Pathways Knowlegdes

Necessitatibus eius consequatur ex aliquid fuga eum quidem sint consectetur velit

Pathway DOIs Note
Response to metal ions

Accession ID: Reactome:R-GGA-5660526
  • 10.1016/j.abb.2007.03.019
  • 10.1016/j.bbamcr.2012.01.005
  • 10.1042/bst0361262
  • 10.3892/mmr.2014.2969
 Dong G, Chen H, Qi M, Dou Y, Wang Q. Balance between metallothionein and metal response element binding transcription factor 1 is mediated by zinc ions (review). Mol Med Rep. 2015 Mar;11(3):1582–6. doi: 10.3892/mmr.2014.2969. PMID: 25405524.; Günther V, Lindert U, Schaffner W. The taste of heavy metals: Gene regulation by MTF-1. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 2012 Sep;1823(9):1416–25. doi: 10.1016/j.bbamcr.2012.01.005.; Jackson KA, Valentine RA, Coneyworth LJ, Mathers JC, Ford D. Mechanisms of mammalian zinc-regulated gene expression. Biochem Soc Trans. 2008 Dec;36(Pt 6):1262–6. doi: 10.1042/bst0361262. PMID: 19021537.; Laity JH, Andrews GK. Understanding the mechanisms of zinc-sensing by metal-response element binding transcription factor-1 (MTF-1). Archives of Biochemistry and Biophysics. 2007 Jul;463(2):201–10. doi: 10.1016/j.abb.2007.03.019.
Metallothioneins bind metals

Accession ID: Reactome:R-DRE-5661231
  • 10.1007/s00775-011-0799-2
  • 10.1007/s00775-011-0800-0
  • 10.1039/c2mt20081c
  • 10.1080/10409230091169168
  • 10.1186/1477-7819-9-54
  • 10.1515/bmc-2012-0049
  • 10.2147/ijn.s42019
 Sharma S, Rais A, Sandhu R, Nel W, Ebadi M. Clinical significance of metallothioneins in cell therapy and nanomedicine. Int J Nanomedicine. 2013;8():1477–88. PMID: 23620664; PMCID: PMC3633583.; Atrian S, Capdevila M. Metallothionein-protein interactions. Biomol Concepts. 2013 Apr;4(2):143–60. doi: 10.1515/bmc-2012-0049. PMID: 25436572.; Babula P, Masarik M, Adam V, Eckschlager T, Stiborova M, Trnkova L, Skutkova H, Provaznik I, Hubalek J, Kizek R. Mammalian metallothioneins: properties and functions. Metallomics. 2012 Aug;4(8):739–50. doi: 10.1039/c2mt20081c. PMID: 22791193.; Maret W. Redox biochemistry of mammalian metallothioneins. JBIC Journal of Biological Inorganic Chemistry. 2011 Jun 07;16(7):1079–86. doi: 10.1007/s00775-011-0800-0.; Vašák M, Meloni G. Chemistry and biology of mammalian metallothioneins. JBIC Journal of Biological Inorganic Chemistry. 2011 Jun 07;16(7):1067. doi: 10.1007/s00775-011-0799-2.; Thirumoorthy N, Shyam Sunder A, Manisenthil Kumar K, Senthil kumar M, Ganesh G, Chatterjee M. A Review of Metallothionein Isoforms and their Role in Pathophysiology. World Journal of Surgical Oncology. 2011 May 20;9(1):54. doi: 10.1186/1477-7819-9-54.; Miles AT, Hawksworth GM, Beattie JH, Rodilla V. Induction, Regulation, Degradation, and Biological Significance of Mammalian Metallothioneins. Critical Reviews in Biochemistry and Molecular Biology. 2000 Jan;35(1):35–70. doi: 10.1080/10409230091169168.
Metallothioneins bind metals

