Pathways Knowlegdes

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Pathway DOIs Note
Vitamin D (calciferol) metabolism

Accession ID: Reactome:R-CEL-196791
  • 10.1002/cbf.2835
  • 10.1016/j.bbagrm.2017.07.002
  • 10.1016/j.beem.2015.06.006
  • 10.1016/j.mayocp.2013.05.011
  • 10.1152/physrev.00014.2015
  • 10.1371/journal.pone.0058725
 Neme A, Seuter S, Carlberg C. Selective regulation of biological processes by vitamin D based on the spatio-temporal cistrome of its receptor. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. 2017 Sep;1860(9):952–61. doi: 10.1016/j.bbagrm.2017.07.002.; Christakos S, Dhawan P, Verstuyf A, Verlinden L, Carmeliet G. Vitamin D: Metabolism, Molecular Mechanism of Action, and Pleiotropic Effects. Physiological Reviews. 2016 Jan;96(1):365–408. doi: 10.1152/physrev.00014.2015.; Delanghe JR, Speeckaert R, Speeckaert MM. Behind the scenes of vitamin D binding protein: More than vitamin D binding. Best Practice & Research Clinical Endocrinology & Metabolism. 2015 Oct;29(5):773–86. doi: 10.1016/j.beem.2015.06.006.; Hossein-nezhad A, Holick MF. Vitamin D for Health: A Global Perspective. Mayo Clinic Proceedings. 2013 Jul;88(7):720–55. doi: 10.1016/j.mayocp.2013.05.011.; Hossein-nezhad A, Spira A, Holick MF. Influence of Vitamin D Status and Vitamin D3 Supplementation on Genome Wide Expression of White Blood Cells: A Randomized Double-Blind Clinical Trial. PLoS ONE. 2013 Mar 20;8(3):e58725. doi: 10.1371/journal.pone.0058725.; Chun RF. New perspectives on the vitamin D binding protein. Cell Biochemistry & Function. 2012 Apr 23;30(6):445–56. doi: 10.1002/cbf.2835.
Metabolism

Accession ID: Reactome:R-BTA-1430728		 -
Metabolism of lipids

Accession ID: Reactome:R-BTA-556833		 -
Vitamin D (calciferol) metabolism

Accession ID: Reactome:R-BTA-196791
  • 10.1002/cbf.2835
  • 10.1016/j.bbagrm.2017.07.002
  • 10.1016/j.beem.2015.06.006
  • 10.1016/j.mayocp.2013.05.011
  • 10.1152/physrev.00014.2015
  • 10.1371/journal.pone.0058725
 Neme A, Seuter S, Carlberg C. Selective regulation of biological processes by vitamin D based on the spatio-temporal cistrome of its receptor. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. 2017 Sep;1860(9):952–61. doi: 10.1016/j.bbagrm.2017.07.002.; Christakos S, Dhawan P, Verstuyf A, Verlinden L, Carmeliet G. Vitamin D: Metabolism, Molecular Mechanism of Action, and Pleiotropic Effects. Physiological Reviews. 2016 Jan;96(1):365–408. doi: 10.1152/physrev.00014.2015.; Delanghe JR, Speeckaert R, Speeckaert MM. Behind the scenes of vitamin D binding protein: More than vitamin D binding. Best Practice & Research Clinical Endocrinology & Metabolism. 2015 Oct;29(5):773–86. doi: 10.1016/j.beem.2015.06.006.; Hossein-nezhad A, Holick MF. Vitamin D for Health: A Global Perspective. Mayo Clinic Proceedings. 2013 Jul;88(7):720–55. doi: 10.1016/j.mayocp.2013.05.011.; Hossein-nezhad A, Spira A, Holick MF. Influence of Vitamin D Status and Vitamin D3 Supplementation on Genome Wide Expression of White Blood Cells: A Randomized Double-Blind Clinical Trial. PLoS ONE. 2013 Mar 20;8(3):e58725. doi: 10.1371/journal.pone.0058725.; Chun RF. New perspectives on the vitamin D binding protein. Cell Biochemistry & Function. 2012 Apr 23;30(6):445–56. doi: 10.1002/cbf.2835.
Metabolism

