j.1432-1327.1999.00518.x. PMID: 10406953.; Paniego NB, Zuurbier KWM, Fung S, van der Heijden R, Scheffer JJC, Verpoorte R. Phlorisovalerophenone synthase, a novel polyketide synthase from hop (Humulus lupulus L.) cones. European Journal of Biochemistry. 1999 Jun;262(2):612–6. doi: 10.1046/j.1432-1327.1999.00444.x.
superpathway of bitter acids biosynthesis Accession ID: PlantCyc:PLANT_PWY-5134	`10.1046/j.1432-1327.1999.00444.x` `10.1046/j.1432-1327.1999.00518.x`	Goese M, Kammhuber K, Bacher A, Zenk MH, Eisenreich W. Biosynthesis of bitter acids in hops. A (13)C-NMR and (2)H-NMR study on the building blocks of humulone. Eur J Biochem. 1999 Jul;263(2):447–54. doi: 10.1046/j.1432-1327.1999.00518.x. PMID: 10406953.; Paniego NB, Zuurbier KWM, Fung S, van der Heijden R, Scheffer JJC, Verpoorte R. Phlorisovalerophenone synthase, a novel polyketide synthase from hop (Humulus lupulus L.) cones. European Journal of Biochemistry. 1999 Jun;262(2):612–6. doi: 10.1046/j.1432-1327.1999.00444.x.
hyperforin and adhyperforin biosynthesis Accession ID: PlantCyc:PLANT_PWY-5808	`10.1016/j.phytochem.2006.08.017` `10.1046/j.1432-1327.1999.00444.x`	Beerhues L. Hyperforin. Phytochemistry. 2006 Oct;67(20):2201–7. doi: 10.1016/j.phytochem.2006.08.017. PMID: 16973193.; Paniego NB, Zuurbier KWM, Fung S, van der Heijden R, Scheffer JJC, Verpoorte R. Phlorisovalerophenone synthase, a novel polyketide synthase from hop (Humulus lupulus L.) cones. European Journal of Biochemistry. 1999 Jun;262(2):612–6. doi: 10.1046/j.1432-1327.1999.00444.x.