Accession ID: Reactome:R-GGA-5661231
  • 10.1007/s00775-011-0799-2
  • 10.1007/s00775-011-0800-0
  • 10.1039/c2mt20081c
  • 10.1080/10409230091169168
  • 10.1186/1477-7819-9-54
  • 10.1515/bmc-2012-0049
  • 10.2147/ijn.s42019
 Sharma S, Rais A, Sandhu R, Nel W, Ebadi M. Clinical significance of metallothioneins in cell therapy and nanomedicine. Int J Nanomedicine. 2013;8():1477–88. PMID: 23620664; PMCID: PMC3633583.; Atrian S, Capdevila M. Metallothionein-protein interactions. Biomol Concepts. 2013 Apr;4(2):143–60. doi: 10.1515/bmc-2012-0049. PMID: 25436572.; Babula P, Masarik M, Adam V, Eckschlager T, Stiborova M, Trnkova L, Skutkova H, Provaznik I, Hubalek J, Kizek R. Mammalian metallothioneins: properties and functions. Metallomics. 2012 Aug;4(8):739–50. doi: 10.1039/c2mt20081c. PMID: 22791193.; Maret W. Redox biochemistry of mammalian metallothioneins. JBIC Journal of Biological Inorganic Chemistry. 2011 Jun 07;16(7):1079–86. doi: 10.1007/s00775-011-0800-0.; Vašák M, Meloni G. Chemistry and biology of mammalian metallothioneins. JBIC Journal of Biological Inorganic Chemistry. 2011 Jun 07;16(7):1067. doi: 10.1007/s00775-011-0799-2.; Thirumoorthy N, Shyam Sunder A, Manisenthil Kumar K, Senthil kumar M, Ganesh G, Chatterjee M. A Review of Metallothionein Isoforms and their Role in Pathophysiology. World Journal of Surgical Oncology. 2011 May 20;9(1):54. doi: 10.1186/1477-7819-9-54.; Miles AT, Hawksworth GM, Beattie JH, Rodilla V. Induction, Regulation, Degradation, and Biological Significance of Mammalian Metallothioneins. Critical Reviews in Biochemistry and Molecular Biology. 2000 Jan;35(1):35–70. doi: 10.1080/10409230091169168.
Response to metal ions

Accession ID: Reactome:R-DRE-5660526
  • 10.1016/j.abb.2007.03.019
  • 10.1016/j.bbamcr.2012.01.005
  • 10.1042/bst0361262
  • 10.3892/mmr.2014.2969
 Dong G, Chen H, Qi M, Dou Y, Wang Q. Balance between metallothionein and metal response element binding transcription factor 1 is mediated by zinc ions (review). Mol Med Rep. 2015 Mar;11(3):1582–6. doi: 10.3892/mmr.2014.2969. PMID: 25405524.; Günther V, Lindert U, Schaffner W. The taste of heavy metals: Gene regulation by MTF-1. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 2012 Sep;1823(9):1416–25. doi: 10.1016/j.bbamcr.2012.01.005.; Jackson KA, Valentine RA, Coneyworth LJ, Mathers JC, Ford D. Mechanisms of mammalian zinc-regulated gene expression. Biochem Soc Trans. 2008 Dec;36(Pt 6):1262–6. doi: 10.1042/bst0361262. PMID: 19021537.; Laity JH, Andrews GK. Understanding the mechanisms of zinc-sensing by metal-response element binding transcription factor-1 (MTF-1). Archives of Biochemistry and Biophysics. 2007 Jul;463(2):201–10. doi: 10.1016/j.abb.2007.03.019.
Cellular responses to stimuli

Accession ID: Reactome:R-BTA-8953897
  • 10.1146/annurev.physiol.67.040403.103635
 Kültz D. Molecular and evolutionary basis of the cellular stress response. Annu Rev Physiol. 2005;67():225–57. doi: 10.1146/annurev.physiol.67.040403.103635. PMID: 15709958.
Response to metal ions