Accession ID: Reactome:R-CFA-1430728		 -
Metabolism of lipids

Accession ID: Reactome:R-CFA-556833		 -
Vitamin D (calciferol) metabolism

Accession ID: Reactome:R-CFA-196791
  • 10.1002/cbf.2835
  • 10.1016/j.bbagrm.2017.07.002
  • 10.1016/j.beem.2015.06.006
  • 10.1016/j.mayocp.2013.05.011
  • 10.1152/physrev.00014.2015
  • 10.1371/journal.pone.0058725
 Neme A, Seuter S, Carlberg C. Selective regulation of biological processes by vitamin D based on the spatio-temporal cistrome of its receptor. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. 2017 Sep;1860(9):952–61. doi: 10.1016/j.bbagrm.2017.07.002.; Christakos S, Dhawan P, Verstuyf A, Verlinden L, Carmeliet G. Vitamin D: Metabolism, Molecular Mechanism of Action, and Pleiotropic Effects. Physiological Reviews. 2016 Jan;96(1):365–408. doi: 10.1152/physrev.00014.2015.; Delanghe JR, Speeckaert R, Speeckaert MM. Behind the scenes of vitamin D binding protein: More than vitamin D binding. Best Practice & Research Clinical Endocrinology & Metabolism. 2015 Oct;29(5):773–86. doi: 10.1016/j.beem.2015.06.006.; Hossein-nezhad A, Holick MF. Vitamin D for Health: A Global Perspective. Mayo Clinic Proceedings. 2013 Jul;88(7):720–55. doi: 10.1016/j.mayocp.2013.05.011.; Hossein-nezhad A, Spira A, Holick MF. Influence of Vitamin D Status and Vitamin D3 Supplementation on Genome Wide Expression of White Blood Cells: A Randomized Double-Blind Clinical Trial. PLoS ONE. 2013 Mar 20;8(3):e58725. doi: 10.1371/journal.pone.0058725.; Chun RF. New perspectives on the vitamin D binding protein. Cell Biochemistry & Function. 2012 Apr 23;30(6):445–56. doi: 10.1002/cbf.2835.
Vitamin D (calciferol) metabolism

Accession ID: Reactome:R-DME-196791
  • 10.1002/cbf.2835
  • 10.1016/j.bbagrm.2017.07.002
  • 10.1016/j.beem.2015.06.006
  • 10.1016/j.mayocp.2013.05.011
  • 10.1152/physrev.00014.2015
  • 10.1371/journal.pone.0058725
 Neme A, Seuter S, Carlberg C. Selective regulation of biological processes by vitamin D based on the spatio-temporal cistrome of its receptor. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. 2017 Sep;1860(9):952–61. doi: 10.1016/j.bbagrm.2017.07.002.; Christakos S, Dhawan P, Verstuyf A, Verlinden L, Carmeliet G. Vitamin D: Metabolism, Molecular Mechanism of Action, and Pleiotropic Effects. Physiological Reviews. 2016 Jan;96(1):365–408. doi: 10.1152/physrev.00014.2015.; Delanghe JR, Speeckaert R, Speeckaert MM. Behind the scenes of vitamin D binding protein: More than vitamin D binding. Best Practice & Research Clinical Endocrinology & Metabolism. 2015 Oct;29(5):773–86. doi: 10.1016/j.beem.2015.06.006.; Hossein-nezhad A, Holick MF. Vitamin D for Health: A Global Perspective. Mayo Clinic Proceedings. 2013 Jul;88(7):720–55. doi: 10.1016/j.mayocp.2013.05.011.; Hossein-nezhad A, Spira A, Holick MF. Influence of Vitamin D Status and Vitamin D3 Supplementation on Genome Wide Expression of White Blood Cells: A Randomized Double-Blind Clinical Trial. PLoS ONE. 2013 Mar 20;8(3):e58725. doi: 10.1371/journal.pone.0058725.; Chun RF. New perspectives on the vitamin D binding protein. Cell Biochemistry & Function. 2012 Apr 23;30(6):445–56. doi: 10.1002/cbf.2835.
Vitamin D (calciferol) metabolism

