Pathways Knowlegdes

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Pathway DOIs Note
ascorbate glutathione cycle

Accession ID: BioCyc:META_PWY-2261
  • 10.1016/0003-9861(80)90495-6
  • 10.1021/bi00013a023
  • 10.1021/bi049343q
  • 10.1021/bi0606849
  • 10.1042/bj1860377
  • 10.1074/jbc.m307525200
  • 10.1093/jexbot/53.372.1305
  • 10.1104/pp.114.1.275
  • 10.1146/annurev.arplant.49.1.249
 Macdonald IK, Badyal SK, Ghamsari L, Moody PCE, Raven EL. Interaction of Ascorbate Peroxidase with Substrates: A Mechanistic and Structural Analysis. Biochemistry. 2006 Jun 01;45(25):7808–17. doi: 10.1021/bi0606849.; Sharp KH, Moody PC, Brown KA, Raven EL. Crystal structure of the ascorbate peroxidase-salicylhydroxamic acid complex. Biochemistry. 2004 Jul 13;43(27):8644–51. doi: 10.1021/bi049343q. PMID: 15236572.; Chew O, Whelan J, Millar AH. Molecular Definition of the Ascorbate-Glutathione Cycle in Arabidopsis Mitochondria Reveals Dual Targeting of Antioxidant Defenses in Plants. Journal of Biological Chemistry. 2003 Nov;278(47):46869–77. doi: 10.1074/jbc.m307525200.; Shigeoka S, Ishikawa T, Tamoi M, Miyagawa Y, Takeda T, Yabuta Y, Yoshimura K. Regulation and function of ascorbate peroxidase isoenzymes. 2002 May 15;53(372):1305–19. doi: 10.1093/jxb/53.372.1305.; Noctor G, Foyer CH. ASCORBATE AND GLUTATHIONE: Keeping Active Oxygen Under Control. Annu Rev Plant Physiol Plant Mol Biol. 1998 Jun;49():249–79. doi: 10.1146/annurev.arplant.49.1.249. PMID: 15012235.; Jimenez A, Hernandez JA, Del Rio LA, Sevilla F. Evidence for the Presence of the Ascorbate-Glutathione Cycle in Mitochondria and Peroxisomes of Pea Leaves. Plant Physiol. 1997 May;114(1):275–84. PMID: 12223704; PMCID: PMC158303.; Patterson WR, Poulos TL. Crystal structure of recombinant pea cytosolic ascorbate peroxidase. Biochemistry. 1995 Apr 04;34(13):4331–41. doi: 10.1021/bi00013a023. PMID: 7703247.; Shigeoka S, Nakano Y, Kitaoka S. Purification and some properties of l-ascorbic acid-specific peroxidase in Euglena gracilis z. Archives of Biochemistry and Biophysics. 1980 Apr;201(1):121–7. doi: 10.1016/0003-9861(80)90495-6.; Shigeoka S, Nakano Y, Kitaoka S. Metabolism of hydrogen peroxide in Euglena gracilis Z by L-ascorbic acid peroxidase. Biochem J. 1980 Jan 15;186(1):377–80. PMID: 6768357; PMCID: PMC1161541.
ascorbate recycling (cytosolic)

Accession ID: BioCyc:META_PWY-6370
  • 10.1021/bi0606849
  • 10.1111/j.1742-4658.2006.05607.x
 Linster CL, Van Schaftingen E. Vitamin C. Biosynthesis, recycling and degradation in mammals. FEBS J. 2007 Jan;274(1):1–22. doi: 10.1111/j.1742-4658.2006.05607.x. PMID: 17222174.; Macdonald IK, Badyal SK, Ghamsari L, Moody PCE, Raven EL. Interaction of Ascorbate Peroxidase with Substrates: A Mechanistic and Structural Analysis. Biochemistry. 2006 Jun 01;45(25):7808–17. doi: 10.1021/bi0606849.
ascorbate biosynthesis

Accession ID: BioCyc:LEISH_PWY3IU-472
  • 10.1016/j.pt.2007.02.004
  • 10.1073/pnas.0504251102
 Opperdoes FR, Coombs GH. Metabolism of Leishmania: proven and predicted. Trends Parasitol. 2007 Apr;23(4):149–58. doi: 10.1016/j.pt.2007.02.004. PMID: 17320480.; Wilkinson SR, Prathalingam SR, Taylor MC, Horn D, Kelly JM. Vitamin C biosynthesis in trypanosomes: a role for the glycosome. Proc Natl Acad Sci U S A. 2005 Aug 16;102(33):11645–50. PMID: 16087875; PMCID: PMC1187986.
ascorbate recycling (cytosolic)

Accession ID: BioCyc:HUMAN_PWY-6370
  • 10.1111/j.1742-4658.2006.05607.x
 Linster CL, Van Schaftingen E. Vitamin C. Biosynthesis, recycling and degradation in mammals. FEBS J. 2007 Jan;274(1):1–22. doi: 10.1111/j.1742-4658.2006.05607.x. PMID: 17222174.
ascorbate glutathione cycle

Accession ID: PlantCyc:SPIRODELA_PWY-2261		 -
ascorbate glutathione cycle

Accession ID: PlantCyc:SUGARBEET_PWY-2261		 -
ascorbate glutathione cycle

Accession ID: PlantCyc:ACOERULEA_PWY-2261		 -
ascorbate glutathione cycle

Accession ID: PlantCyc:TOMATO_PWY-2261		 -
ascorbate recycling (cytosolic)

Accession ID: PlantCyc:VCARTERI_PWY-6370		 -
ascorbate glutathione cycle

Accession ID: PlantCyc:BANANA_PWY-2261		 -
ascorbate glutathione cycle

Accession ID: PlantCyc:BRACHYPODIUM_PWY-2261		 -
ascorbate glutathione cycle

Accession ID: PlantCyc:CARNATION_PWY-2261		 -
ascorbate glutathione cycle

Accession ID: PlantCyc:CCAPSULARIS_PWY-2261		 -
ascorbate glutathione cycle

Accession ID: PlantCyc:CGIGANTEA_PWY-2261		 -
ascorbate glutathione cycle

Accession ID: PlantCyc:SACREDLOTUS_PWY-2261		 -
ascorbate glutathione cycle

Accession ID: PlantCyc:SWEETCHERRY_PWY-2261		 -
ascorbate glutathione cycle

Accession ID: PlantCyc:CSATIVA_PK_PWY-2261		 -
ascorbate glutathione cycle

Accession ID: PlantCyc:MDOMESTICA_PWY-2261		 -
ascorbate glutathione cycle

Accession ID: PlantCyc:EUROPEANPEAR_PWY-2261		 -
ascorbate glutathione cycle

Accession ID: PlantCyc:MPOLYMORPHA_PWY-2261		 -