Pathways Knowlegdes
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| Pathway | DOIs | Note |
|---|---|---|
| ubiquinone-6 biosynthesis (eukaryotic) Accession ID: BioCyc:PCHR_PWY3O-19 |
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| ubiquinone (coenzyme Q) biosynthesis Accession ID: BioCyc:CALBI_PWY3B3-10 |
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| superpathway of ubiquinol-6 biosynthesis (eukaryotic) Accession ID: BioCyc:META_PWY-7235 |
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Xie LX, Ozeir M, Tang JY, Chen JY, Jaquinod S, Fontecave M, Clarke CF, Pierrel F. Overexpression of the Coq8 Kinase in Saccharomyces cerevisiae coq Null Mutants Allows for Accumulation of Diagnostic Intermediates of the Coenzyme Q6 Biosynthetic Pathway. Journal of Biological Chemistry. 2012 Jul;287(28):23571–81. doi: 10.1074/jbc.m112.360354.; Ozeir M, Mühlenhoff U, Webert H, Lill R, Fontecave M, Pierrel F. Coenzyme Q biosynthesis: Coq6 is required for the C5-hydroxylation reaction and substrate analogs rescue Coq6 deficiency. Chem Biol. 2011 Sep 23;18(9):1134–42. doi: 10.1016/j.chembiol.2011.07.008. PMID: 21944752.; Marbois B, Xie LX, Choi S, Hirano K, Hyman K, Clarke CF. para-Aminobenzoic Acid Is a Precursor in Coenzyme Q6 Biosynthesis in Saccharomyces cerevisiae. Journal of Biological Chemistry. 2010 Sep;285(36):27827–38. doi: 10.1074/jbc.m110.151894.; Pierrel F, Hamelin O, Douki T, Kieffer-Jaquinod S, Mühlenhoff U, Ozeir M, Lill R, Fontecave M. Involvement of mitochondrial ferredoxin and para-aminobenzoic acid in yeast coenzyme Q biosynthesis. Chem Biol. 2010 May 28;17(5):449–59. doi: 10.1016/j.chembiol.2010.03.014. PMID: 20534343.; Tauche A, Krause-Buchholz U, Rödel G. Ubiquinone biosynthesis in Saccharomyces cerevisiae: the molecular organization of O-methylase Coq3p depends on Abc1p/Coq8p. FEMS Yeast Res. 2008 Dec;8(8):1263–75. doi: 10.1111/j.1567-1364.2008.00436.x. PMID: 18801050.; Tran UC, Clarke CF. Endogenous synthesis of coenzyme Q in eukaryotes. Mitochondrion. 2007 Jun;7():S62–71. doi: 10.1016/j.mito.2007.03.007.; Barros MH, Nobrega FG. YAH1 of Saccharomyces cerevisiae: a new essential gene that codes for a protein homologous to human adrenodoxin. Gene. 1999 Jun 11;233(1-2):197–203. doi: 10.1016/s0378-1119(99)00137-7. PMID: 10375636.; Manzella L, Barros MH, Nobrega FG. ARH1 of Saccharomyces cerevisiae: a new essential gene that codes for a protein homologous to the human adrenodoxin reductase. Yeast. 1998 Jun 30;14(9):839–46. doi: 10.1002/(sici)1097-0061(19980630)14:9<839::aid-yea283>3.0.co;2-a. PMID: 9818721. |
| ubiquinol-6 biosynthesis from 4-hydroxybenzoate (eukaryotic) Accession ID: BioCyc:META_PWY3O-19 |
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Ozeir M, Mühlenhoff U, Webert H, Lill R, Fontecave M, Pierrel F. Coenzyme Q biosynthesis: Coq6 is required for the C5-hydroxylation reaction and substrate analogs rescue Coq6 deficiency. Chem Biol. 2011 Sep 23;18(9):1134–42. doi: 10.1016/j.chembiol.2011.07.008. PMID: 21944752.; Marbois B, Xie LX, Choi S, Hirano K, Hyman K, Clarke CF. para-Aminobenzoic Acid Is a Precursor in Coenzyme Q6 Biosynthesis in Saccharomyces cerevisiae. Journal of Biological Chemistry. 2010 Sep;285(36):27827–38. doi: 10.1074/jbc.m110.151894.; Pierrel F, Hamelin O, Douki T, Kieffer-Jaquinod S, Mühlenhoff U, Ozeir M, Lill R, Fontecave M. Involvement of mitochondrial ferredoxin and para-aminobenzoic acid in yeast coenzyme Q biosynthesis. Chem Biol. 2010 May 28;17(5):449–59. doi: 10.1016/j.chembiol.2010.03.014. PMID: 20534343.; Tran UC, Clarke CF. Endogenous synthesis of coenzyme Q in eukaryotes. Mitochondrion. 2007 Jun;7():S62–71. doi: 10.1016/j.mito.2007.03.007. |
| ubiquinol-6 bypass biosynthesis (eukaryotic) Accession ID: BioCyc:META_PWY-7233 |