Accession ID: Reactome:R-HSA-196791
  • 10.1002/cbf.2835
  • 10.1016/j.bbagrm.2017.07.002
  • 10.1016/j.beem.2015.06.006
  • 10.1016/j.mayocp.2013.05.011
  • 10.1152/physrev.00014.2015
  • 10.1371/journal.pone.0058725
 Neme A, Seuter S, Carlberg C. Selective regulation of biological processes by vitamin D based on the spatio-temporal cistrome of its receptor. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. 2017 Sep;1860(9):952–61. doi: 10.1016/j.bbagrm.2017.07.002.; Christakos S, Dhawan P, Verstuyf A, Verlinden L, Carmeliet G. Vitamin D: Metabolism, Molecular Mechanism of Action, and Pleiotropic Effects. Physiological Reviews. 2016 Jan;96(1):365–408. doi: 10.1152/physrev.00014.2015.; Delanghe JR, Speeckaert R, Speeckaert MM. Behind the scenes of vitamin D binding protein: More than vitamin D binding. Best Practice & Research Clinical Endocrinology & Metabolism. 2015 Oct;29(5):773–86. doi: 10.1016/j.beem.2015.06.006.; Hossein-nezhad A, Holick MF. Vitamin D for Health: A Global Perspective. Mayo Clinic Proceedings. 2013 Jul;88(7):720–55. doi: 10.1016/j.mayocp.2013.05.011.; Hossein-nezhad A, Spira A, Holick MF. Influence of Vitamin D Status and Vitamin D3 Supplementation on Genome Wide Expression of White Blood Cells: A Randomized Double-Blind Clinical Trial. PLoS ONE. 2013 Mar 20;8(3):e58725. doi: 10.1371/journal.pone.0058725.; Chun RF. New perspectives on the vitamin D binding protein. Cell Biochemistry & Function. 2012 Apr 23;30(6):445–56. doi: 10.1002/cbf.2835.
Metabolism

Accession ID: Reactome:R-MMU-1430728		 -
Metabolism of lipids

Accession ID: Reactome:R-MMU-556833		 -
Metabolism of steroids

Accession ID: Reactome:R-MMU-8957322
  • 10.1007/bf00054556
  • 10.1146/annurev.biochem.72.121801.161712
  • 10.1152/ajprenal.00336.2004
  • 10.1194/jlr.r800054-jlr200
  • 10.1210/er.2003-0030
 Brown MS, Goldstein JL. Cholesterol feedback: from Schoenheimer's bottle to Scap's MELADL. Journal of Lipid Research. 2009 Apr;50():S15–27. doi: 10.1194/jlr.r800054-jlr200.; Dusso AS, Brown AJ, Slatopolsky E. Vitamin D. American Journal of Physiology-Renal Physiology. 2005 Jul;289(1):F8–F28. doi: 10.1152/ajprenal.00336.2004.; Payne AH, Hales DB. Overview of steroidogenic enzymes in the pathway from cholesterol to active steroid hormones. Endocr Rev. 2004 Dec;25(6):947–70. doi: 10.1210/er.2003-0030. PMID: 15583024.; Russell DW. The enzymes, regulation, and genetics of bile acid synthesis. Annu Rev Biochem. 2003;72():137–74. doi: 10.1146/annurev.biochem.72.121801.161712. PMID: 12543708.; Russell DW. Cholesterol biosynthesis and metabolism. Cardiovasc Drugs Ther. 1992 Apr;6(2):103–10. doi: 10.1007/bf00054556. PMID: 1390320.
Metabolism of steroids

Accession ID: Reactome:R-BTA-8957322
  • 10.1007/bf00054556
  • 10.1146/annurev.biochem.72.121801.161712
  • 10.1152/ajprenal.00336.2004
  • 10.1194/jlr.r800054-jlr200
  • 10.1210/er.2003-0030
 Brown MS, Goldstein JL. Cholesterol feedback: from Schoenheimer's bottle to Scap's MELADL. Journal of Lipid Research. 2009 Apr;50():S15–27. doi: 10.1194/jlr.r800054-jlr200.; Dusso AS, Brown AJ, Slatopolsky E. Vitamin D. American Journal of Physiology-Renal Physiology. 2005 Jul;289(1):F8–F28. doi: 10.1152/ajprenal.00336.2004.; Payne AH, Hales DB. Overview of steroidogenic enzymes in the pathway from cholesterol to active steroid hormones. Endocr Rev. 2004 Dec;25(6):947–70. doi: 10.1210/er.2003-0030. PMID: 15583024.; Russell DW. The enzymes, regulation, and genetics of bile acid synthesis. Annu Rev Biochem. 2003;72():137–74. doi: 10.1146/annurev.biochem.72.121801.161712. PMID: 12543708.; Russell DW. Cholesterol biosynthesis and metabolism. Cardiovasc Drugs Ther. 1992 Apr;6(2):103–10. doi: 10.1007/bf00054556. PMID: 1390320.
Metabolism of lipids

