tetrahydrofolate biosynthesis

Metabolites

Barium cation

Formula: Ba (137.905236)

CAS ID: 22541-12-4

Calcium cation

Formula: Ca (39.962591)

CAS ID: 14127-61-8

Diphosphate

Formula: H4P2O7 (177.9432294)

CAS ID: 2466-09-3

H+

Formula: H (1.0078246)

CAS ID: 12408-02-5

Magnesium cation

Formula: Mg (23.98505)

CAS ID: 22537-22-0

Potassium cation

Formula: K (38.963708)

CAS ID: 24203-36-9

Rubidium cation

Formula: Rb (84.9118)

CAS ID: 22537-38-8

Sodium cation

Formula: Na (22.98977)

CAS ID: 17341-25-2

Trimethoprim

Formula: C14H18N4O3 (290.1378838)

CAS ID: 738-70-5

4-aminobenzoate

Formula: C7H6NO2 (136.0398516)

CAS ID: 2906-28-7

6-hydroxymethyl-dihydropterin diphosphate

Formula: C7H8N5O8P2 (351.9848128)

CAS ID:

NADPH(4-)

Formula: C21H26N7O17P3 (741.0598016)

CAS ID: 53-57-6

ATP(4-)

Formula: C10H12N5O13P3 (502.9644492)

CAS ID:

ADP(3-)

Formula: C10H12N5O10P2 (424.0059412)

CAS ID:

NADP(3-)

Formula: C21H25N7O17P3 (740.051977)

CAS ID: 53-59-8



Enzyme

EC Number name full name note
1.5.1.3 dihydrofolate reductase 5,6,7,8-tetrahydrofolate:NADP+ oxidoreductase
1.5.1.50 dihydromonapterin reductase 5,6,7,8-tetrahydromonapterin:NADP+ oxidoreductase
2.5.1.15 dihydropteroate synthase (7,8-dihydropterin-6-yl)methyl diphosphate:4-aminobenzoate 2-amino-4-hydroxy-7,8-dihydropteridine-6-methenyltransferase
6.3.2.12 dihydrofolate synthase 7,8-dihydropteroate:L-glutamate ligase (ADP-forming)
6.3.2.17 tetrahydrofolate synthase tetrahydropteroyl-gamma-polyglutamate:L-glutamate gamma-ligase (ADP-forming)


Proteins

Protein ID name full name
P08192 folC Dihydrofolate synthase/folylpolyglutamate synthase
P0ABQ4 folA Dihydrofolate reductase
P0AC13 folP Dihydropteroate synthase
P0AFS3 folM Dihydromonapterin reductase