Pathways Knowlegdes
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| Pathway | DOIs | Note |
|---|---|---|
| superpathway of testosterone and androsterone degradation Accession ID: BioCyc:META_PWY-6937 |
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van der Geize R, Grommen AWF, Hessels GI, Jacobs AAC, Dijkhuizen L. The Steroid Catabolic Pathway of the Intracellular Pathogen Rhodococcus equi Is Important for Pathogenesis and a Target for Vaccine Development. PLoS Pathog. 2011 Aug 25;7(8):e1002181. doi: 10.1371/journal.ppat.1002181.; Kreit J, Sampson NS. Cholesterol oxidase: physiological functions. The FEBS Journal. 2009 Nov 16;276(23):6844–56. doi: 10.1111/j.1742-4658.2009.07378.x.; Petrusma M, Dijkhuizen L, van der Geize R. Rhodococcus rhodochrous DSM 43269 3-ketosteroid 9alpha-hydroxylase, a two-component iron-sulfur-containing monooxygenase with subtle steroid substrate specificity. Appl Environ Microbiol. 2009 Aug;75(16):5300–7. PMID: 19561185; PMCID: PMC2725467.; Horinouchi M, Hayashi T, Koshino H, Kurita T, Kudo T. Identification of 9,17-Dioxo-1,2,3,4,10,19-Hexanorandrostan-5-oic Acid, 4-Hydroxy-2-Oxohexanoic Acid, and 2-Hydroxyhexa-2,4-Dienoic Acid and Related Enzymes Involved in Testosterone Degradation in Comamonas testosteroni TA441. Appl Environ Microbiol. 2005 Sep;71(9):5275–81. doi: 10.1128/aem.71.9.5275-5281.2005.; Horinouchi M, Hayashi T, Yamamoto T, Kudo T. A New Bacterial Steroid Degradation Gene Cluster in Comamonas testosteroni TA441 Which Consists of Aromatic-Compound Degradation Genes for Seco-Steroids and 3-Ketosteroid Dehydrogenase Genes. Appl Environ Microbiol. 2003 Aug;69(8):4421–30. doi: 10.1128/aem.69.8.4421-4430.2003.; Horinouchi M, Hayashi T, Koshino H, Yamamoto T, Kudo T. Gene Encoding the Hydrolase for the Product of the meta -Cleavage Reaction in Testosterone Degradation by Comamonas testosteroni. Appl Environ Microbiol. 2003 Apr;69(4):2139–52. doi: 10.1128/aem.69.4.2139-2152.2003.; Florin C, Köhler T, Grandguillot M, Plesiat P. Comamonas testosteroni 3-ketosteroid-delta 4(5 alpha)-dehydrogenase: gene and protein characterization. J Bacteriol. 1996 Jun;178(11):3322–30. doi: 10.1128/jb.178.11.3322-3330.1996. |
| superpathway of testosterone and androsterone degradation Accession ID: BioCyc:MTBCDC1551_PWY-6937 |
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| androstenedione degradation Accession ID: BioCyc:META_PWY-6944 |
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van der Geize R, Grommen AWF, Hessels GI, Jacobs AAC, Dijkhuizen L. The Steroid Catabolic Pathway of the Intracellular Pathogen Rhodococcus equi Is Important for Pathogenesis and a Target for Vaccine Development. PLoS Pathog. 2011 Aug 25;7(8):e1002181. doi: 10.1371/journal.ppat.1002181.; Kreit J, Sampson NS. Cholesterol oxidase: physiological functions. The FEBS Journal. 2009 Nov 16;276(23):6844–56. doi: 10.1111/j.1742-4658.2009.07378.x.; Petrusma M, Dijkhuizen L, van der Geize R. Rhodococcus rhodochrous DSM 43269 3-ketosteroid 9alpha-hydroxylase, a two-component iron-sulfur-containing monooxygenase with subtle steroid substrate specificity. Appl Environ Microbiol. 2009 Aug;75(16):5300–7. PMID: 19561185; PMCID: PMC2725467.; Horinouchi M, Hayashi T, Koshino H, Kurita T, Kudo T. Identification of 9,17-Dioxo-1,2,3,4,10,19-Hexanorandrostan-5-oic Acid, 4-Hydroxy-2-Oxohexanoic Acid, and 2-Hydroxyhexa-2,4-Dienoic Acid and Related Enzymes Involved in Testosterone Degradation in Comamonas testosteroni TA441. Appl Environ Microbiol. 2005 Sep;71(9):5275–81. doi: 10.1128/aem.71.9.5275-5281.2005.; Horinouchi M, Hayashi T, Yamamoto T, Kudo T. A New Bacterial Steroid Degradation Gene Cluster in Comamonas testosteroni TA441 Which Consists of Aromatic-Compound Degradation Genes for Seco-Steroids and 3-Ketosteroid Dehydrogenase Genes. Appl Environ Microbiol. 2003 Aug;69(8):4421–30. doi: 10.1128/aem.69.8.4421-4430.2003.; Horinouchi M, Hayashi T, Koshino H, Yamamoto T, Kudo T. Gene Encoding the Hydrolase for the Product of the meta -Cleavage Reaction in Testosterone Degradation by Comamonas testosteroni. Appl Environ Microbiol. 2003 Apr;69(4):2139–52. doi: 10.1128/aem.69.4.2139-2152.2003. |