Accession ID: Reactome:R-CEL-556833		 -
Metabolism of steroids

Accession ID: Reactome:R-CEL-8957322
  • 10.1007/bf00054556
  • 10.1146/annurev.biochem.72.121801.161712
  • 10.1152/ajprenal.00336.2004
  • 10.1194/jlr.r800054-jlr200
  • 10.1210/er.2003-0030
 Brown MS, Goldstein JL. Cholesterol feedback: from Schoenheimer's bottle to Scap's MELADL. Journal of Lipid Research. 2009 Apr;50():S15–27. doi: 10.1194/jlr.r800054-jlr200.; Dusso AS, Brown AJ, Slatopolsky E. Vitamin D. American Journal of Physiology-Renal Physiology. 2005 Jul;289(1):F8–F28. doi: 10.1152/ajprenal.00336.2004.; Payne AH, Hales DB. Overview of steroidogenic enzymes in the pathway from cholesterol to active steroid hormones. Endocr Rev. 2004 Dec;25(6):947–70. doi: 10.1210/er.2003-0030. PMID: 15583024.; Russell DW. The enzymes, regulation, and genetics of bile acid synthesis. Annu Rev Biochem. 2003;72():137–74. doi: 10.1146/annurev.biochem.72.121801.161712. PMID: 12543708.; Russell DW. Cholesterol biosynthesis and metabolism. Cardiovasc Drugs Ther. 1992 Apr;6(2):103–10. doi: 10.1007/bf00054556. PMID: 1390320.
Metabolism of steroids

Accession ID: Reactome:R-CFA-8957322
  • 10.1007/bf00054556
  • 10.1146/annurev.biochem.72.121801.161712
  • 10.1152/ajprenal.00336.2004
  • 10.1194/jlr.r800054-jlr200
  • 10.1210/er.2003-0030
 Brown MS, Goldstein JL. Cholesterol feedback: from Schoenheimer's bottle to Scap's MELADL. Journal of Lipid Research. 2009 Apr;50():S15–27. doi: 10.1194/jlr.r800054-jlr200.; Dusso AS, Brown AJ, Slatopolsky E. Vitamin D. American Journal of Physiology-Renal Physiology. 2005 Jul;289(1):F8–F28. doi: 10.1152/ajprenal.00336.2004.; Payne AH, Hales DB. Overview of steroidogenic enzymes in the pathway from cholesterol to active steroid hormones. Endocr Rev. 2004 Dec;25(6):947–70. doi: 10.1210/er.2003-0030. PMID: 15583024.; Russell DW. The enzymes, regulation, and genetics of bile acid synthesis. Annu Rev Biochem. 2003;72():137–74. doi: 10.1146/annurev.biochem.72.121801.161712. PMID: 12543708.; Russell DW. Cholesterol biosynthesis and metabolism. Cardiovasc Drugs Ther. 1992 Apr;6(2):103–10. doi: 10.1007/bf00054556. PMID: 1390320.
Metabolism

Accession ID: Reactome:R-DME-1430728		 -
Metabolism of lipids

Accession ID: Reactome:R-HSA-556833
  • 10.1016/s0006-291x(02)00623-x
  • 10.1152/physiolgenomics.90211.2008
 Rome S, Lecomte V, Meugnier E, Rieusset J, Debard C, Euthine V, Vidal H, Lefai E. Microarray analyses of SREBP-1a and SREBP-1c target genes identify new regulatory pathways in muscle. Physiol Genomics. 2008 Aug 15;34(3):327–37. doi: 10.1152/physiolgenomics.90211.2008. PMID: 18559965.; Nagai M, Sakakibara J, Nakamura Y, Gejyo F, Ono T. SREBP-2 and NF-Y are involved in the transcriptional regulation of squalene epoxidase. Biochemical and Biophysical Research Communications. 2002 Jul;295(1):74–80. doi: 10.1016/s0006-291x(02)00623-x.
Metabolism

Accession ID: Reactome:R-SSC-1430728		 -
Metabolism of lipids

Accession ID: Reactome:R-SSC-556833		 -