superpathway of purine nucleosides salvage

Rolfes RJ. Regulation of purine nucleotide biosynthesis: in yeast and beyond. Biochem Soc Trans. 2006 Nov;34(Pt 5):786–90. doi: 10.1042/bst0340786. PMID: 17052198.; Saint-Marc C, Daignan-Fornier B. GUD1 (YDL238c) encodes Saccharomyces cerevisiae guanine deaminase, an enzyme expressed during post-diauxic growth. Yeast. 2004 Nov 24;21(16):1359–63. doi: 10.1002/yea.1186.; Lecoq K, Belloc I, Desgranges C, Daignan-Fornier B. Role of adenosine kinase in Saccharomyces cerevisiae: identification of the ADO1 gene and study of the mutant phenotypes. Yeast. 2001 Mar 15;18(4):335–42. doi: 10.1002/1097-0061(20010315)18:4<335::aid-yea674>3.0.co;2-x. PMID: 11223943.; Deeley MC. Adenine deaminase and adenine utilization in Saccharomyces cerevisiae. J Bacteriol. 1992 May;174(10):3102–10. doi: 10.1128/jb.174.10.3102-3110.1992.

Metabolites

Adenine

Formula: C5H5N5 (135.054493)

CAS ID: 73-24-5

Adenosine

Formula: C10H13N5O4 (267.09674980000005)

CAS ID: 58-61-7

Diphosphate

Formula: H4P2O7 (177.9432294)

CAS ID: 2466-09-3

Guanine

Formula: C5H5N5O (151.049408)

CAS ID: 73-40-5

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

H2O

Formula: H2O (18.0105642)

CAS ID: 7732-18-5

Hypoxanthine

Formula: C5H4N4O (136.03850939999998)

CAS ID: 68-94-0

Inosine

Formula: C10H12N4O5 (268.08076619999997)

CAS ID: 58-63-9

Magnesium cation

Formula: Mg (23.98505)

CAS ID: 22537-22-0

Xanthine

Formula: C5H4N4O2 (152.0334244)

CAS ID: 69-89-6

adenosine 5'-monophosphate(2-)

Formula: C10H12N5O7P (345.0474332)

CAS ID:

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:



Enzyme

EC Number name full name note
2.4.2.-
2.4.2.1 purine-nucleoside phosphorylase purine-nucleoside:phosphate ribosyltransferase
2.4.2.7 adenine phosphoribosyltransferase AMP:diphosphate phospho-D-ribosyltransferase
2.4.2.8 hypoxanthine phosphoribosyltransferase IMP:diphosphate phospho-D-ribosyltransferase
2.7.1.20 adenosine kinase ATP:adenosine 5'-phosphotransferase
3.5.4.2 adenine deaminase adenine aminohydrolase
3.5.4.3 guanine deaminase guanine aminohydrolase
3.5.4.6 AMP deaminase AMP aminohydrolase


Proteins

Protein ID name full name
P15274 AMD1 AMP deaminase
P36973 APT2 Adenine phosphoribosyltransferase 2
P47143 ADO1 Adenosine kinase
P47165 XPT1 Xanthine phosphoribosyltransferase 1
P49435 APT1 Adenine phosphoribosyltransferase 1
P53909 AAH1 Adenine deaminase
Q04178 HPT1 Hypoxanthine-guanine phosphoribosyltransferase
Q05788 PNP1 Purine nucleoside phosphorylase
Q07729 GUD1 Probable guanine deaminase