Accession ID: Reactome:R-CFA-5660526
  • 10.1016/j.abb.2007.03.019
  • 10.1016/j.bbamcr.2012.01.005
  • 10.1042/bst0361262
  • 10.3892/mmr.2014.2969
 Dong G, Chen H, Qi M, Dou Y, Wang Q. Balance between metallothionein and metal response element binding transcription factor 1 is mediated by zinc ions (review). Mol Med Rep. 2015 Mar;11(3):1582–6. doi: 10.3892/mmr.2014.2969. PMID: 25405524.; Günther V, Lindert U, Schaffner W. The taste of heavy metals: Gene regulation by MTF-1. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 2012 Sep;1823(9):1416–25. doi: 10.1016/j.bbamcr.2012.01.005.; Jackson KA, Valentine RA, Coneyworth LJ, Mathers JC, Ford D. Mechanisms of mammalian zinc-regulated gene expression. Biochem Soc Trans. 2008 Dec;36(Pt 6):1262–6. doi: 10.1042/bst0361262. PMID: 19021537.; Laity JH, Andrews GK. Understanding the mechanisms of zinc-sensing by metal-response element binding transcription factor-1 (MTF-1). Archives of Biochemistry and Biophysics. 2007 Jul;463(2):201–10. doi: 10.1016/j.abb.2007.03.019.
Metallothioneins bind metals

Accession ID: Reactome:R-MMU-5661231
  • 10.1007/s00775-011-0799-2
  • 10.1007/s00775-011-0800-0
  • 10.1039/c2mt20081c
  • 10.1080/10409230091169168
  • 10.1186/1477-7819-9-54
  • 10.1515/bmc-2012-0049
  • 10.2147/ijn.s42019
 Sharma S, Rais A, Sandhu R, Nel W, Ebadi M. Clinical significance of metallothioneins in cell therapy and nanomedicine. Int J Nanomedicine. 2013;8():1477–88. PMID: 23620664; PMCID: PMC3633583.; Atrian S, Capdevila M. Metallothionein-protein interactions. Biomol Concepts. 2013 Apr;4(2):143–60. doi: 10.1515/bmc-2012-0049. PMID: 25436572.; Babula P, Masarik M, Adam V, Eckschlager T, Stiborova M, Trnkova L, Skutkova H, Provaznik I, Hubalek J, Kizek R. Mammalian metallothioneins: properties and functions. Metallomics. 2012 Aug;4(8):739–50. doi: 10.1039/c2mt20081c. PMID: 22791193.; Maret W. Redox biochemistry of mammalian metallothioneins. JBIC Journal of Biological Inorganic Chemistry. 2011 Jun 07;16(7):1079–86. doi: 10.1007/s00775-011-0800-0.; Vašák M, Meloni G. Chemistry and biology of mammalian metallothioneins. JBIC Journal of Biological Inorganic Chemistry. 2011 Jun 07;16(7):1067. doi: 10.1007/s00775-011-0799-2.; Thirumoorthy N, Shyam Sunder A, Manisenthil Kumar K, Senthil kumar M, Ganesh G, Chatterjee M. A Review of Metallothionein Isoforms and their Role in Pathophysiology. World Journal of Surgical Oncology. 2011 May 20;9(1):54. doi: 10.1186/1477-7819-9-54.; Miles AT, Hawksworth GM, Beattie JH, Rodilla V. Induction, Regulation, Degradation, and Biological Significance of Mammalian Metallothioneins. Critical Reviews in Biochemistry and Molecular Biology. 2000 Jan;35(1):35–70. doi: 10.1080/10409230091169168.
Response to metal ions

Accession ID: Reactome:R-RNO-5660526
  • 10.1016/j.abb.2007.03.019
  • 10.1016/j.bbamcr.2012.01.005
  • 10.1042/bst0361262
  • 10.3892/mmr.2014.2969
 Dong G, Chen H, Qi M, Dou Y, Wang Q. Balance between metallothionein and metal response element binding transcription factor 1 is mediated by zinc ions (review). Mol Med Rep. 2015 Mar;11(3):1582–6. doi: 10.3892/mmr.2014.2969. PMID: 25405524.; Günther V, Lindert U, Schaffner W. The taste of heavy metals: Gene regulation by MTF-1. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 2012 Sep;1823(9):1416–25. doi: 10.1016/j.bbamcr.2012.01.005.; Jackson KA, Valentine RA, Coneyworth LJ, Mathers JC, Ford D. Mechanisms of mammalian zinc-regulated gene expression. Biochem Soc Trans. 2008 Dec;36(Pt 6):1262–6. doi: 10.1042/bst0361262. PMID: 19021537.; Laity JH, Andrews GK. Understanding the mechanisms of zinc-sensing by metal-response element binding transcription factor-1 (MTF-1). Archives of Biochemistry and Biophysics. 2007 Jul;463(2):201–10. doi: 10.1016/j.abb.2007.03.019.
Cellular responses to stimuli