| superpathway of cholesterol degradation II (cholesterol dehydrogenase) Accession ID: BioCyc:MTBH37RV_PWY-6947 |
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| superpathway of cholesterol degradation II (cholesterol dehydrogenase) Accession ID: BioCyc:MTBCDC1551_PWY-6947 |
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| superpathway of cholesterol degradation II (cholesterol dehydrogenase) Accession ID: BioCyc:META_PWY-6947 |
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Thomas ST, VanderVen BC, Sherman DR, Russell DG, Sampson NS. Pathway profiling in Mycobacterium tuberculosis: elucidation of cholesterol-derived catabolite and enzymes that catalyze its metabolism. J Biol Chem. 2011 Dec 23;286(51):43668–78. PMID: 22045806; PMCID: PMC3243565.; van der Geize R, Grommen AWF, Hessels GI, Jacobs AAC, Dijkhuizen L. The Steroid Catabolic Pathway of the Intracellular Pathogen Rhodococcus equi Is Important for Pathogenesis and a Target for Vaccine Development. PLoS Pathog. 2011 Aug 25;7(8):e1002181. doi: 10.1371/journal.ppat.1002181.; Kreit J, Sampson NS. Cholesterol oxidase: physiological functions. The FEBS Journal. 2009 Nov 16;276(23):6844–56. doi: 10.1111/j.1742-4658.2009.07378.x.; Petrusma M, Dijkhuizen L, van der Geize R. Rhodococcus rhodochrous DSM 43269 3-ketosteroid 9alpha-hydroxylase, a two-component iron-sulfur-containing monooxygenase with subtle steroid substrate specificity. Appl Environ Microbiol. 2009 Aug;75(16):5300–7. PMID: 19561185; PMCID: PMC2725467.; Yang X, Dubnau E, Smith I, Sampson NS. Rv1106c from Mycobacterium tuberculosis Is a 3ß-Hydroxysteroid Dehydrogenase. Biochemistry. 2007 Jul 14;46(31):9058–67. doi: 10.1021/bi700688x.; Horinouchi M, Hayashi T, Koshino H, Kurita T, Kudo T. Identification of 9,17-Dioxo-1,2,3,4,10,19-Hexanorandrostan-5-oic Acid, 4-Hydroxy-2-Oxohexanoic Acid, and 2-Hydroxyhexa-2,4-Dienoic Acid and Related Enzymes Involved in Testosterone Degradation in Comamonas testosteroni TA441. Appl Environ Microbiol. 2005 Sep;71(9):5275–81. doi: 10.1128/aem.71.9.5275-5281.2005. |
| superpathway of cholesterol degradation I (cholesterol oxidase) Accession ID: BioCyc:META_PWY-6928 |
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Thomas ST, VanderVen BC, Sherman DR, Russell DG, Sampson NS. Pathway profiling in Mycobacterium tuberculosis: elucidation of cholesterol-derived catabolite and enzymes that catalyze its metabolism. J Biol Chem. 2011 Dec 23;286(51):43668–78. PMID: 22045806; PMCID: PMC3243565.; van der Geize R, Grommen AWF, Hessels GI, Jacobs AAC, Dijkhuizen L. The Steroid Catabolic Pathway of the Intracellular Pathogen Rhodococcus equi Is Important for Pathogenesis and a Target for Vaccine Development. PLoS Pathog. 2011 Aug 25;7(8):e1002181. doi: 10.1371/journal.ppat.1002181.; Kreit J, Sampson NS. Cholesterol oxidase: physiological functions. The FEBS Journal. 2009 Nov 16;276(23):6844–56. doi: 10.1111/j.1742-4658.2009.07378.x.; Petrusma M, Dijkhuizen L, van der Geize R. Rhodococcus rhodochrous DSM 43269 3-ketosteroid 9alpha-hydroxylase, a two-component iron-sulfur-containing monooxygenase with subtle steroid substrate specificity. Appl Environ Microbiol. 2009 Aug;75(16):5300–7. PMID: 19561185; PMCID: PMC2725467.; Horinouchi M, Hayashi T, Koshino H, Kurita T, Kudo T. Identification of 9,17-Dioxo-1,2,3,4,10,19-Hexanorandrostan-5-oic Acid, 4-Hydroxy-2-Oxohexanoic Acid, and 2-Hydroxyhexa-2,4-Dienoic Acid and Related Enzymes Involved in Testosterone Degradation in Comamonas testosteroni TA441. Appl Environ Microbiol. 2005 Sep;71(9):5275–81. doi: 10.1128/aem.71.9.5275-5281.2005.; Richmond W. Preparation and Properties of a Cholesterol Oxidase from Nocardia sp. and Its Application to the Enzymatic Assay of Total Cholesterol in Serum. 1973 Dec 01;19(12):1350–6. doi: 10.1093/clinchem/19.12.1350.; Stadtman TC, Cherkes A, Anfinsen CB. STUDIES ON THE MICROBIOLOGICAL DEGRADATION OF CHOLESTEROL. Journal of Biological Chemistry. 1954 Feb;206(2):511–23. doi: 10.1016/s0021-9258(19)50819-5. |
| androstenedione degradation Accession ID: BioCyc:MTBH37RV_PWY-6944 |
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| androstenedione degradation Accession ID: BioCyc:MTBCDC1551_PWY-6944 |
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