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Xie LX, Ozeir M, Tang JY, Chen JY, Jaquinod S, Fontecave M, Clarke CF, Pierrel F. Overexpression of the Coq8 Kinase in Saccharomyces cerevisiae coq Null Mutants Allows for Accumulation of Diagnostic Intermediates of the Coenzyme Q6 Biosynthetic Pathway. Journal of Biological Chemistry. 2012 Jul;287(28):23571–81. doi: 10.1074/jbc.m112.360354.; Ozeir M, Mühlenhoff U, Webert H, Lill R, Fontecave M, Pierrel F. Coenzyme Q biosynthesis: Coq6 is required for the C5-hydroxylation reaction and substrate analogs rescue Coq6 deficiency. Chem Biol. 2011 Sep 23;18(9):1134–42. doi: 10.1016/j.chembiol.2011.07.008. PMID: 21944752.; Pierrel F, Hamelin O, Douki T, Kieffer-Jaquinod S, Mühlenhoff U, Ozeir M, Lill R, Fontecave M. Involvement of mitochondrial ferredoxin and para-aminobenzoic acid in yeast coenzyme Q biosynthesis. Chem Biol. 2010 May 28;17(5):449–59. doi: 10.1016/j.chembiol.2010.03.014. PMID: 20534343.; Tauche A, Krause-Buchholz U, Rödel G. Ubiquinone biosynthesis in Saccharomyces cerevisiae: the molecular organization of O-methylase Coq3p depends on Abc1p/Coq8p. FEMS Yeast Res. 2008 Dec;8(8):1263–75. doi: 10.1111/j.1567-1364.2008.00436.x. PMID: 18801050.; Padilla S, Tran UC, Jiménez-Hidalgo M, López-Martín JM, Martín-Montalvo A, Clarke CF, Navas P, Santos-Ocaña C. Hydroxylation of demethoxy-Q6 constitutes a control point in yeast coenzyme Q6 biosynthesis. Cellular and Molecular Life Sciences. 2008 Nov 11;66(1):173. doi: 10.1007/s00018-008-8547-7.; Tran UC, Clarke CF. Endogenous synthesis of coenzyme Q in eukaryotes. Mitochondrion. 2007 Jun;7():S62–71. doi: 10.1016/j.mito.2007.03.007. |
| ubiquinol-6 bypass biosynthesis Accession ID: BioCyc:YEAST_PWY-7233 |
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Xie LX, Ozeir M, Tang JY, Chen JY, Jaquinod S, Fontecave M, Clarke CF, Pierrel F. Overexpression of the Coq8 Kinase in Saccharomyces cerevisiae coq Null Mutants Allows for Accumulation of Diagnostic Intermediates of the Coenzyme Q6 Biosynthetic Pathway. Journal of Biological Chemistry. 2012 Jul;287(28):23571–81. doi: 10.1074/jbc.m112.360354.; Ozeir M, Mühlenhoff U, Webert H, Lill R, Fontecave M, Pierrel F. Coenzyme Q biosynthesis: Coq6 is required for the C5-hydroxylation reaction and substrate analogs rescue Coq6 deficiency. Chem Biol. 2011 Sep 23;18(9):1134–42. doi: 10.1016/j.chembiol.2011.07.008. PMID: 21944752.; Pierrel F, Hamelin O, Douki T, Kieffer-Jaquinod S, Mühlenhoff U, Ozeir M, Lill R, Fontecave M. Involvement of mitochondrial ferredoxin and para-aminobenzoic acid in yeast coenzyme Q biosynthesis. Chem Biol. 2010 May 28;17(5):449–59. doi: 10.1016/j.chembiol.2010.03.014. PMID: 20534343.; Tauche A, Krause-Buchholz U, Rödel G. Ubiquinone biosynthesis in Saccharomyces cerevisiae: the molecular organization of O-methylase Coq3p depends on Abc1p/Coq8p. FEMS Yeast Res. 2008 Dec;8(8):1263–75. doi: 10.1111/j.1567-1364.2008.00436.x. PMID: 18801050.; Padilla S, Tran UC, Jiménez-Hidalgo M, López-Martín JM, Martín-Montalvo A, Clarke CF, Navas P, Santos-Ocaña C. Hydroxylation of demethoxy-Q6 constitutes a control point in yeast coenzyme Q6 biosynthesis. Cellular and Molecular Life Sciences. 2008 Nov 11;66(1):173. doi: 10.1007/s00018-008-8547-7.; BOSTANCI HS, ARPAK MN. Long-term Evaluation of Surgical Periodontal Treatment with and without Maintenance Care. The Journal of Nihon University School of Dentistry. 1991;33(3):152–9. doi: 10.2334/josnusd1959.33.152. |
| ubiquinol-6 biosynthesis (eukaryotic) Accession ID: BioCyc:MOUSE_PWY3O-19 |
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| ubiquinol-6 biosynthesis (eukaryotic) Accession ID: BioCyc:THAPS_PWY3O-19 |
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| Ubiquinone Biosynthesis Accession ID: PathBank:SMP0000065 |
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| Ubiquinone Biosynthesis Accession ID: PathBank:SMP0087310 |
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| Ubiquinone Biosynthesis Accession ID: PathBank:SMP0063685 |
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| Ubiquinone Biosynthesis Accession ID: PathBank:SMP0002372 |
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| Ubiquinone Biosynthesis Accession ID: PathBank:SMP0087215 |
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| Ubiquinone Biosynthesis Accession ID: PathBank:SMP0087388 |
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| Ubiquinone Biosynthesis Accession ID: PathBank:SMP0087443 |
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