Accession ID: Reactome:R-SSC-8953897
  • 10.1146/annurev.physiol.67.040403.103635
 Kültz D. Molecular and evolutionary basis of the cellular stress response. Annu Rev Physiol. 2005;67():225–57. doi: 10.1146/annurev.physiol.67.040403.103635. PMID: 15709958.
Cellular responses to stimuli

Accession ID: Reactome:R-CFA-8953897
  • 10.1146/annurev.physiol.67.040403.103635
 Kültz D. Molecular and evolutionary basis of the cellular stress response. Annu Rev Physiol. 2005;67():225–57. doi: 10.1146/annurev.physiol.67.040403.103635. PMID: 15709958.
Cellular responses to stimuli

Accession ID: Reactome:R-DRE-8953897
  • 10.1146/annurev.physiol.67.040403.103635
 Kültz D. Molecular and evolutionary basis of the cellular stress response. Annu Rev Physiol. 2005;67():225–57. doi: 10.1146/annurev.physiol.67.040403.103635. PMID: 15709958.
Response to metal ions

Accession ID: Reactome:R-HSA-5660526
  • 10.1016/j.abb.2007.03.019
  • 10.1016/j.bbamcr.2012.01.005
  • 10.1042/bst0361262
  • 10.3892/mmr.2014.2969
 Dong G, Chen H, Qi M, Dou Y, Wang Q. Balance between metallothionein and metal response element binding transcription factor 1 is mediated by zinc ions (review). Mol Med Rep. 2015 Mar;11(3):1582–6. doi: 10.3892/mmr.2014.2969. PMID: 25405524.; Günther V, Lindert U, Schaffner W. The taste of heavy metals: Gene regulation by MTF-1. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 2012 Sep;1823(9):1416–25. doi: 10.1016/j.bbamcr.2012.01.005.; Jackson KA, Valentine RA, Coneyworth LJ, Mathers JC, Ford D. Mechanisms of mammalian zinc-regulated gene expression. Biochem Soc Trans. 2008 Dec;36(Pt 6):1262–6. doi: 10.1042/bst0361262. PMID: 19021537.; Laity JH, Andrews GK. Understanding the mechanisms of zinc-sensing by metal-response element binding transcription factor-1 (MTF-1). Archives of Biochemistry and Biophysics. 2007 Jul;463(2):201–10. doi: 10.1016/j.abb.2007.03.019.
Response to metal ions

Accession ID: Reactome:R-MMU-5660526
  • 10.1016/j.abb.2007.03.019
  • 10.1016/j.bbamcr.2012.01.005
  • 10.1042/bst0361262
  • 10.3892/mmr.2014.2969
 Dong G, Chen H, Qi M, Dou Y, Wang Q. Balance between metallothionein and metal response element binding transcription factor 1 is mediated by zinc ions (review). Mol Med Rep. 2015 Mar;11(3):1582–6. doi: 10.3892/mmr.2014.2969. PMID: 25405524.; Günther V, Lindert U, Schaffner W. The taste of heavy metals: Gene regulation by MTF-1. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 2012 Sep;1823(9):1416–25. doi: 10.1016/j.bbamcr.2012.01.005.; Jackson KA, Valentine RA, Coneyworth LJ, Mathers JC, Ford D. Mechanisms of mammalian zinc-regulated gene expression. Biochem Soc Trans. 2008 Dec;36(Pt 6):1262–6. doi: 10.1042/bst0361262. PMID: 19021537.; Laity JH, Andrews GK. Understanding the mechanisms of zinc-sensing by metal-response element binding transcription factor-1 (MTF-1). Archives of Biochemistry and Biophysics. 2007 Jul;463(2):201–10. doi: 10.1016/j.abb.2007.03.019.
Cellular responses to stimuli

Accession ID: Reactome:R-RNO-8953897
  • 10.1146/annurev.physiol.67.040403.103635
 Kültz D. Molecular and evolutionary basis of the cellular stress response. Annu Rev Physiol. 2005;67():225–57. doi: 10.1146/annurev.physiol.67.040403.103635. PMID: 15709958.
Response to metal ions

Accession ID: Reactome:R-BTA-5660526
  • 10.1016/j.abb.2007.03.019
  • 10.1016/j.bbamcr.2012.01.005
  • 10.1042/bst0361262
  • 10.3892/mmr.2014.2969
 Dong G, Chen H, Qi M, Dou Y, Wang Q. Balance between metallothionein and metal response element binding transcription factor 1 is mediated by zinc ions (review). Mol Med Rep. 2015 Mar;11(3):1582–6. doi: 10.3892/mmr.2014.2969. PMID: 25405524.; Günther V, Lindert U, Schaffner W. The taste of heavy metals: Gene regulation by MTF-1. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 2012 Sep;1823(9):1416–25. doi: 10.1016/j.bbamcr.2012.01.005.; Jackson KA, Valentine RA, Coneyworth LJ, Mathers JC, Ford D. Mechanisms of mammalian zinc-regulated gene expression. Biochem Soc Trans. 2008 Dec;36(Pt 6):1262–6. doi: 10.1042/bst0361262. PMID: 19021537.; Laity JH, Andrews GK. Understanding the mechanisms of zinc-sensing by metal-response element binding transcription factor-1 (MTF-1). Archives of Biochemistry and Biophysics. 2007 Jul;463(2):201–10. doi: 10.1016/j.abb.2007.03.019.
Metallothioneins bind metals

Accession ID: Reactome:R-CFA-5661231
  • 10.1007/s00775-011-0799-2
  • 10.1007/s00775-011-0800-0
  • 10.1039/c2mt20081c
  • 10.1080/10409230091169168
  • 10.1186/1477-7819-9-54
  • 10.1515/bmc-2012-0049
  • 10.2147/ijn.s42019
 Sharma S, Rais A, Sandhu R, Nel W, Ebadi M. Clinical significance of metallothioneins in cell therapy and nanomedicine. Int J Nanomedicine. 2013;8():1477–88. PMID: 23620664; PMCID: PMC3633583.; Atrian S, Capdevila M. Metallothionein-protein interactions. Biomol Concepts. 2013 Apr;4(2):143–60. doi: 10.1515/bmc-2012-0049. PMID: 25436572.; Babula P, Masarik M, Adam V, Eckschlager T, Stiborova M, Trnkova L, Skutkova H, Provaznik I, Hubalek J, Kizek R. Mammalian metallothioneins: properties and functions. Metallomics. 2012 Aug;4(8):739–50. doi: 10.1039/c2mt20081c. PMID: 22791193.; Maret W. Redox biochemistry of mammalian metallothioneins. JBIC Journal of Biological Inorganic Chemistry. 2011 Jun 07;16(7):1079–86. doi: 10.1007/s00775-011-0800-0.; Vašák M, Meloni G. Chemistry and biology of mammalian metallothioneins. JBIC Journal of Biological Inorganic Chemistry. 2011 Jun 07;16(7):1067. doi: 10.1007/s00775-011-0799-2.; Thirumoorthy N, Shyam Sunder A, Manisenthil Kumar K, Senthil kumar M, Ganesh G, Chatterjee M. A Review of Metallothionein Isoforms and their Role in Pathophysiology. World Journal of Surgical Oncology. 2011 May 20;9(1):54. doi: 10.1186/1477-7819-9-54.; Miles AT, Hawksworth GM, Beattie JH, Rodilla V. Induction, Regulation, Degradation, and Biological Significance of Mammalian Metallothioneins. Critical Reviews in Biochemistry and Molecular Biology. 2000 Jan;35(1):35–70. doi: 10.1080/10409230091169168.
Metallothioneins bind metals

Accession ID: Reactome:R-HSA-5661231
  • 10.1007/s00775-011-0799-2
  • 10.1007/s00775-011-0800-0
  • 10.1039/c2mt20081c
  • 10.1080/10409230091169168
  • 10.1186/1477-7819-9-54
  • 10.1515/bmc-2012-0049
  • 10.2147/ijn.s42019
 Sharma S, Rais A, Sandhu R, Nel W, Ebadi M. Clinical significance of metallothioneins in cell therapy and nanomedicine. Int J Nanomedicine. 2013;8():1477–88. PMID: 23620664; PMCID: PMC3633583.; Atrian S, Capdevila M. Metallothionein-protein interactions. Biomol Concepts. 2013 Apr;4(2):143–60. doi: 10.1515/bmc-2012-0049. PMID: 25436572.; Babula P, Masarik M, Adam V, Eckschlager T, Stiborova M, Trnkova L, Skutkova H, Provaznik I, Hubalek J, Kizek R. Mammalian metallothioneins: properties and functions. Metallomics. 2012 Aug;4(8):739–50. doi: 10.1039/c2mt20081c. PMID: 22791193.; Maret W. Redox biochemistry of mammalian metallothioneins. JBIC Journal of Biological Inorganic Chemistry. 2011 Jun 07;16(7):1079–86. doi: 10.1007/s00775-011-0800-0.; Vašák M, Meloni G. Chemistry and biology of mammalian metallothioneins. JBIC Journal of Biological Inorganic Chemistry. 2011 Jun 07;16(7):1067. doi: 10.1007/s00775-011-0799-2.; Thirumoorthy N, Shyam Sunder A, Manisenthil Kumar K, Senthil kumar M, Ganesh G, Chatterjee M. A Review of Metallothionein Isoforms and their Role in Pathophysiology. World Journal of Surgical Oncology. 2011 May 20;9(1):54. doi: 10.1186/1477-7819-9-54.; Miles AT, Hawksworth GM, Beattie JH, Rodilla V. Induction, Regulation, Degradation, and Biological Significance of Mammalian Metallothioneins. Critical Reviews in Biochemistry and Molecular Biology. 2000 Jan;35(1):35–70. doi: 10.1080/10409230091169168.
Metallothioneins bind metals

Accession ID: Reactome:R-RNO-5661231
  • 10.1007/s00775-011-0799-2
  • 10.1007/s00775-011-0800-0
  • 10.1039/c2mt20081c
  • 10.1080/10409230091169168
  • 10.1186/1477-7819-9-54
  • 10.1515/bmc-2012-0049
  • 10.2147/ijn.s42019
 Sharma S, Rais A, Sandhu R, Nel W, Ebadi M. Clinical significance of metallothioneins in cell therapy and nanomedicine. Int J Nanomedicine. 2013;8():1477–88. PMID: 23620664; PMCID: PMC3633583.; Atrian S, Capdevila M. Metallothionein-protein interactions. Biomol Concepts. 2013 Apr;4(2):143–60. doi: 10.1515/bmc-2012-0049. PMID: 25436572.; Babula P, Masarik M, Adam V, Eckschlager T, Stiborova M, Trnkova L, Skutkova H, Provaznik I, Hubalek J, Kizek R. Mammalian metallothioneins: properties and functions. Metallomics. 2012 Aug;4(8):739–50. doi: 10.1039/c2mt20081c. PMID: 22791193.; Maret W. Redox biochemistry of mammalian metallothioneins. JBIC Journal of Biological Inorganic Chemistry. 2011 Jun 07;16(7):1079–86. doi: 10.1007/s00775-011-0800-0.; Vašák M, Meloni G. Chemistry and biology of mammalian metallothioneins. JBIC Journal of Biological Inorganic Chemistry. 2011 Jun 07;16(7):1067. doi: 10.1007/s00775-011-0799-2.; Thirumoorthy N, Shyam Sunder A, Manisenthil Kumar K, Senthil kumar M, Ganesh G, Chatterjee M. A Review of Metallothionein Isoforms and their Role in Pathophysiology. World Journal of Surgical Oncology. 2011 May 20;9(1):54. doi: 10.1186/1477-7819-9-54.; Miles AT, Hawksworth GM, Beattie JH, Rodilla V. Induction, Regulation, Degradation, and Biological Significance of Mammalian Metallothioneins. Critical Reviews in Biochemistry and Molecular Biology. 2000 Jan;35(1):35–70. doi: 10.1080/10409230091169168.
Response to metal ions

Accession ID: Reactome:R-SSC-5660526
  • 10.1016/j.abb.2007.03.019
  • 10.1016/j.bbamcr.2012.01.005
  • 10.1042/bst0361262
  • 10.3892/mmr.2014.2969
 Dong G, Chen H, Qi M, Dou Y, Wang Q. Balance between metallothionein and metal response element binding transcription factor 1 is mediated by zinc ions (review). Mol Med Rep. 2015 Mar;11(3):1582–6. doi: 10.3892/mmr.2014.2969. PMID: 25405524.; Günther V, Lindert U, Schaffner W. The taste of heavy metals: Gene regulation by MTF-1. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 2012 Sep;1823(9):1416–25. doi: 10.1016/j.bbamcr.2012.01.005.; Jackson KA, Valentine RA, Coneyworth LJ, Mathers JC, Ford D. Mechanisms of mammalian zinc-regulated gene expression. Biochem Soc Trans. 2008 Dec;36(Pt 6):1262–6. doi: 10.1042/bst0361262. PMID: 19021537.; Laity JH, Andrews GK. Understanding the mechanisms of zinc-sensing by metal-response element binding transcription factor-1 (MTF-1). Archives of Biochemistry and Biophysics. 2007 Jul;463(2):201–10. doi: 10.1016/j.abb.2007.03.019.
Metallothioneins bind metals

Accession ID: Reactome:R-BTA-5661231
  • 10.1007/s00775-011-0799-2
  • 10.1007/s00775-011-0800-0
  • 10.1039/c2mt20081c
  • 10.1080/10409230091169168
  • 10.1186/1477-7819-9-54
  • 10.1515/bmc-2012-0049
  • 10.2147/ijn.s42019
 Sharma S, Rais A, Sandhu R, Nel W, Ebadi M. Clinical significance of metallothioneins in cell therapy and nanomedicine. Int J Nanomedicine. 2013;8():1477–88. PMID: 23620664; PMCID: PMC3633583.; Atrian S, Capdevila M. Metallothionein-protein interactions. Biomol Concepts. 2013 Apr;4(2):143–60. doi: 10.1515/bmc-2012-0049. PMID: 25436572.; Babula P, Masarik M, Adam V, Eckschlager T, Stiborova M, Trnkova L, Skutkova H, Provaznik I, Hubalek J, Kizek R. Mammalian metallothioneins: properties and functions. Metallomics. 2012 Aug;4(8):739–50. doi: 10.1039/c2mt20081c. PMID: 22791193.; Maret W. Redox biochemistry of mammalian metallothioneins. JBIC Journal of Biological Inorganic Chemistry. 2011 Jun 07;16(7):1079–86. doi: 10.1007/s00775-011-0800-0.; Vašák M, Meloni G. Chemistry and biology of mammalian metallothioneins. JBIC Journal of Biological Inorganic Chemistry. 2011 Jun 07;16(7):1067. doi: 10.1007/s00775-011-0799-2.; Thirumoorthy N, Shyam Sunder A, Manisenthil Kumar K, Senthil kumar M, Ganesh G, Chatterjee M. A Review of Metallothionein Isoforms and their Role in Pathophysiology. World Journal of Surgical Oncology. 2011 May 20;9(1):54. doi: 10.1186/1477-7819-9-54.; Miles AT, Hawksworth GM, Beattie JH, Rodilla V. Induction, Regulation, Degradation, and Biological Significance of Mammalian Metallothioneins. Critical Reviews in Biochemistry and Molecular Biology. 2000 Jan;35(1):35–70. doi: 10.1080/10409230091169168.